|
|
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result sql = Restless legs syndrome: a clinical study of 55 patients.
Restless legs syndrome: a clinical study of 55 patients.char = <;code = 60
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result sql = BACKGROUND : Restless legs syndrome (RLS) is a common sleep disorder. In 1995, clinical criteria for the diagnosis of RLS were defined.
OBJECTIVE : To describe the clinical spectrum in a series of unselected RLS patients meeting the new diagnostic criteria.
METHODS : We prospectively assessed by questionnaire and clinical assessment the characteristics of 55 consecutive RLS patients (35 women, 20 men; mean age = 62 +/- 16 years).
RESULTS : In 27% of the patients, RLS started before the age of 20 years (early-onset RLS). Sensory disturbances were painful in 56% of patients and felt in legs (98%), arms (35%), and 'internally' (45%). Motor disturbances included 'dyskinesias while awake' (36%). Insomnia (58%) was commoner than hypersomnia (24%). In 67% of the patients, no etiology of RLS was found (idiopathic RLS). Early-onset RLS was more commonly familial (p = 0.01) and associated with 'growing pains' (p = 0.005) than late-onset RLS. Patients with RLS and hypersomnia were younger (p = 0.01) and less commonly had painful sensations (p = 0.04) than patients with RLS and insomnia. Patients with idiopathic RLS were younger (p = 0.004), and less commonly had insomnia (p = 0.01) than patients with symptomatic RLS.
CONCLUSIONS : RLS is a clinically pleomorphic syndrome, reflecting the contribution of multiple genetic and acquired factors in the pathogenesis of RLS.
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result sql = Restless legs syndrome: a clinical study of 55 patients.
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char = s;code = 115
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char = c;code = 99
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char = c;code = 99
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char = t;code = 116
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char = i;code = 105
char = a;code = 97
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char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = M;code = 77
char = E;code = 69
char = T;code = 84
char = H;code = 72
char = O;code = 79
char = D;code = 68
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
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char = i;code = 105
char = v;code = 118
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char = l;code = 108
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
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char = q;code = 113
char = u;code = 117
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = n;code = 110
char = a;code = 97
char = i;code = 105
char = r;code = 114
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
char = l;code = 108
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char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
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char = s;code = 115
char = s;code = 115
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = t;code = 116
char = h;code = 104
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char = c;code = 99
char = h;code = 104
char = a;code = 97
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 5;code = 53
char = 5;code = 53
char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = s;code = 115
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = R;code = 82
char = L;code = 76
char = S;code = 83
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
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char = s;code = 115
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char = (;code = 40
char = 3;code = 51
char = 5;code = 53
char = ;code = 32
char = w;code = 119
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = 2;code = 50
char = 0;code = 48
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char = m;code = 109
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char = n;code = 110
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char = m;code = 109
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char = a;code = 97
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
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char = =;code = 61
char = ;code = 32
char = 6;code = 54
char = 2;code = 50
char = ;code = 32
char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 1;code = 49
char = 6;code = 54
char = ;code = 32
char = y;code = 121
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = s;code = 115
char = );code = 41
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = 2;code = 50
char = 7;code = 55
char = %;code = 37
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
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char = s;code = 115
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char = ;code = 32
char = R;code = 82
char = L;code = 76
char = S;code = 83
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = f;code = 102
char = o;code = 111
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 2;code = 50
char = 0;code = 48
char = ;code = 32
char = y;code = 121
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char = a;code = 97
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char = s;code = 115
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char = (;code = 40
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = l;code = 108
char = y;code = 121
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char = o;code = 111
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = t;code = 116
char = ;code = 32
char = R;code = 82
char = L;code = 76
char = S;code = 83
char = );code = 41
char = .;code = 46
char = ;code = 32
char = S;code = 83
char = e;code = 101
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char = s;code = 115
char = o;code = 111
char = r;code = 114
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char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = r;code = 114
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char = a;code = 97
char = n;code = 110
char = c;code = 99
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char = s;code = 115
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char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = p;code = 112
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = f;code = 102
char = u;code = 117
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = 5;code = 53
char = 6;code = 54
char = %;code = 37
char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = f;code = 102
char = e;code = 101
char = l;code = 108
char = t;code = 116
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char = i;code = 105
char = n;code = 110
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char = l;code = 108
char = e;code = 101
char = g;code = 103
char = s;code = 115
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char = 8;code = 56
char = %;code = 37
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = m;code = 109
