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char = o;code = 111
char = p;code = 112
char = ?;code = 63
result sql = Calcium-sensing receptor in cancer: good cop or bad cop?
Calcium-sensing receptor in cancer: good cop or bad cop?
char = T;code = 84
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char = l;code = 108
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char = i;code = 105
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char = e;code = 101
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char = a;code = 97
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char = c;code = 99
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char = c;code = 99
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char = g;code = 103
char = h;code = 104
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char = m;code = 109
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char = i;code = 105
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char = o;code = 111
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char = ;code = 32
char = C;code = 67
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char = R;code = 82
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char = s;code = 115
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char = c;code = 99
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char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = a;code = 97
char = R;code = 82
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = i;code = 105
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char = a;code = 97
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char = ;code = 32
char = i;code = 105
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char = m;code = 109
char = a;code = 97
char = l;code = 108
char = i;code = 105
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char = n;code = 110
char = a;code = 97
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char = s;code = 115
char = i;code = 105
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char = .;code = 46
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char = O;code = 79
char = n;code = 110
char = e;code = 101
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char = u;code = 117
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char = s;code = 115
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char = g;code = 103
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char = ;code = 32
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char = l;code = 108
char = o;code = 111
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char = n;code = 110
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char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
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char = c;code = 99
char = e;code = 101
char = p;code = 112
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char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
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char = i;code = 105
char = r;code = 114
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = b;code = 98
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char = s;code = 115
char = t;code = 116
char = -;code = 45
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char = t;code = 116
char = e;code = 101
char = ;code = 32
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char = o;code = 111
char = r;code = 114
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result sql = The extracellular calcium-sensing receptor (CaR) is a versatile 'sensor' for di- and polycationic molecules in the body. CaR plays a key role in the defense against hypercalcemia by "sensing" extracellular calcium levels in the parathyroid and kidney, the key organs maintaining systemic calcium homeostasis. Although mutation of CaR gene has so far not been associated with any malignancy, aberrant functions of CaR have implications in malignant progression. One situation is loss of CaR expression, resulting in loss of growth suppressing effects of elevated extracellular Ca(2+) by CaR, reported in parathyroid adenoma and in colon carcinoma. Another situation is activation of CaR, resulting in increased production of parathyroid hormone-related peptide (PTHrP), a primary causal factor in hypercalcemia of malignancy and a contributor to metastatic processes involving bone. CaR signaling and effects have been studied in several cancers including ovarian cancers, gastrinomas, and gliomas in addition to comparatively detailed studies in breast, prostate, and colon cancers. Studies on H-500 rat Leydig cells, a xenotransplantable model of humoral hypercalcemia of malignancy has shed much light on the mechanisms of CaR-induced cancer cell growth and survival. Pharmacological agonists and antagonists of CaR hold therapeutic promise depending on whether activation of CaR is required such as in case of colon cancer or inactivating the receptor is required as in the case of breast- and prostate tumors.

Publication: Endocrine 2009 Jun ;35(3)::271-84. :doi: 10.1007/s12020-008-9131-5.
Publication Date: 2009 Jun
Study Author(s): Chakravarti, Bandana;Dwivedi, Shailendra Kumar Dhar;Mithal, Ambrish;Chattopadhyay, Naibedya;
Institution: Division of Endocrinology, Central Drug Research Institute, Chattar Manzil, Lucknow, India. [email protected]
Shortcut link to this study:
The extracellular calcium-sensing receptor (CaR) is a versatile 'sensor' for di- and polycationic molecules in the body. CaR plays a key role in the defense against hypercalcemia by "sensing" extracellular calcium levels in the parathyroid and kidney, the key organs maintaining systemic calcium homeostasis. Although mutation of CaR gene has so far not been associated with any malignancy, aberrant functions of CaR have implications in malignant progression. One situation is loss of CaR expression, resulting in loss of growth suppressing effects of elevated extracellular Ca(2+) by CaR, reported in parathyroid adenoma and in colon carcinoma. Another situation is activation of CaR, resulting in increased production of parathyroid hormone-related peptide (PTHrP), a primary causal factor in hypercalcemia of malignancy and a contributor to metastatic processes involving bone. CaR signaling and effects have been studied in several cancers including ovarian cancers, gastrinomas, and gliomas in addition to comparatively detailed studies in breast, prostate, and colon cancers. Studies on H-500 rat Leydig cells, a xenotransplantable model of humoral hypercalcemia of malignancy has shed much light on the mechanisms of CaR-induced cancer cell growth and survival. Pharmacological agonists and antagonists of CaR hold therapeutic promise depending on whether activation of CaR is required such as in case of colon cancer or inactivating the receptor is required as in the case of breast- and prostate tumors.
PMID: 19011996

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