|
|
char = [;code = 91
char = D;code = 68
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = C;code = 67
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char = y;code = 121
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char = H;code = 72
char = P;code = 80
char = L;code = 76
char = C;code = 67
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = h;code = 104
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char = a;code = 97
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char = c;code = 99
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char = n;code = 110
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char = n;code = 110
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char = t;code = 116
char = e;code = 101
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = ];code = 93
char = .;code = 46
result sql = [Determination of sinomenine HCl in serum and urine by HPLC and its pharmacokinetics in normal volunteers].
[Determination of sinomenine HCl in serum and urine by HPLC and its pharmacokinetics in normal volunteers].char = A;code = 65
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char = R;code = 82
char = P;code = 80
char = -;code = 45
char = H;code = 72
char = P;code = 80
char = L;code = 76
char = C;code = 67
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char = ;code = 32
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char = e;code = 101
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char = e;code = 101
char = l;code = 108
char = o;code = 111
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = d;code = 100
char = e;code = 101
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char = e;code = 101
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char = m;code = 109
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = c;code = 99
char = o;code = 111
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char = r;code = 114
char = a;code = 97
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char = i;code = 105
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char = f;code = 102
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char = s;code = 115
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char = d;code = 100
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
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char = h;code = 104
char = e;code = 101
char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = y;code = 121
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char = v;code = 118
char = o;code = 111
char = l;code = 108
char = u;code = 117
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = e;code = 101
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char = .;code = 46
char = ;code = 32
char = C;code = 67
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char = 8;code = 56
char = H;code = 72
char = 3;code = 51
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char = ;code = 32
char = c;code = 99
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char = l;code = 108
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = h;code = 104
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = b;code = 98
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char = l;code = 108
char = e;code = 101
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char = p;code = 112
char = h;code = 104
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = e;code = 101
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char = o;code = 111
char = n;code = 110
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char = r;code = 114
char = i;code = 105
char = l;code = 108
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char = -;code = 45
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char = 0;code = 48
char = 1;code = 49
char = ;code = 32
char = m;code = 109
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char = .;code = 46
char = L;code = 76
char = -;code = 45
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char = s;code = 115
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char = d;code = 100
char = i;code = 105
char = u;code = 117
char = m;code = 109
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char = o;code = 111
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = i;code = 105
char = c;code = 99
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char = -;code = 45
char = N;code = 78
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char = ;code = 32
char = N;code = 78
char = ,;code = 44
char = ;code = 32
char = N;code = 78
char = ';code = 39
char = ,;code = 44
char = ;code = 32
char = N;code = 78
char = ';code = 39
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char = (;code = 40
char = 4;code = 52
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char = :;code = 58
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char = 2;code = 50
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char = ,;code = 44
char = ;code = 32
char = p;code = 112
char = H;code = 72
char = ;code = 32
char = 6;code = 54
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char = 9;code = 57
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = u;code = 117
char = l;code = 108
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = v;code = 118
char = i;code = 105
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char = ;code = 32
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char = b;code = 98
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char = o;code = 111
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = m;code = 109
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char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = ;code = 32
char = 2;code = 50
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char = n;code = 110
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char = .;code = 46
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char = T;code = 84
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char = a;code = 97
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char = o;code = 111
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char = n;code = 110
char = ;code = 32
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = i;code = 105
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char = t;code = 116
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char = r;code = 114
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char = a;code = 97
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char = ;code = 32
char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = d;code = 100
char = .;code = 46
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char = e;code = 101
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char = m;code = 109
char = ;code = 32
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char = o;code = 111
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = n;code = 110
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char = r;code = 114
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char = t;code = 116
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char = o;code = 111
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char = -;code = 45
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char = s;code = 115
char = ;code = 32
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char = ;code = 32
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char = o;code = 111
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char = ;code = 32
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char = o;code = 111
char = r;code = 114
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char = e;code = 101
char = r;code = 114
char = ;code = 32
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = ;code = 32
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char = b;code = 98
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char = H;code = 72
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char = A;code = 65
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char = R;code = 82
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char = /;code = 47
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char = ;code = 32
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char = .;code = 46
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char = 1;code = 49
char = ;code = 32
char = h;code = 104
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char = ;code = 32
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char = 1;code = 49
char = /;code = 47
char = 2;code = 50
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result sql = A RP-HPLC method was developed to determine the concentrations of sinomenine HCl in serum and urine and its pharmacokinetics was studied in healthy volunteers. C18H37 column was eluted with the mobile phase of acetonitrile--0.01 mol.L-1 sodium phosphate monobasic--N, N, N', N'-tetramethylenediamine (46:54:0.22 v/v, pH 6.9) and the ultraviolet absorbance was monitored at 263 nm. Triazolan was used as internal standard. The calibration curves were linear in the range of 6-480 ng.ml-1 in serum and 0.06-3 micrograms.ml-1 in urine, with mean recoveries of 75.46% and 91.38% respectively. The lowest detectable limits were 4 ng.ml-1 in serum and 40 ng.ml-1 in urine and the RSD for the intra-day and inter-day were less than 5%. A single oral dose of 80 mg sinomenine HCl tablet was given to 8 healthy male volunteers. The concentrations of sinomenine HCl in serum and urine were determined. The serum concentration--time curve was found to fit a two-compartment open model with first order elimination. THE PHARMACOKINETIC PARAMETERS WERE: T1/2 alpha 0.791 +/- 0.491 h, T1/2 beta 9.397 +/- 2.425 h, Tmax 1.040 +/- 0.274 h, Cmax 246.604 +/- 71.165 ng.ml-1, AUC 2651.158 +/- 1039.050 ng.h.ml-1, CL 0.033 +/- 0.010 ng.ml-1.