char = s;code = 115
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char = %;code = 37
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char = ,;code = 44
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char = a;code = 97
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char = a;code = 97
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char = l;code = 108
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char = (;code = 40
char = 4;code = 52
char = 5;code = 53
char = %;code = 37
char = );code = 41
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = o;code = 111
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char = o;code = 111
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char = ;code = 32
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char = i;code = 105
char = s;code = 115
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char = a;code = 97
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char = ;code = 32
char = (;code = 40
char = 3;code = 51
char = 6;code = 54
char = %;code = 37
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char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = n;code = 110
char = i;code = 105
char = a;code = 97
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char = 5;code = 53
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char = %;code = 37
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char = ;code = 32
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char = m;code = 109
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char = (;code = 40
char = 2;code = 50
char = 4;code = 52
char = %;code = 37
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char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
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char = 6;code = 54
char = 7;code = 55
char = %;code = 37
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char = o;code = 111
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char = o;code = 111
char = g;code = 103
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = R;code = 82
char = L;code = 76
char = S;code = 83
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char = w;code = 119
char = a;code = 97
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char = ;code = 32
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char = a;code = 97
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char = i;code = 105
char = c;code = 99
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char = R;code = 82
char = L;code = 76
char = S;code = 83
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char = .;code = 46
char = ;code = 32
char = E;code = 69
char = a;code = 97
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char = l;code = 108
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char = o;code = 111
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char = w;code = 119
char = a;code = 97
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char = R;code = 82
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char = S;code = 83
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char = ;code = 32
char = P;code = 80
char = a;code = 97
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char = a;code = 97
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char = p;code = 112
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char = a;code = 97
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char = =;code = 61
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char = 0;code = 48
char = .;code = 46
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char = 4;code = 52
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char = a;code = 97
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = R;code = 82
char = L;code = 76
char = S;code = 83
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char = a;code = 97
char = n;code = 110
char = d;code = 100
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char = a;code = 97
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char = P;code = 80
char = a;code = 97
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char = e;code = 101
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char = s;code = 115
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char = a;code = 97
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = R;code = 82
char = L;code = 76
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = y;code = 121
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char = e;code = 101
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = p;code = 112
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char = 4;code = 52
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char = ;code = 32
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char = d;code = 100
char = ;code = 32
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char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
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char = o;code = 111
char = m;code = 109
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = n;code = 110
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = (;code = 40
char = p;code = 112
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 1;code = 49
char = );code = 41
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = R;code = 82
char = L;code = 76
char = S;code = 83
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
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char = C;code = 67
char = L;code = 76
char = U;code = 85
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char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = L;code = 76
char = S;code = 83
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
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char = i;code = 105
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char = l;code = 108
char = y;code = 121
char = ;code = 32
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char = o;code = 111
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char = p;code = 112
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = r;code = 114
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char = f;code = 102
char = l;code = 108
char = e;code = 101
char = c;code = 99
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char = n;code = 110
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = i;code = 105
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = q;code = 113
char = u;code = 117
char = i;code = 105
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = R;code = 82
char = L;code = 76
char = S;code = 83
char = .;code = 46
result sql = BACKGROUND : Restless legs syndrome (RLS) is a common sleep disorder. In 1995, clinical criteria for the diagnosis of RLS were defined.
OBJECTIVE : To describe the clinical spectrum in a series of unselected RLS patients meeting the new diagnostic criteria.
METHODS : We prospectively assessed by questionnaire and clinical assessment the characteristics of 55 consecutive RLS patients (35 women, 20 men; mean age = 62 +/- 16 years).
