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result sql = OBJECTIVE : To determine if a causal connection exists between food additives and various medical complaints.
DESIGN : Literature study.
METHOD : Medline over the period January 1966-January 1999 was searched for articles on the following substances not containing protein and lactose: monosodium glutamate (MSG), sulfites, azo-dyes (tartrazine, sunset yellow, azorubin, amarant, cochineal red), benzoates, sorbates, butylated hydroxyanisole/butylated hydroxytoluene (BHA/BHT), parabens, cinnamon and vanilla, in combination with key words regarding food and side effects. Of those studies purporting to demonstrate an effect, only double-blind randomized placebo-controlled studies with oral challenge were assessed further, unless the complaint was anaphylaxis. Of studies not demonstrating an effect the design was assessed.
RESULTS : Only for sulfites as causative agents of asthma and anaphylaxis, methodologically adequate studies demonstrating a causal connection could be found. For azo-dyes, benzoates, MSG, sorbates and BHA/BHT, no link with medical symptoms was demonstrable. For parabens, cinnamon and vanilla there were insufficient or inadequate data to justify a conclusion.
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result sql = [Food additives as a cause of medical symptoms: relationship shown between sulfites and asthma and anaphylaxis; results of a literature review].
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char = i;code = 105
char = n;code = 110
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char = s;code = 115
char = t;code = 116
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char = c;code = 99
char = e;code = 101
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char = c;code = 99
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char = a;code = 97
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char = n;code = 110
char = i;code = 105
char = n;code = 110
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char = o;code = 111
char = t;code = 116
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char = i;code = 105
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char = a;code = 97
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char = d;code = 100
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char = l;code = 108
char = a;code = 97
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char = t;code = 116
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char = s;code = 115
char = e;code = 101
char = :;code = 58
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char = m;code = 109
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char = n;code = 110
char = o;code = 111
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char = o;code = 111
char = d;code = 100
char = i;code = 105
char = u;code = 117
char = m;code = 109
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char = g;code = 103
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char = u;code = 117
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = M;code = 77
char = S;code = 83
char = G;code = 71
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = f;code = 102
char = i;code = 105
char = t;code = 116
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char = a;code = 97
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char = o;code = 111
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char = d;code = 100
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char = s;code = 115
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char = (;code = 40
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = r;code = 114
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char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = s;code = 115
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char = e;code = 101
char = t;code = 116
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char = y;code = 121
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char = l;code = 108
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = z;code = 122
char = o;code = 111
char = r;code = 114
char = u;code = 117
char = b;code = 98
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = a;code = 97
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = c;code = 99
char = h;code = 104
char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = n;code = 110
char = z;code = 122
char = o;code = 111
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = o;code = 111
char = r;code = 114
char = b;code = 98
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = y;code = 121
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = /;code = 47
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = y;code = 121
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = B;code = 66
char = H;code = 72
char = A;code = 65
char = /;code = 47
char = B;code = 66
char = H;code = 72
char = T;code = 84
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = a;code = 97
char = b;code = 98
char = e;code = 101
char = n;code = 110
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = n;code = 110
char = a;code = 97
char = m;code = 109
char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = v;code = 118
char = a;code = 97
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char = i;code = 105
char = l;code = 108
char = l;code = 108
char = a;code = 97
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = b;code = 98
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = k;code = 107
char = e;code = 101
char = y;code = 121
char = ;code = 32
char = w;code = 119
char = o;code = 111
char = r;code = 114
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = a;code = 97
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char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = o;code = 111
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = O;code = 79
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = p;code = 112
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char = r;code = 114
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = d;code = 100
char = e;code = 101
char = m;code = 109
char = o;code = 111
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = a;code = 97
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = t;code = 116
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char = ;code = 32
char = o;code = 111
char = n;code = 110
char = l;code = 108
char = y;code = 121
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char = d;code = 100
char = o;code = 111
char = u;code = 117
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = -;code = 45
char = b;code = 98
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = ;code = 32
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char = d;code = 100
char = o;code = 111
char = m;code = 109
char = i;code = 105
char = z;code = 122
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char = a;code = 97
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char = c;code = 99
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char = r;code = 114
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char = l;code = 108
char = e;code = 101
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char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = a;code = 97
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char = c;code = 99
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char = a;code = 97
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char = l;code = 108
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char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
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char = f;code = 102
char = u;code = 117
char = r;code = 114
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char = h;code = 104
char = e;code = 101
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char = ,;code = 44
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char = u;code = 117
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char = l;code = 108
char = e;code = 101
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char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = c;code = 99
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char = m;code = 109
char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = n;code = 110
char = t;code = 116
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char = w;code = 119
