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result sql = Peptide fragments of beta-amyloid precursor protein: effects on parallel fiber-Purkinje cell synaptic transmission in rat cerebellum.
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result sql = The effects of peptide fragments of the beta-amyloid precursor protein (betaAPP) on parallel fiber (PF)-Purkinje cell synaptic transmission in the rat cerebellum were examined. Transient inward currents associated with calcium influx were induced by localized applications of the 105-amino acid carboxy-terminal fragment (CT105) of betaAPP to discrete dendritic regions of intact Purkinje cells. betaAPP and the amyloid beta (Abeta) peptide fragments Abeta1-16, Abeta25-35, and Abeta1-42 had little or no effect. Inward currents were also observed following applications of CT105 to isolated patches of somatic Purkinje cell membrane. All five proteins/peptides induced some depression of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor-mediated synaptic transmission between PFs and Purkinje cells, through a combination of pre- and postsynaptic effects. CT105 induced the greatest depression, which spread to distant synapses following local application and which was prevented by inhibition of nitric oxide synthase. These data indicate that CT fragments of the betaAPP can modulate AMPA-mediated glutamatergic synaptic transmission in the cerebellar cortex. These fragments may therefore be considered alternative candidates for some of the neurotoxic effects of Alzheimer's disease.
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result sql = Peptide fragments of beta-amyloid precursor protein: effects on parallel fiber-Purkinje cell synaptic transmission in rat cerebellum.
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char = p;code = 112
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char = c;code = 99
char = a;code = 97
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char = ;code = 32
char = t;code = 116
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char = c;code = 99
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char = b;code = 98
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char = y;code = 121
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char = e;code = 101
char = r;code = 114
char = m;code = 109
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char = a;code = 97
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char = a;code = 97
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char = m;code = 109
char = e;code = 101
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char = t;code = 116
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char = C;code = 67
char = T;code = 84
char = 1;code = 49
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char = 5;code = 53
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char = ;code = 32
char = o;code = 111
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char = a;code = 97
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char = P;code = 80
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char = o;code = 111
char = f;code = 102
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char = i;code = 105
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char = t;code = 116
char = a;code = 97
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char = P;code = 80
char = u;code = 117
char = r;code = 114
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = j;code = 106
char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
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char = b;code = 98
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char = a;code = 97
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char = P;code = 80
char = P;code = 80
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = t;code = 116
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char = e;code = 101
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char = a;code = 97
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char = i;code = 105
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char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = ;code = 32
char = (;code = 40
char = A;code = 65
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = ;code = 32
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char = p;code = 112
char = t;code = 116
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = f;code = 102
char = r;code = 114
char = a;code = 97
char = g;code = 103
char = m;code = 109
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = A;code = 65
char = b;code = 98
char = e;code = 101
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char = a;code = 97
char = 1;code = 49
char = -;code = 45
char = 1;code = 49
char = 6;code = 54
char = ,;code = 44
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char = A;code = 65
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char = e;code = 101
char = t;code = 116
char = a;code = 97
char = 2;code = 50
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char = -;code = 45
char = 3;code = 51
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char = ;code = 32
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char = d;code = 100
char = ;code = 32
char = A;code = 65
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char = e;code = 101
char = t;code = 116
char = a;code = 97
char = 1;code = 49
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char = 4;code = 52
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char = h;code = 104
char = a;code = 97
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char = ;code = 32
char = l;code = 108
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char = t;code = 116
char = t;code = 116
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char = o;code = 111
char = r;code = 114
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char = n;code = 110
char = o;code = 111
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = w;code = 119
char = a;code = 97
char = r;code = 114
char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = r;code = 114
char = r;code = 114
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char = t;code = 116
char = s;code = 115
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char = w;code = 119
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char = r;code = 114
