|
|
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char = c;code = 99
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char = r;code = 114
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result sql = Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers.
Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers.char = T;code = 84
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char = r;code = 114
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char = s;code = 115
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char = b;code = 98
char = l;code = 108
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result sql = This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.
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char = b;code = 98
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char = r;code = 114
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result sql = Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers.
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result sql = This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.
Publication: Bioorg. Med. Chem. Lett. 2006 Oct 1 ;16(19)::5014-7.
Publication Date: 2006 Oct 1
Study Author(s): Lee, Jae Yeol;Park, Seong Jun;Park, Sung Jun;Lee, Min Joo;Rhim, Hyewhon;Seo, Seon Hee;Kim, Ki-Sun;
Institution: Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Seoul 130-701, Republic of Korea. [email protected]
Shortcut link to this study:
Publication Date: 2006 Oct 1
Study Author(s): Lee, Jae Yeol;Park, Seong Jun;Park, Sung Jun;Lee, Min Joo;Rhim, Hyewhon;Seo, Seon Hee;Kim, Ki-Sun;
Institution: Research Institute for Basic Sciences and Department of Chemistry, College of Sciences, Kyung Hee University, 1 Hoegi-Dong, Seoul 130-701, Republic of Korea. [email protected]
Shortcut link to this study:
This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.
PMID: 16876410
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