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result sql = Dysregulated Th1 and Th2 responses in food-allergic children--does elimination diet contribute to the dysregulation?

Dysregulated Th1 and Th2 responses in food-allergic children--does elimination diet contribute to the dysregulation?

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char = e;code = 101
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char = c;code = 99
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char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
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char = n;code = 110
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = f;code = 102
char = i;code = 105
char = n;code = 110
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char = d;code = 100
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = e;code = 101
char = r;code = 114
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = e;code = 101
char = g;code = 103
char = g;code = 103
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = /;code = 47
char = o;code = 111
char = r;code = 114
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char = m;code = 109
char = i;code = 105
char = l;code = 108
char = k;code = 107
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char = b;code = 98
char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = p;code = 112
char = e;code = 101
char = n;code = 110
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char = o;code = 111
char = r;code = 114
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char = d;code = 100
char = o;code = 111
char = u;code = 117
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = -;code = 45
char = b;code = 98
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = p;code = 112
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char = a;code = 97
char = c;code = 99
char = e;code = 101
char = b;code = 98
char = o;code = 111
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
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char = l;code = 108
char = l;code = 108
char = e;code = 101
char = d;code = 100
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char = f;code = 102
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char = o;code = 111
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char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = e;code = 101
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = P;code = 80
char = e;code = 101
char = r;code = 114
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char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
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char = b;code = 98
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char = o;code = 111
char = o;code = 111
char = d;code = 100
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char = m;code = 109
char = o;code = 111
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = (;code = 40
char = P;code = 80
char = B;code = 66
char = M;code = 77
char = C;code = 67
char = );code = 41
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = l;code = 108
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = e;code = 101
char = n;code = 110
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char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = f;code = 102
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = 6;code = 54
char = ;code = 32
char = w;code = 119
char = k;code = 107
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = 3;code = 51
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = 4;code = 52
char = (;code = 40
char = 1;code = 49
char = /;code = 47
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = y;code = 121
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = O;code = 79
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = b;code = 98
char = u;code = 117
char = m;code = 109
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = l;code = 108
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = g;code = 103
char = l;code = 108
char = o;code = 111
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char = u;code = 117
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = n;code = 110
char = d;code = 100
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char = t;code = 116
char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = u;code = 117
char = s;code = 115
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char = t;code = 116
char = o;code = 111
char = x;code = 120
char = o;code = 111
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char = d;code = 100
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = I;code = 73
char = L;code = 76
char = -;code = 45
char = 4;code = 52
char = ,;code = 44
char = ;code = 32
char = -;code = 45
char = 5;code = 53
char = ,;code = 44
char = ;code = 32
char = -;code = 45
char = 1;code = 49
char = 0;code = 48
char = ,;code = 44
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char = -;code = 45
char = 1;code = 49
char = 3;code = 51
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = I;code = 73
char = F;code = 70
char = N;code = 78
char = -;code = 45
char = g;code = 103
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = d;code = 100
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char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = P;code = 80
char = B;code = 66
char = M;code = 77
char = C;code = 67
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = a;code = 97
char = l;code = 108
char = y;code = 121
char = z;code = 122
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char = d;code = 100
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = y;code = 121
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char = k;code = 107
char = e;code = 101
char = d;code = 100
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char = m;code = 109
char = m;code = 109
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char = n;code = 110
char = o;code = 111
char = s;code = 115
char = o;code = 111
char = r;code = 114
char = b;code = 98
char = e;code = 101
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char = t;code = 116
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = a;code = 97
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = I;code = 73
char = F;code = 70
char = N;code = 78
char = -;code = 45
char = g;code = 103
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = I;code = 73
char = L;code = 76
char = -;code = 45
char = 5;code = 53
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char = s;code = 115
char = e;code = 101
char = c;code = 99
char = r;code = 114
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char = i;code = 105
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char = u;code = 117
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char = e;code = 101
char = d;code = 100
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char = b;code = 98
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char = f;code = 102
char = o;code = 111
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char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = l;code = 108
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = a;code = 97
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char = ;code = 32
char = 4;code = 52
char = (;code = 40
char = 1;code = 49
char = /;code = 47
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = y;code = 121
char = r;code = 114
char = ;code = 32
char = w;code = 119
char = a;code = 97
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char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = c;code = 99
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char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = c;code = 99
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = e;code = 101
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char = w;code = 119
char = h;code = 104
char = o;code = 111