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char = o;code = 111
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char = o;code = 111
char = b;code = 98
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char = r;code = 114
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char = e;code = 101
char = d;code = 100
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char = f;code = 102
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = a;code = 97
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char = p;code = 112
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = T;code = 84
char = 1;code = 49
char = 0;code = 48
char = 5;code = 53
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = s;code = 115
char = o;code = 111
char = l;code = 108
char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = s;code = 115
char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = i;code = 105
char = c;code = 99
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char = P;code = 80
char = u;code = 117
char = r;code = 114
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = j;code = 106
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char = l;code = 108
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char = m;code = 109
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char = a;code = 97
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char = e;code = 101
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char = A;code = 65
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char = l;code = 108
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char = f;code = 102
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char = ;code = 32
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char = e;code = 101
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char = a;code = 97
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char = e;code = 101
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char = A;code = 65
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char = P;code = 80
char = A;code = 65
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char = ;code = 32
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char = c;code = 99
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char = w;code = 119
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char = e;code = 101
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char = F;code = 70
char = s;code = 115
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char = a;code = 97
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char = j;code = 106
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char = f;code = 102
char = e;code = 101
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char = s;code = 115
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char = ;code = 32
char = C;code = 67
char = T;code = 84
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char = h;code = 104
char = a;code = 97
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char = C;code = 67
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char = a;code = 97
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char = P;code = 80
char = P;code = 80
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char = P;code = 80
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result sql = The effects of peptide fragments of the beta-amyloid precursor protein (betaAPP) on parallel fiber (PF)-Purkinje cell synaptic transmission in the rat cerebellum were examined. Transient inward currents associated with calcium influx were induced by localized applications of the 105-amino acid carboxy-terminal fragment (CT105) of betaAPP to discrete dendritic regions of intact Purkinje cells. betaAPP and the amyloid beta (Abeta) peptide fragments Abeta1-16, Abeta25-35, and Abeta1-42 had little or no effect. Inward currents were also observed following applications of CT105 to isolated patches of somatic Purkinje cell membrane. All five proteins/peptides induced some depression of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor-mediated synaptic transmission between PFs and Purkinje cells, through a combination of pre- and postsynaptic effects. CT105 induced the greatest depression, which spread to distant synapses following local application and which was prevented by inhibition of nitric oxide synthase. These data indicate that CT fragments of the betaAPP can modulate AMPA-mediated glutamatergic synaptic transmission in the cerebellar cortex. These fragments may therefore be considered alternative candidates for some of the neurotoxic effects of Alzheimer's disease.
Publication: J. Neurochem. 2000 Mar ;74(3)::1112-21.
Publication Date: 2000 Mar
Study Author(s): Hartell, N A;Suh, Y H;
Institution: Pharmaceutical Science Research Institute, Aston University, Birmingham, England. [email protected]
Shortcut link to this study:
Publication Date: 2000 Mar
Study Author(s): Hartell, N A;Suh, Y H;
Institution: Pharmaceutical Science Research Institute, Aston University, Birmingham, England. [email protected]
Shortcut link to this study:
The effects of peptide fragments of the beta-amyloid precursor protein (betaAPP) on parallel fiber (PF)-Purkinje cell synaptic transmission in the rat cerebellum were examined. Transient inward currents associated with calcium influx were induced by localized applications of the 105-amino acid carboxy-terminal fragment (CT105) of betaAPP to discrete dendritic regions of intact Purkinje cells. betaAPP and the amyloid beta (Abeta) peptide fragments Abeta1-16, Abeta25-35, and Abeta1-42 had little or no effect. Inward currents were also observed following applications of CT105 to isolated patches of somatic Purkinje cell membrane. All five proteins/peptides induced some depression of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor-mediated synaptic transmission between PFs and Purkinje cells, through a combination of pre- and postsynaptic effects. CT105 induced the greatest depression, which spread to distant synapses following local application and which was prevented by inhibition of nitric oxide synthase. These data indicate that CT fragments of the betaAPP can modulate AMPA-mediated glutamatergic synaptic transmission in the cerebellar cortex. These fragments may therefore be considered alternative candidates for some of the neurotoxic effects of Alzheimer's disease.
PMID: 10693943
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