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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = S;code = 83
char = T;code = 84
char = A;code = 65
char = T;code = 84
char = 3;code = 51
char = .;code = 46
result sql = Physiologically achievable concentrations of genistein enhance telomerase activity in prostate cancer cells via the activation of STAT3.
Physiologically achievable concentrations of genistein enhance telomerase activity in prostate cancer cells via the activation of STAT3.
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char = r;code = 114
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char = h;code = 104
char = e;code = 101
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char = i;code = 105
char = v;code = 118
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = S;code = 83
char = T;code = 84
char = A;code = 65
char = T;code = 84
char = 3;code = 51
char = .;code = 46
char = ;code = 32
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char = o;code = 111
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char = l;code = 108
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char = e;code = 101
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char = c;code = 99
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char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = n;code = 110
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char = s;code = 115
char = t;code = 116
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
char = l;code = 108
char = l;code = 108
char = ;code = 32
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char = g;code = 103
char = m;code = 109
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char = t;code = 116
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char = ;code = 32
char = g;code = 103
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char = ;code = 32
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char = d;code = 100
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char = ;code = 32
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char = m;code = 109
char = e;code = 101
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char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = t;code = 116
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char = ;code = 32
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char = i;code = 105
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char = a;code = 97
char = l;code = 108
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
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char = r;code = 114
char = o;code = 111
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char = t;code = 116
char = a;code = 97
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char = ;code = 32
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char = e;code = 101
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char = a;code = 97
char = u;code = 117
char = t;code = 116
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char = o;code = 111
char = n;code = 110
char = ;code = 32
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char = h;code = 104
char = o;code = 111
char = u;code = 117
char = l;code = 108
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char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
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char = e;code = 101
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char = c;code = 99
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char = s;code = 115
char = e;code = 101
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char = h;code = 104
char = e;code = 101
char = n;code = 110
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char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = p;code = 112
char = u;code = 117
char = r;code = 114
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = /;code = 47
char = >;code = 62
result sql = Telomerase contributes to the infinite replicative potential of cancer cells by conferring proliferation and survival through the regulation of growth factors and apoptotic proteins. Although it is generally known that the phytoestrogen, genistein, has telomerase-repressing and anti-proliferative effects on various cancer cells at pharmacological concentrations, we report here that physiologically achievable concentrations of genistein enhance telomerase activity, the proliferation of human prostate cancer cells and tumor growth in the transgenic adenocarcinoma mouse prostate model. In determining the mechanism for enhanced telomerase activity, we observed that physiological concentrations of genistein activated signal transducers and activators of transcription 3 (STAT3) both in vitro and in vivo and increased STAT3 binding to the telomerase reverse transcriptase promoter in human prostate cancer cells. These results demonstrate for the first time that physiologically achievable concentrations of genistein enhance telomerase reverse transcriptase transcriptional activity in prostate cancer cells via the activation of STAT3. Consequently, these concentrations of genistein will augment the growth of prostate cancer cells that could be detrimental to individuals with prostate cancer and therefore, caution should be exercised when genistein is considered for chemotherapeutic purposes.

Publication: Carcinogenesis 2007 Nov ;28(11)::2282-90.
Publication Date: 2007 Nov
Study Author(s): Chau, My N;El Touny, Lara H;Jagadeesh, Shankar;Banerjee, Partha P;
Institution: Department of Biochemistry and Molecular and Cellular Biology, Medical-Dental Building, Georgetown University Medical Center, 3900 Reservoir Road, NW, Washington, DC 20057, USA.
Shortcut link to this study:
Telomerase contributes to the infinite replicative potential of cancer cells by conferring proliferation and survival through the regulation of growth factors and apoptotic proteins. Although it is generally known that the phytoestrogen, genistein, has telomerase-repressing and anti-proliferative effects on various cancer cells at pharmacological concentrations, we report here that physiologically achievable concentrations of genistein enhance telomerase activity, the proliferation of human prostate cancer cells and tumor growth in the transgenic adenocarcinoma mouse prostate model. In determining the mechanism for enhanced telomerase activity, we observed that physiological concentrations of genistein activated signal transducers and activators of transcription 3 (STAT3) both in vitro and in vivo and increased STAT3 binding to the telomerase reverse transcriptase promoter in human prostate cancer cells. These results demonstrate for the first time that physiologically achievable concentrations of genistein enhance telomerase reverse transcriptase transcriptional activity in prostate cancer cells via the activation of STAT3. Consequently, these concentrations of genistein will augment the growth of prostate cancer cells that could be detrimental to individuals with prostate cancer and therefore, caution should be exercised when genistein is considered for chemotherapeutic purposes.
PMID: 17615260

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