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char = .;code = 46
result sql = Polymorphism of cytochrome p450, glutathione-s-transferase and N-acetyltransferases: influence on lung cancer susceptibility.
Polymorphism of cytochrome p450, glutathione-s-transferase and N-acetyltransferases: influence on lung cancer susceptibility.
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char = e;code = 101
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char = m;code = 109
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char = o;code = 111
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char = m;code = 109
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char = t;code = 116
char = ;code = 32
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char = e;code = 101
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char = s;code = 115
char = ;code = 32
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char = a;code = 97
char = t;code = 116
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char = b;code = 98
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char = b;code = 98
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char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = ;code = 32
char = o;code = 111
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char = g;code = 103
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char = n;code = 110
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char = t;code = 116
char = i;code = 105
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char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
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char = s;code = 115
char = e;code = 101
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char = ;code = 32
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char = i;code = 105
char = s;code = 115
char = ;code = 32
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char = v;code = 118
char = i;code = 105
char = e;code = 101
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char = ;code = 32
char = w;code = 119
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = c;code = 99
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = j;code = 106
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = v;code = 118
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = l;code = 108
char = u;code = 117
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Lung cancer remains a major health challenge in the world. It is the commonest cause of cancer mortality in men, it has been suggested that genetic susceptibility may contribute to the major risk factor, with increasing prevalence of smoking. Lung cancer has reached epidemic proportions in India. Recently indoor air pollution and dietary factors have been implicated in the causation of lung Cancer development. Accumulating evidences have highlighted that several polymorphisms involve the metabolic activation or detoxification of carcinogens derived from cigarette smoke have been found to be associated with lung cancer risk. Many studies have focused on the relation between the distribution of polymorphic variants of different forms of the metabolic enzymes and lung cancer susceptibility, Few of human biotransformating enzymes (PHASE I ENZYME: Cytochrome p450 enzymes, and

PHASE II ENZYMES: Glutathione-s-transferases, N-acetyltransferases) have been implicated in the formation and scavenging of ultimate reactive metabolites. These enzyme families are known to catalyze detoxification of electrophilic compounds including carcinogens. The treatment and prevention of lung cancer are major unmet needs that can probably be improved by a better understanding of the molecular origins and evolution of the disease. This review will focus on major recent advances in the molecular study of the origins and biology of lung cancer.

Publication: Niger J Med 2010 Jul-Sep ;19(3)::257-63.
Publication Date: 2010 Jul-Sep
Study Author(s): Shukla, R K;Kant, S;Mittal, B;Bhattacharya, S;
Institution: Department of Physiology, C. S. M. Medical University, Lucknow.
Shortcut link to this study:
Lung cancer remains a major health challenge in the world. It is the commonest cause of cancer mortality in men, it has been suggested that genetic susceptibility may contribute to the major risk factor, with increasing prevalence of smoking. Lung cancer has reached epidemic proportions in India. Recently indoor air pollution and dietary factors have been implicated in the causation of lung Cancer development. Accumulating evidences have highlighted that several polymorphisms involve the metabolic activation or detoxification of carcinogens derived from cigarette smoke have been found to be associated with lung cancer risk. Many studies have focused on the relation between the distribution of polymorphic variants of different forms of the metabolic enzymes and lung cancer susceptibility, Few of human biotransformating enzymes (PHASE I ENZYME: Cytochrome p450 enzymes, and

PHASE II ENZYMES: Glutathione-s-transferases, N-acetyltransferases) have been implicated in the formation and scavenging of ultimate reactive metabolites. These enzyme families are known to catalyze detoxification of electrophilic compounds including carcinogens. The treatment and prevention of lung cancer are major unmet needs that can probably be improved by a better understanding of the molecular origins and evolution of the disease. This review will focus on major recent advances in the molecular study of the origins and biology of lung cancer.
PMID: 20845626

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