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|
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result sql = Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry.
Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry.char = A;code = 65
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char = ;code = 32
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char = o;code = 111
char = m;code = 109
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
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char = s;code = 115
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char = m;code = 109
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char = n;code = 110
char = ;code = 32
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char = r;code = 114
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char = >;code = 62
result sql = Accumulating data point to K(+) channels as relevant players in controlling cell cycle progression and proliferation of human cancer cells, including prostate cancer (PCa) cells. However, the mechanism(s) by which K(+) channels control PCa cell proliferation remain illusive. In this study, using the techniques of molecular biology, biochemistry, electrophysiology and calcium imaging, we studied the expression and functionality of intermediate-conductance calcium-activated potassium channels (IK(Ca1)) in human PCa as well as their involvement in cell proliferation. We showed that IK(Ca1) mRNA and protein were preferentially expressed in human PCa tissues, and inhibition of the IK(Ca1) potassium channel suppressed PCa cell proliferation. The activation of IK(Ca1) hyperpolarizes membrane potential and, by promoting the driving force for calcium, induces calcium entry through TRPV6, a cation channel of the TRP (Transient Receptor Potential) family. Thus, the overexpression of the IK(Ca1) channel is likely to promote carcinogenesis in human prostate tissue.
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char = t;code = 116
char = e;code = 101
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char = d;code = 100
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char = n;code = 110
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char = i;code = 105
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char = o;code = 111
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char = ;code = 32
char = c;code = 99
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char = o;code = 111
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char = e;code = 101
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result sql = Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry.
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result sql = Accumulating data point to K(+) channels as relevant players in controlling cell cycle progression and proliferation of human cancer cells, including prostate cancer (PCa) cells. However, the mechanism(s) by which K(+) channels control PCa cell proliferation remain illusive. In this study, using the techniques of molecular biology, biochemistry, electrophysiology and calcium imaging, we studied the expression and functionality of intermediate-conductance calcium-activated potassium channels (IK(Ca1)) in human PCa as well as their involvement in cell proliferation. We showed that IK(Ca1) mRNA and protein were preferentially expressed in human PCa tissues, and inhibition of the IK(Ca1) potassium channel suppressed PCa cell proliferation. The activation of IK(Ca1) hyperpolarizes membrane potential and, by promoting the driving force for calcium, induces calcium entry through TRPV6, a cation channel of the TRP (Transient Receptor Potential) family. Thus, the overexpression of the IK(Ca1) channel is likely to promote carcinogenesis in human prostate tissue.
Publication: Oncogene 2009 Apr 16 ;28(15)::1792-806. :doi: 10.1038/onc.2009.25.
Publication Date: 2009 Apr 16
Study Author(s): Lallet-Daher, H;Roudbaraki, M;Bavencoffe, A;Mariot, P;Gackière, F;Bidaux, G;Urbain, R;Gosset, P;Delcourt, P;Fleurisse, L;Slomianny, C;Dewailly, E;Mauroy, B;Bonnal, J L;Skryma, R;Prevarskaya, N;
Institution: INSERM U800, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d'Ascq, France.
Shortcut link to this study:
Publication Date: 2009 Apr 16
Study Author(s): Lallet-Daher, H;Roudbaraki, M;Bavencoffe, A;Mariot, P;Gackière, F;Bidaux, G;Urbain, R;Gosset, P;Delcourt, P;Fleurisse, L;Slomianny, C;Dewailly, E;Mauroy, B;Bonnal, J L;Skryma, R;Prevarskaya, N;
Institution: INSERM U800, Equipe Labellisée par la Ligue Nationale Contre le Cancer, Villeneuve d'Ascq, France.
Shortcut link to this study:
Accumulating data point to K(+) channels as relevant players in controlling cell cycle progression and proliferation of human cancer cells, including prostate cancer (PCa) cells. However, the mechanism(s) by which K(+) channels control PCa cell proliferation remain illusive. In this study, using the techniques of molecular biology, biochemistry, electrophysiology and calcium imaging, we studied the expression and functionality of intermediate-conductance calcium-activated potassium channels (IK(Ca1)) in human PCa as well as their involvement in cell proliferation. We showed that IK(Ca1) mRNA and protein were preferentially expressed in human PCa tissues, and inhibition of the IK(Ca1) potassium channel suppressed PCa cell proliferation. The activation of IK(Ca1) hyperpolarizes membrane potential and, by promoting the driving force for calcium, induces calcium entry through TRPV6, a cation channel of the TRP (Transient Receptor Potential) family. Thus, the overexpression of the IK(Ca1) channel is likely to promote carcinogenesis in human prostate tissue.
PMID: 19270724
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