char = C;code = 67
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = o;code = 111
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char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = t;code = 116
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char = e;code = 101
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
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char = o;code = 111
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = w;code = 119
char = n;code = 110
char = -;code = 45
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = n;code = 110
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = -;code = 45
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
char = B;code = 66
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = u;code = 117
char = c;code = 99
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char = e;code = 101
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = -;code = 45
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
char = B;code = 66
char = -;code = 45
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = I;code = 73
char = F;code = 70
char = N;code = 78
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = -;code = 45
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = I;code = 73
char = F;code = 70
char = N;code = 78
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = -;code = 45
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = l;code = 108
char = a;code = 97
char = d;code = 100
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.

Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.

char = B;code = 66
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char = c;code = 99
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char = n;code = 110
char = c;code = 99
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char = e;code = 101
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char = b;code = 98
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char = g;code = 103
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char = i;code = 105
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char = W;code = 87
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char = t;code = 116
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char = E;code = 69
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char = ;code = 32
char = c;code = 99
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char = s;code = 115
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char = h;code = 104
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char = I;code = 73
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char = ;code = 32
char = C;code = 67
char = i;code = 105
char = g;code = 103
char = a;code = 97
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char = e;code = 101
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char = t;code = 116
char = e;code = 101
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char = o;code = 111
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char = n;code = 110
char = g;code = 103
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char = i;code = 105
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char = b;code = 98
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char = d;code = 100
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char = f;code = 102
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char = ;code = 32
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char = U;code = 85
char = n;code = 110
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char = d;code = 100
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char = a;code = 97
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char = m;code = 109
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char = i;code = 105
char = c;code = 99
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char = c;code = 99
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char = c;code = 99
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char = e;code = 101
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char = t;code = 116
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char = ;code = 32
char = c;code = 99
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char = c;code = 99
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char = W;code = 87
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char = c;code = 99
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char = I;code = 73
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char = i;code = 105
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char = ;code = 32
char = D;code = 68
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char = i;code = 105
char = n;code = 110
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char = b;code = 98
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char = I;code = 73
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char = a;code = 97
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char = p;code = 112
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char = i;code = 105
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char = 4;code = 52
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char = 6;code = 54
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char = a;code = 97
char = l;code = 108
char = p;code = 112
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char = 7;code = 55
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char = e;code = 101
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char = l;code = 108
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char = C;code = 67
char = u;code = 117
char = r;code = 114
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char = u;code = 117
char = m;code = 109
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char = a;code = 97
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char = o;code = 111
char = p;code = 112
char = t;code = 116
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char = f;code = 102
char = e;code = 101
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char = e;code = 101
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char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
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char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
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char = e;code = 101
char = n;code = 110
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char = s;code = 115
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char = c;code = 99
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char = b;code = 98
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char = e;code = 101
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char = a;code = 97
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char = p;code = 112
char = a;code = 97
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char = t;code = 116
char = a;code = 97
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char = f;code = 102
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char = c;code = 99
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char = [;code = 91
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char = m;code = 109
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char = r;code = 114
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char = c;code = 99
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char = o;code = 111
char = s;code = 115
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char = s;code = 115
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
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char = (;code = 40
char = T;code = 84
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char = F;code = 70
char = );code = 41
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = T;code = 84
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = r;code = 114
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char = l;code = 108
char = a;code = 97
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char = o;code = 111
char = p;code = 112
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char = a;code = 97
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char = i;code = 105
char = s;code = 115
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char = f;code = 102
char = e;code = 101
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char = i;code = 105
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char = F;code = 70
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char = W;code = 87
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char = p;code = 112
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char = N;code = 78
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char = k;code = 107
char = a;code = 97
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char = a;code = 97
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char = n;code = 110
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char = o;code = 111
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result sql = Bladder cancer mortality varies between the countries; whereas being highest in Western countries, it is lowest in Eastern countries, such as India. Cigarette smoking is one of the major risk factors for bladder cancer in affluent nations, such as United States. Localized early-stage bladder cancer is treated with resection and intravesical cytokine therapy, whereas metastatic cancer is typically treated with various combinations of systemic chemotherapy. Whether curcumin, a yellow curry pigment commonly consumed in countries, such as India, has any role in prevention or treatment of bladder cancer was investigated. We found that curcumin inhibited the proliferation, induced cell cycle arrest, and DNA fragmentation in both IFN-alpha-sensitive (RT4V6) and IFN-alpha-resistant (KU-7) bladder cancer cells. Curcumin also potentiated the apoptotic effects of the chemotherapeutic agents (gemcitabine and paclitaxel) and of cytokines [tumor necrosis factor (TNF) and TNF-related apoptosis-inducing ligand]. This effect of curcumin was independent of sensitivity and resistance to IFN-alpha, commonly used for treatment of bladder cancer. Whether the effects of curcumin are mediated through modulation of the nuclear factor-kappaB (NF-kappaB) pathway known to mediate antiapoptosis was investigated. Both gemcitabine and TNF activated NF-kappaB in bladder cancer cells and curcumin suppressed this activation. Similarly, cigarette smoke, a major risk factor for bladder cancer, also activated NF-kappaB and curcumin suppressed it. Cigarette smoke-induced expression of the NF-kappaB-regulated gene products cyclooxygenase-2 and vascular endothelial growth factor, linked with proliferation and angiogenesis, respectively, was also down-regulated by curcumin.

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