|
|
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result sql = Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol.
Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol.char = R;code = 82
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char = g;code = 103
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char = d;code = 100
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result sql = Resveratrol is a well-known natural antioxidant and cancer chemopreventive agent that has attracted much interest in the past decade. Resveratrol-directed compounds were synthesized, and their antioxidant effects against reactive oxygen species (ROS)-induced DNA damage, their prooxidant effects on DNA damage in the presence cupric ions, and their cytotoxic and apoptosis-inducing effects on human promyelocytic leukemia (HL-60) cells were investigated in vitro. It was found that the compounds bearing o-diphenoxyl groups exhibited remarkably higher activities in inhibiting ROS-induced DNA damage, accelerating DNA damage in the presence cupric ions, and inducing apoptosis of HL-60 cells compared with the ones bearing no such groups. The detail mechanism of the structure-activity relationship was also studied by the oxidative product analysis of resveratrol and its analogues with galvinoxyl radical or cupric ions and UV-visible spectra change in the presence cupric ions. This study reveals a good and interesting correlation between antioxidant and prooxidant activity, as well as cytotoxicity and apoptosis-inducing activity against HL-60 cells, and provides an idea for designing antioxidant-based cancer chemoprevention agents.
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char = r;code = 114
char = o;code = 111
char = l;code = 108
char = .;code = 46
result sql = Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol.
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char = c;code = 99
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char = a;code = 97
char = n;code = 110
char = d;code = 100
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char = -;code = 45
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char = s;code = 115
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char = b;code = 98
char = l;code = 108
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char = n;code = 110
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char = e;code = 101
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char = s;code = 115
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char = c;code = 99
char = e;code = 101
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char = c;code = 99
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char = p;code = 112
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char = c;code = 99
char = ;code = 32
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = T;code = 84
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = g;code = 103
char = o;code = 111
char = o;code = 111
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = e;code = 101
char = r;code = 114
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char = s;code = 115
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = r;code = 114
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char = e;code = 101
char = l;code = 108
char = a;code = 97
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char = i;code = 105
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char = e;code = 101
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char = n;code = 110
char = t;code = 116
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char = o;code = 111
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char = i;code = 105
char = d;code = 100
char = a;code = 97
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char = t;code = 116
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char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = i;code = 105
char = d;code = 100
char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = y;code = 121
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char = ;code = 32
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char = s;code = 115
char = ;code = 32
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char = l;code = 108
char = l;code = 108
char = ;code = 32
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char = s;code = 115
char = ;code = 32
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char = c;code = 99
char = i;code = 105
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char = t;code = 116
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char = L;code = 76
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char = 6;code = 54
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char = ;code = 32
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char = i;code = 105
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char = e;code = 101
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char = i;code = 105
char = d;code = 100
char = e;code = 101
char = a;code = 97
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = i;code = 105
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char = n;code = 110
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = d;code = 100
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = e;code = 101
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char = n;code = 110
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = /;code = 47
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result sql = Resveratrol is a well-known natural antioxidant and cancer chemopreventive agent that has attracted much interest in the past decade. Resveratrol-directed compounds were synthesized, and their antioxidant effects against reactive oxygen species (ROS)-induced DNA damage, their prooxidant effects on DNA damage in the presence cupric ions, and their cytotoxic and apoptosis-inducing effects on human promyelocytic leukemia (HL-60) cells were investigated in vitro. It was found that the compounds bearing o-diphenoxyl groups exhibited remarkably higher activities in inhibiting ROS-induced DNA damage, accelerating DNA damage in the presence cupric ions, and inducing apoptosis of HL-60 cells compared with the ones bearing no such groups. The detail mechanism of the structure-activity relationship was also studied by the oxidative product analysis of resveratrol and its analogues with galvinoxyl radical or cupric ions and UV-visible spectra change in the presence cupric ions. This study reveals a good and interesting correlation between antioxidant and prooxidant activity, as well as cytotoxicity and apoptosis-inducing activity against HL-60 cells, and provides an idea for designing antioxidant-based cancer chemoprevention agents.
Publication: J. Med. Chem. 2009 Apr 9 ;52(7)::1963-74. :doi: 10.1021/jm8015415.
Publication Date: 2009 Apr 9
Study Author(s): Qian, Yi-Ping;Cai, Yu-Jun;Fan, Gui-Juan;Wei, Qing-Yi;Yang, Jie;Zheng, Li-Fang;Li, Xiu-Zhuang;Fang, Jian-Guo;Zhou, Bo;
Institution: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, China.
Shortcut link to this study:
Publication Date: 2009 Apr 9
Study Author(s): Qian, Yi-Ping;Cai, Yu-Jun;Fan, Gui-Juan;Wei, Qing-Yi;Yang, Jie;Zheng, Li-Fang;Li, Xiu-Zhuang;Fang, Jian-Guo;Zhou, Bo;
Institution: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu, China.
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Resveratrol is a well-known natural antioxidant and cancer chemopreventive agent that has attracted much interest in the past decade. Resveratrol-directed compounds were synthesized, and their antioxidant effects against reactive oxygen species (ROS)-induced DNA damage, their prooxidant effects on DNA damage in the presence cupric ions, and their cytotoxic and apoptosis-inducing effects on human promyelocytic leukemia (HL-60) cells were investigated in vitro. It was found that the compounds bearing o-diphenoxyl groups exhibited remarkably higher activities in inhibiting ROS-induced DNA damage, accelerating DNA damage in the presence cupric ions, and inducing apoptosis of HL-60 cells compared with the ones bearing no such groups. The detail mechanism of the structure-activity relationship was also studied by the oxidative product analysis of resveratrol and its analogues with galvinoxyl radical or cupric ions and UV-visible spectra change in the presence cupric ions. This study reveals a good and interesting correlation between antioxidant and prooxidant activity, as well as cytotoxicity and apoptosis-inducing activity against HL-60 cells, and provides an idea for designing antioxidant-based cancer chemoprevention agents.
PMID: 19271734
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