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = a;code = 97
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char = l;code = 108
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = i;code = 105
char = c;code = 99
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char = t;code = 116
char = o;code = 111
char = ;code = 32
char = e;code = 101
char = g;code = 103
char = g;code = 103
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char = o;code = 111
char = r;code = 114
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char = m;code = 109
char = i;code = 105
char = l;code = 108
char = k;code = 107
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = o;code = 111
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char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = t;code = 116
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char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = o;code = 111
char = d;code = 100
char = -;code = 45
char = a;code = 97
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char = l;code = 108
char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = c;code = 99
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char = i;code = 105
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char = r;code = 114
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char = e;code = 101
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char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = I;code = 73
char = F;code = 70
char = N;code = 78
char = -;code = 45
char = g;code = 103
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = I;code = 73
char = L;code = 76
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char = 5;code = 53
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char = w;code = 119
char = e;code = 101
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char = a;code = 97
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char = 1;code = 49
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char = e;code = 101
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char = t;code = 116
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char = e;code = 101
char = a;code = 97
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char = a;code = 97
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char = g;code = 103
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char = r;code = 114
char = a;code = 97
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char = l;code = 108
char = y;code = 121
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char = n;code = 110
char = o;code = 111
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char = ;code = 32
char = o;code = 111
char = b;code = 98
char = s;code = 115
char = e;code = 101
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char = e;code = 101
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char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = t;code = 116
char = o;code = 111
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char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = e;code = 101
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char = w;code = 119
char = h;code = 104
char = o;code = 111
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char = c;code = 99
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char = s;code = 115
char = u;code = 117
char = m;code = 109
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char = l;code = 108
char = k;code = 107
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = e;code = 101
char = g;code = 103
char = g;code = 103
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = m;code = 109
char = u;code = 117
char = n;code = 110
char = e;code = 101
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char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = s;code = 115
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char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = f;code = 102
char = o;code = 111
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char = -;code = 45
char = a;code = 97
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char = l;code = 108
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = i;code = 105
char = c;code = 99
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char = c;code = 99
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = e;code = 101
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char = o;code = 111
char = n;code = 110
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char = a;code = 97
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char = e;code = 101
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char = i;code = 105
char = m;code = 109
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = o;code = 111
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char = d;code = 100
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = u;code = 117
char = p;code = 112
char = -;code = 45
char = r;code = 114
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char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = T;code = 84
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = l;code = 108
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = 1;code = 49
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = T;code = 84
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = l;code = 108
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = 2;code = 50
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = o;code = 111
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = b;code = 98
char = a;code = 97
char = l;code = 108
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = m;code = 109
char = u;code = 117
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = n;code = 110
char = o;code = 111
char = c;code = 99
char = u;code = 117
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = o;code = 111
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Infants with eczema and sensitization to foods are recommended skin care and, if food allergy is proven, an elimination diet. Although most of these children tolerate foods before 3 yr of age, some children experience prolonged food allergy. To our knowledge, no prospective study has investigated the cytokine profile in food-sensitized eczematous children with prolonged food intolerance. The aim of the study was to prospectively investigate the development of cytokine production induced by food allergen in food-sensitized eczematous children who, at 4(1/2) yr of age, were allergic or tolerant to egg or milk. Twenty-one eczematous infants, [age 5 (3-10) months; median and range], sensitized to egg and/or milk were included, put on elimination diet and followed prospectively. At 4(1/2) yr of age, the children were defined as tolerant or allergic to egg and/or milk based on open or double-blind placebo-controlled food challenges. Peripheral blood mononuclear cells (PBMC) were isolated from the children on inclusion, after 6 wk of elimination diet, and at 3 and 4(1/2) yr of age. Ovalbumin, beta-lactoglobulin and tetanus toxoid-induced IL-4, -5, -10, -13 and IFN-gamma production from PBMC were analyzed with enzyme-linked immunosorbent assay. The IFN-gamma and IL-5 secretion induced by food allergen at 4(1/2) yr was higher in cell cultures from children who were allergic to egg or milk than in tolerant children. In food-allergic children, the levels of IFN-gamma and IL-5 were higher at 4(1/2) yr compared with inclusion levels, but this increase was generally not observed in the tolerant children who consumed milk and egg. In conclusion, immune cells from food-allergic children on an elimination diet respond with up-regulated T helper 1 and T helper 2 cytokine secretion induced by food allergen. We hypothesize that allergen elimination may influence the regulatory mechanisms maintaining balanced immune responses to innocuous food antigens.

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