|
|
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result sql = In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds.
In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds.char = O;code = 79
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char = l;code = 108
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char = d;code = 100
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char = f;code = 102
char = e;code = 101
char = r;code = 114
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char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = B;code = 66
char = T;code = 84
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = n;code = 110
char = o;code = 111
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char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
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char = f;code = 102
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result sql = Our aim was to investigate the effect of several dietary polyphenols on uptake of (14)C-butyrate ((14)C-BT) by Caco-2 cells and try to correlate this effect with the modulation of the anticarcinogenic effect of BT in these cells. Acutely, uptake of (14)C-BT (10 μM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, catechin, and epicatechin; and uptake of (14)C-BT (20 mM) was reduced by resveratrol, quercetin, myricetin, chrysin, EGCG, and epicatechin. Resveratrol acts as a competitive inhibitor of (14)C-BT uptake. Chronically, quercetin and EGCG increased uptake of (14)C-BT (10 μM), whereas myricetin, rutin, chrysin, and xanthohumol decreased it. Moreover, catechin (1 μM), quercetin, myricetin, rutin, EGCG, and chrysin increased uptake of (14)C-BT (20 mM), whereas catechin (0.1 μM) decreased it. EGCG, myricetin, and catechin decreased MCT1 mRNA expression, while chrysin increased it; quercetin, rutin, and xanthohumol had no effect. BT (5 mM; 48 h) markedly decreased cellular viability and proliferation and increased cell differentiation and apoptosis. In general, combination of polyphenolic compounds with BT did not significantly modify these changes. In conclusion, changes in uptake of BT induced by polyphenols do not correlate with changes on the effect of BT upon cell viability, cell proliferation, differentiation, and apoptosis.
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char = t;code = 116
char = r;code = 114
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char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
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char = l;code = 108
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char = b;code = 98
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char = u;code = 117
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char = d;code = 100
char = s;code = 115
char = .;code = 46
result sql = In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds.
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = B;code = 66
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char = ;code = 32
char = i;code = 105
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char = t;code = 116
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = A;code = 65
char = c;code = 99
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char = t;code = 116
char = e;code = 101
char = l;code = 108
char = y;code = 121
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char = a;code = 97
char = k;code = 107
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char = 1;code = 49
char = 4;code = 52
char = );code = 41
char = C;code = 67
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char = 1;code = 49
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char = 9;code = 57
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char = w;code = 119
char = a;code = 97
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char = d;code = 100
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char = a;code = 97
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char = d;code = 100
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char = s;code = 115
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = r;code = 114
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char = l;code = 108
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char = q;code = 113
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char = e;code = 101
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char = ,;code = 44
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char = m;code = 109
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char = a;code = 97
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char = d;code = 100
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = a;code = 97
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char = h;code = 104
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char = l;code = 108
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char = c;code = 99
char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = c;code = 99
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char = i;code = 105
char = n;code = 110
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char = a;code = 97
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char = d;code = 100
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char = u;code = 117
char = p;code = 112
char = t;code = 116
char = a;code = 97
char = k;code = 107
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 4;code = 52
char = );code = 41
char = C;code = 67
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char = B;code = 66
char = T;code = 84
char = ;code = 32
char = (;code = 40
char = 2;code = 50
char = 0;code = 48
char = ;code = 32
char = m;code = 109
char = M;code = 77
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char = w;code = 119
char = a;code = 97
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char = u;code = 117
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char = e;code = 101
char = d;code = 100
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char = b;code = 98
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char = r;code = 114