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char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = h;code = 104
char = y;code = 121
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char = a;code = 97
char = x;code = 120
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = O;code = 79
char = f;code = 102
char = ;code = 32
char = s;code = 115
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char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
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char = e;code = 101
char = m;code = 109
char = o;code = 111
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char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = d;code = 100
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char = s;code = 115
char = i;code = 105
char = g;code = 103
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = .;code = 46
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char = b;code = 98
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = O;code = 79
char = n;code = 110
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = s;code = 115
char = u;code = 117
char = l;code = 108
char = f;code = 102
char = i;code = 105
char = t;code = 116
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char = a;code = 97
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char = c;code = 99
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char = s;code = 115
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char = v;code = 118
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char = c;code = 99
char = t;code = 116
char = i;code = 105
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char = o;code = 111
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char = l;code = 108
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char = b;code = 98
char = e;code = 101
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char = f;code = 102
char = o;code = 111
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char = n;code = 110
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char = .;code = 46
char = ;code = 32
char = F;code = 70
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = z;code = 122
char = o;code = 111
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char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = M;code = 77
char = S;code = 83
char = G;code = 71
char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = o;code = 111
char = r;code = 114
char = b;code = 98
char = a;code = 97
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = B;code = 66
char = H;code = 72
char = A;code = 65
char = /;code = 47
char = B;code = 66
char = H;code = 72
char = T;code = 84
char = ,;code = 44
char = ;code = 32
char = n;code = 110
char = o;code = 111
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char = l;code = 108
char = i;code = 105
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char = k;code = 107
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = a;code = 97
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char = s;code = 115
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char = p;code = 112
char = t;code = 116
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char = s;code = 115
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char = a;code = 97
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char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = F;code = 70
char = o;code = 111
char = r;code = 114
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char = p;code = 112
char = a;code = 97
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char = a;code = 97
char = b;code = 98
char = e;code = 101
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char = s;code = 115
char = ,;code = 44
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char = n;code = 110
char = a;code = 97
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char = o;code = 111
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char = v;code = 118
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char = i;code = 105
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char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = u;code = 117
char = f;code = 102
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = d;code = 100
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = j;code = 106
char = u;code = 117
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = f;code = 102
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
result sql = OBJECTIVE : To determine if a causal connection exists between food additives and various medical complaints.
DESIGN : Literature study.
METHOD : Medline over the period January 1966-January 1999 was searched for articles on the following substances not containing protein and lactose: monosodium glutamate (MSG), sulfites, azo-dyes (tartrazine, sunset yellow, azorubin, amarant, cochineal red), benzoates, sorbates, butylated hydroxyanisole/butylated hydroxytoluene (BHA/BHT), parabens, cinnamon and vanilla, in combination with key words regarding food and side effects. Of those studies purporting to demonstrate an effect, only double-blind randomized placebo-controlled studies with oral challenge were assessed further, unless the complaint was anaphylaxis. Of studies not demonstrating an effect the design was assessed.
RESULTS : Only for sulfites as causative agents of asthma and anaphylaxis, methodologically adequate studies demonstrating a causal connection could be found. For azo-dyes, benzoates, MSG, sorbates and BHA/BHT, no link with medical symptoms was demonstrable. For parabens, cinnamon and vanilla there were insufficient or inadequate data to justify a conclusion.
Publication: Ned Tijdschr Geneeskd 2000 Sep 16 ;144(38)::1836-9.
Publication Date: 2000 Sep 16
Study Author(s): Reus, K E;Houben, G F;Stam, M;Dubois, A E;
Institution: Academisch Ziekenhuis, afd. Allergologie, Groningen.
Shortcut link to this study:
Publication Date: 2000 Sep 16
Study Author(s): Reus, K E;Houben, G F;Stam, M;Dubois, A E;
Institution: Academisch Ziekenhuis, afd. Allergologie, Groningen.
Shortcut link to this study:
OBJECTIVE : To determine if a causal connection exists between food additives and various medical complaints.
DESIGN : Literature study.
METHOD : Medline over the period January 1966-January 1999 was searched for articles on the following substances not containing protein and lactose: monosodium glutamate (MSG), sulfites, azo-dyes (tartrazine, sunset yellow, azorubin, amarant, cochineal red), benzoates, sorbates, butylated hydroxyanisole/butylated hydroxytoluene (BHA/BHT), parabens, cinnamon and vanilla, in combination with key words regarding food and side effects. Of those studies purporting to demonstrate an effect, only double-blind randomized placebo-controlled studies with oral challenge were assessed further, unless the complaint was anaphylaxis. Of studies not demonstrating an effect the design was assessed.
RESULTS : Only for sulfites as causative agents of asthma and anaphylaxis, methodologically adequate studies demonstrating a causal connection could be found. For azo-dyes, benzoates, MSG, sorbates and BHA/BHT, no link with medical symptoms was demonstrable. For parabens, cinnamon and vanilla there were insufficient or inadequate data to justify a conclusion.
DESIGN : Literature study.
METHOD : Medline over the period January 1966-January 1999 was searched for articles on the following substances not containing protein and lactose: monosodium glutamate (MSG), sulfites, azo-dyes (tartrazine, sunset yellow, azorubin, amarant, cochineal red), benzoates, sorbates, butylated hydroxyanisole/butylated hydroxytoluene (BHA/BHT), parabens, cinnamon and vanilla, in combination with key words regarding food and side effects. Of those studies purporting to demonstrate an effect, only double-blind randomized placebo-controlled studies with oral challenge were assessed further, unless the complaint was anaphylaxis. Of studies not demonstrating an effect the design was assessed.
RESULTS : Only for sulfites as causative agents of asthma and anaphylaxis, methodologically adequate studies demonstrating a causal connection could be found. For azo-dyes, benzoates, MSG, sorbates and BHA/BHT, no link with medical symptoms was demonstrable. For parabens, cinnamon and vanilla there were insufficient or inadequate data to justify a conclusion.
PMID: 11020839
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