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = H;code = 72
char = C;code = 67
char = l;code = 108
char = ;code = 32
char = i;code = 105
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result sql = [Determination of sinomenine HCl in serum and urine by HPLC and its pharmacokinetics in normal volunteers].
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char = r;code = 114
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char = .;code = 46
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char = e;code = 101
char = c;code = 99
char = o;code = 111
char = v;code = 118
char = e;code = 101
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char = l;code = 108
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char = e;code = 101
char = c;code = 99
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char = m;code = 109
char = i;code = 105
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
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char = ;code = 32
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char = g;code = 103
char = .;code = 46
char = m;code = 109
char = l;code = 108
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char = i;code = 105
char = n;code = 110
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char = s;code = 115
char = e;code = 101
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char = d;code = 100
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char = .;code = 46
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char = ;code = 32
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = R;code = 82
char = S;code = 83
char = D;code = 68
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = r;code = 114
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char = d;code = 100
char = ;code = 32
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char = n;code = 110
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char = a;code = 97
char = y;code = 121
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char = e;code = 101
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char = e;code = 101
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
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char = 5;code = 53
char = %;code = 37
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = ;code = 32
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char = g;code = 103
char = ;code = 32
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char = n;code = 110
char = o;code = 111
char = m;code = 109
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char = n;code = 110
char = i;code = 105
char = n;code = 110
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char = l;code = 108
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char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = t;code = 116
char = ;code = 32
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char = a;code = 97
char = s;code = 115
char = ;code = 32
char = g;code = 103
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = 8;code = 56
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = v;code = 118
char = o;code = 111
char = l;code = 108
char = u;code = 117
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = o;code = 111
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char = c;code = 99
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char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = H;code = 72
char = C;code = 67
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = -;code = 45
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = t;code = 116
char = w;code = 119
char = o;code = 111
char = -;code = 45
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = p;code = 112
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = r;code = 114
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = T;code = 84
char = H;code = 72
char = E;code = 69
char = ;code = 32
char = P;code = 80
char = H;code = 72
char = A;code = 65
char = R;code = 82
char = M;code = 77
char = A;code = 65
char = C;code = 67
char = O;code = 79
char = K;code = 75
char = I;code = 73
char = N;code = 78
char = E;code = 69
char = T;code = 84
char = I;code = 73
char = C;code = 67
char = ;code = 32
char = P;code = 80
char = A;code = 65
char = R;code = 82
char = A;code = 65
char = M;code = 77
char = E;code = 69
char = T;code = 84
char = E;code = 69
char = R;code = 82
char = S;code = 83
char = ;code = 32
char = W;code = 87
char = E;code = 69
char = R;code = 82
char = E;code = 69
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = T;code = 84
char = 1;code = 49
char = /;code = 47
char = 2;code = 50
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 7;code = 55
char = 9;code = 57
char = 1;code = 49
char = ;code = 32
char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 4;code = 52
char = 9;code = 57
char = 1;code = 49
char = ;code = 32
char = h;code = 104
char = ,;code = 44
char = ;code = 32
char = T;code = 84
char = 1;code = 49
char = /;code = 47
char = 2;code = 50
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = ;code = 32
char = 9;code = 57
char = .;code = 46
char = 3;code = 51
char = 9;code = 57
char = 7;code = 55
char = ;code = 32
char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 2;code = 50
char = .;code = 46