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char = s;code = 115
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = r;code = 114
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char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = q;code = 113
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char = e;code = 101
char = r;code = 114
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char = e;code = 101
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = m;code = 109
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char = r;code = 114
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char = c;code = 99
char = e;code = 101
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char = n;code = 110
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char = ;code = 32
char = c;code = 99
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char = r;code = 114
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = E;code = 69
char = G;code = 71
char = C;code = 67
char = G;code = 71
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char = ;code = 32
char = a;code = 97
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char = c;code = 99
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char = i;code = 105
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char = .;code = 46
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char = R;code = 82
char = e;code = 101
char = s;code = 115
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char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = r;code = 114
char = o;code = 111
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char = a;code = 97
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char = t;code = 116
char = s;code = 115
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = i;code = 105
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char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
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char = r;code = 114
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = 1;code = 49
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char = );code = 41
char = C;code = 67
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char = B;code = 66
char = T;code = 84
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char = u;code = 117
char = p;code = 112
char = t;code = 116
char = a;code = 97
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char = l;code = 108
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char = G;code = 71
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char = 5;code = 53
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char = E;code = 69
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char = C;code = 67
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char = N;code = 78
char = A;code = 65
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result sql = Our aim was to investigate the effect of several dietary polyphenols on uptake of (14)C-butyrate ((14)C-BT) by Caco-2 cells and try to correlate this effect with the modulation of the anticarcinogenic effect of BT in these cells. Acutely, uptake of (14)C-BT (10 μM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, catechin, and epicatechin; and uptake of (14)C-BT (20 mM) was reduced by resveratrol, quercetin, myricetin, chrysin, EGCG, and epicatechin. Resveratrol acts as a competitive inhibitor of (14)C-BT uptake. Chronically, quercetin and EGCG increased uptake of (14)C-BT (10 μM), whereas myricetin, rutin, chrysin, and xanthohumol decreased it. Moreover, catechin (1 μM), quercetin, myricetin, rutin, EGCG, and chrysin increased uptake of (14)C-BT (20 mM), whereas catechin (0.1 μM) decreased it. EGCG, myricetin, and catechin decreased MCT1 mRNA expression, while chrysin increased it; quercetin, rutin, and xanthohumol had no effect. BT (5 mM; 48 h) markedly decreased cellular viability and proliferation and increased cell differentiation and apoptosis. In general, combination of polyphenolic compounds with BT did not significantly modify these changes. In conclusion, changes in uptake of BT induced by polyphenols do not correlate with changes on the effect of BT upon cell viability, cell proliferation, differentiation, and apoptosis.
Publication: Nutr Cancer 2011 ;63(2)::282-94. :doi: 10.1080/01635581.2011.523166.
Publication Date: 2011
Study Author(s): Gonçalves, Pedro;Araújo, João R;Pinho, M João;Martel, Fátima;
Institution: Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal.
Shortcut link to this study:
Publication Date: 2011
Study Author(s): Gonçalves, Pedro;Araújo, João R;Pinho, M João;Martel, Fátima;
Institution: Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal.
Shortcut link to this study:
Our aim was to investigate the effect of several dietary polyphenols on uptake of (14)C-butyrate ((14)C-BT) by Caco-2 cells and try to correlate this effect with the modulation of the anticarcinogenic effect of BT in these cells. Acutely, uptake of (14)C-BT (10 μM) was decreased by resveratrol, quercetin, myricetin, and chrysin, and increased by xanthohumol, catechin, and epicatechin; and uptake of (14)C-BT (20 mM) was reduced by resveratrol, quercetin, myricetin, chrysin, EGCG, and epicatechin. Resveratrol acts as a competitive inhibitor of (14)C-BT uptake. Chronically, quercetin and EGCG increased uptake of (14)C-BT (10 μM), whereas myricetin, rutin, chrysin, and xanthohumol decreased it. Moreover, catechin (1 μM), quercetin, myricetin, rutin, EGCG, and chrysin increased uptake of (14)C-BT (20 mM), whereas catechin (0.1 μM) decreased it. EGCG, myricetin, and catechin decreased MCT1 mRNA expression, while chrysin increased it; quercetin, rutin, and xanthohumol had no effect. BT (5 mM; 48 h) markedly decreased cellular viability and proliferation and increased cell differentiation and apoptosis. In general, combination of polyphenolic compounds with BT did not significantly modify these changes. In conclusion, changes in uptake of BT induced by polyphenols do not correlate with changes on the effect of BT upon cell viability, cell proliferation, differentiation, and apoptosis.
PMID: 21207318
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