RESULTS : In 27% of the patients, RLS started before the age of 20 years (early-onset RLS). Sensory disturbances were painful in 56% of patients and felt in legs (98%), arms (35%), and 'internally' (45%). Motor disturbances included 'dyskinesias while awake' (36%). Insomnia (58%) was commoner than hypersomnia (24%). In 67% of the patients, no etiology of RLS was found (idiopathic RLS). Early-onset RLS was more commonly familial (p = 0.01) and associated with 'growing pains' (p = 0.005) than late-onset RLS. Patients with RLS and hypersomnia were younger (p = 0.01) and less commonly had painful sensations (p = 0.04) than patients with RLS and insomnia. Patients with idiopathic RLS were younger (p = 0.004), and less commonly had insomnia (p = 0.01) than patients with symptomatic RLS.
CONCLUSIONS : RLS is a clinically pleomorphic syndrome, reflecting the contribution of multiple genetic and acquired factors in the pathogenesis of RLS.
Publication: Eur. Neurol. 2001 ;45(2)::67-74.
Publication Date: 2001
Study Author(s): Bassetti, C L;Mauerhofer, D;Gugger, M;Mathis, J;Hess, C W;
Institution: Department of Neurology, University Hospital (Inselspital), Bern, Switzerland. [email protected]
Shortcut link to this study:
Publication Date: 2001
Study Author(s): Bassetti, C L;Mauerhofer, D;Gugger, M;Mathis, J;Hess, C W;
Institution: Department of Neurology, University Hospital (Inselspital), Bern, Switzerland. [email protected]
Shortcut link to this study:
BACKGROUND : Restless legs syndrome (RLS) is a common sleep disorder. In 1995, clinical criteria for the diagnosis of RLS were defined.
OBJECTIVE : To describe the clinical spectrum in a series of unselected RLS patients meeting the new diagnostic criteria.
METHODS : We prospectively assessed by questionnaire and clinical assessment the characteristics of 55 consecutive RLS patients (35 women, 20 men; mean age = 62 +/- 16 years).
RESULTS : In 27% of the patients, RLS started before the age of 20 years (early-onset RLS). Sensory disturbances were painful in 56% of patients and felt in legs (98%), arms (35%), and 'internally' (45%). Motor disturbances included 'dyskinesias while awake' (36%). Insomnia (58%) was commoner than hypersomnia (24%). In 67% of the patients, no etiology of RLS was found (idiopathic RLS). Early-onset RLS was more commonly familial (p = 0.01) and associated with 'growing pains' (p = 0.005) than late-onset RLS. Patients with RLS and hypersomnia were younger (p = 0.01) and less commonly had painful sensations (p = 0.04) than patients with RLS and insomnia. Patients with idiopathic RLS were younger (p = 0.004), and less commonly had insomnia (p = 0.01) than patients with symptomatic RLS.
CONCLUSIONS : RLS is a clinically pleomorphic syndrome, reflecting the contribution of multiple genetic and acquired factors in the pathogenesis of RLS.
OBJECTIVE : To describe the clinical spectrum in a series of unselected RLS patients meeting the new diagnostic criteria.
METHODS : We prospectively assessed by questionnaire and clinical assessment the characteristics of 55 consecutive RLS patients (35 women, 20 men; mean age = 62 +/- 16 years).
RESULTS : In 27% of the patients, RLS started before the age of 20 years (early-onset RLS). Sensory disturbances were painful in 56% of patients and felt in legs (98%), arms (35%), and 'internally' (45%). Motor disturbances included 'dyskinesias while awake' (36%). Insomnia (58%) was commoner than hypersomnia (24%). In 67% of the patients, no etiology of RLS was found (idiopathic RLS). Early-onset RLS was more commonly familial (p = 0.01) and associated with 'growing pains' (p = 0.005) than late-onset RLS. Patients with RLS and hypersomnia were younger (p = 0.01) and less commonly had painful sensations (p = 0.04) than patients with RLS and insomnia. Patients with idiopathic RLS were younger (p = 0.004), and less commonly had insomnia (p = 0.01) than patients with symptomatic RLS.
CONCLUSIONS : RLS is a clinically pleomorphic syndrome, reflecting the contribution of multiple genetic and acquired factors in the pathogenesis of RLS.
PMID: 11244268
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