char = 4;code = 52
char = 2;code = 50
char = 5;code = 53
char = ;code = 32
char = h;code = 104
char = ,;code = 44
char = ;code = 32
char = T;code = 84
char = m;code = 109
char = a;code = 97
char = x;code = 120
char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 0;code = 48
char = 4;code = 52
char = 0;code = 48
char = ;code = 32
char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 2;code = 50
char = 7;code = 55
char = 4;code = 52
char = ;code = 32
char = h;code = 104
char = ,;code = 44
char = ;code = 32
char = C;code = 67
char = m;code = 109
char = a;code = 97
char = x;code = 120
char = ;code = 32
char = 2;code = 50
char = 4;code = 52
char = 6;code = 54
char = .;code = 46
char = 6;code = 54
char = 0;code = 48
char = 4;code = 52
char = ;code = 32
char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 7;code = 55
char = 1;code = 49
char = .;code = 46
char = 1;code = 49
char = 6;code = 54
char = 5;code = 53
char = ;code = 32
char = n;code = 110
char = g;code = 103
char = .;code = 46
char = m;code = 109
char = l;code = 108
char = -;code = 45
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = A;code = 65
char = U;code = 85
char = C;code = 67
char = ;code = 32
char = 2;code = 50
char = 6;code = 54
char = 5;code = 53
char = 1;code = 49
char = .;code = 46
char = 1;code = 49
char = 5;code = 53
char = 8;code = 56
char = ;code = 32
char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = 3;code = 51
char = 9;code = 57
char = .;code = 46
char = 0;code = 48
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = n;code = 110
char = g;code = 103
char = .;code = 46
char = h;code = 104
char = .;code = 46
char = m;code = 109
char = l;code = 108
char = -;code = 45
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = C;code = 67
char = L;code = 76
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 3;code = 51
char = 3;code = 51
char = ;code = 32
char = +;code = 43
char = /;code = 47
char = -;code = 45
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 1;code = 49
char = 0;code = 48
char = ;code = 32
char = n;code = 110
char = g;code = 103
char = .;code = 46
char = m;code = 109
char = l;code = 108
char = -;code = 45
char = 1;code = 49
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = A RP-HPLC method was developed to determine the concentrations of sinomenine HCl in serum and urine and its pharmacokinetics was studied in healthy volunteers. C18H37 column was eluted with the mobile phase of acetonitrile--0.01 mol.L-1 sodium phosphate monobasic--N, N, N', N'-tetramethylenediamine (46:54:0.22 v/v, pH 6.9) and the ultraviolet absorbance was monitored at 263 nm. Triazolan was used as internal standard. The calibration curves were linear in the range of 6-480 ng.ml-1 in serum and 0.06-3 micrograms.ml-1 in urine, with mean recoveries of 75.46% and 91.38% respectively. The lowest detectable limits were 4 ng.ml-1 in serum and 40 ng.ml-1 in urine and the RSD for the intra-day and inter-day were less than 5%. A single oral dose of 80 mg sinomenine HCl tablet was given to 8 healthy male volunteers. The concentrations of sinomenine HCl in serum and urine were determined. The serum concentration--time curve was found to fit a two-compartment open model with first order elimination. THE PHARMACOKINETIC PARAMETERS WERE: T1/2 alpha 0.791 +/- 0.491 h, T1/2 beta 9.397 +/- 2.425 h, Tmax 1.040 +/- 0.274 h, Cmax 246.604 +/- 71.165 ng.ml-1, AUC 2651.158 +/- 1039.050 ng.h.ml-1, CL 0.033 +/- 0.010 ng.ml-1.
Publication: Yao Xue Xue Bao 1997 Aug ;32(8)::620-4.
Publication Date: 1997 Aug
Study Author(s): Yan, X H;Li, H D;Peng, W X;Liu, F Q;Shao, Y;He, Y Q;
Institution: Clinical Pharmacy Laboratory, 2nd Affiliated Hospital, Hunan Medical University, Changsha 410011.
Shortcut link to this study:
Publication Date: 1997 Aug
Study Author(s): Yan, X H;Li, H D;Peng, W X;Liu, F Q;Shao, Y;He, Y Q;
Institution: Clinical Pharmacy Laboratory, 2nd Affiliated Hospital, Hunan Medical University, Changsha 410011.
Shortcut link to this study:
A RP-HPLC method was developed to determine the concentrations of sinomenine HCl in serum and urine and its pharmacokinetics was studied in healthy volunteers. C18H37 column was eluted with the mobile phase of acetonitrile--0.01 mol.L-1 sodium phosphate monobasic--N, N, N', N'-tetramethylenediamine (46:54:0.22 v/v, pH 6.9) and the ultraviolet absorbance was monitored at 263 nm. Triazolan was used as internal standard. The calibration curves were linear in the range of 6-480 ng.ml-1 in serum and 0.06-3 micrograms.ml-1 in urine, with mean recoveries of 75.46% and 91.38% respectively. The lowest detectable limits were 4 ng.ml-1 in serum and 40 ng.ml-1 in urine and the RSD for the intra-day and inter-day were less than 5%. A single oral dose of 80 mg sinomenine HCl tablet was given to 8 healthy male volunteers. The concentrations of sinomenine HCl in serum and urine were determined. The serum concentration--time curve was found to fit a two-compartment open model with first order elimination. THE PHARMACOKINETIC PARAMETERS WERE: T1/2 alpha 0.791 +/- 0.491 h, T1/2 beta 9.397 +/- 2.425 h, Tmax 1.040 +/- 0.274 h, Cmax 246.604 +/- 71.165 ng.ml-1, AUC 2651.158 +/- 1039.050 ng.h.ml-1, CL 0.033 +/- 0.010 ng.ml-1.
PMID: 11596314
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