char = W;code = 87 char = o;code = 111 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = t;code = 116 char = i;code = 105 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = e;code = 101 char = :;code = 58 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = m;code = 109 char = ;code = 32 char = h;code = 104 char = e;code = 101 char = m;code = 109 char = o;code = 111 char = d;code = 100 char = y;code = 121 char = n;code = 110 char = a;code = 97 char = m;code = 109 char = i;code = 105 char = c;code = 99 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = u;code = 117 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = l;code = 108 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = z;code = 122 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = 4;code = 52 char = ,;code = 44 char = 3;code = 51 char = 0;code = 48 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = (;code = 40 char = 1;code = 49 char = );code = 41 char = -;code = 45 char = a;code = 97 char = d;code = 100 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = r;code = 114 char = g;code = 103 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = c;code = 99 char = k;code = 107 char = a;code = 97 char = d;code = 100 char = e;code = 101 char = .;code = 46 result sql = Women at altitude: forearm hemodynamics during acclimatization to 4,300 m with alpha(1)-adrenergic blockade.
Women at altitude: forearm hemodynamics during acclimatization to 4,300 m with alpha(1)-adrenergic blockade.char = W;code = 87 char = e;code = 101 char = ;code = 32 char = h;code = 104 char = y;code = 121 char = p;code = 112 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = s;code = 115 char = i;code = 105 char = z;code = 122 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = c;code = 99 char = k;code = 107 char = a;code = 97 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = (;code = 40 char = 1;code = 49 char = );code = 41 char = -;code = 45 char = a;code = 97 char = d;code = 100 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = r;code = 114 char = g;code = 103 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = p;code = 112 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = o;code = 111 char = u;code = 117 char = l;code = 108 char = d;code = 100 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = i;code = 105 char = s;code = 115 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = p;code = 112 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = s;code = 115 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = r;code = 114 char = m;code = 109 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = c;code = 99 char = c;code = 99 char = u;code = 117 char = r;code = 114 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = u;code = 117 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = l;code = 108 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = z;code = 122 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = .;code = 46 char = ;code = 32 char = S;code = 83 char = i;code = 105 char = x;code = 120 char = t;code = 116 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = e;code = 101 char = u;code = 117 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = o;code = 111 char = r;code = 114 char = r;code = 114 char = h;code = 104 char = e;code = 101 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = w;code = 119 char = o;code = 111 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = i;code = 105 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = a;code = 97 char = ;code = 32 char = l;code = 108 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = l;code = 108 char = ;code = 32 char = (;code = 40 char = S;code = 83 char = L;code = 76 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = 4;code = 52 char = ,;code = 44 char = 3;code = 51 char = 0;code = 48 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = ;code = 32 char = (;code = 40 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = s;code = 115 char = ;code = 32 char = 3;code = 51 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = );code = 41 char = .;code = 46 char = ;code = 32 char = V;code = 86 char = o;code = 111 char = l;code = 108 char = u;code = 117 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = o;code = 111 char = m;code = 109 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = t;code = 116 char = a;code = 97 char = k;code = 107 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = l;code = 108 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = (;code = 40 char = 1;code = 49 char = );code = 41 char = -;code = 45 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = c;code = 99 char = k;code = 107 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = c;code = 99 char = e;code = 101 char = b;code = 98 char = o;code = 111 char = .;code = 46 char = ;code = 32 char = V;code = 86 char = e;code = 101 char = n;code = 110 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = l;code = 108 char = i;code = 105 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = m;code = 109 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = s;code = 115 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = o;code = 111 char = d;code = 100 char = ;code = 32 char = f;code = 102 char = l;code = 108 char = o;code = 111 char = w;code = 119 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = u;code = 117 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = e;code = 101 char = t;code = 116 char = h;code = 104 char = y;code = 121 char = s;code = 115 char = m;code = 109 char = o;code = 111 char = g;code = 103 char = r;code = 114 char = a;code = 97 char = p;code = 112 char = h;code = 104 char = y;code = 121 char = .;code = 46 char = ;code = 32 char = V;code = 86 char = e;code = 101 char = n;code = 110 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = l;code = 108 char = i;code = 105 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = f;code = 102 char = e;code = 101 char = l;code = 108 char = l;code = 108 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = 3;code = 51 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = b;code = 98 char = j;code = 106 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = .;code = 46 char = 3;code = 51 char = 9;code = 57 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 3;code = 51 char = 0;code = 48 char = ;code = 32 char = v;code = 118 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = 1;code = 49 char = .;code = 46 char = 6;code = 54 char = 2;code = 50 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 4;code = 52 char = 3;code = 51 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = .;code = 46 char = ;code = 32 char = D;code = 68 char = e;code = 101 char = l;code = 108 char = t;code = 116 char = a;code = 97 char = ;code = 32 char = 3;code = 51 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = m;code = 109 char = H;code = 72 char = g;code = 103 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = ;code = 32 char = t;code = 116 char = i;code = 105 char = s;code = 115 char = s;code = 115 char = u;code = 117 char = e;code = 101 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = S;code = 83 char = L;code = 76 char = ,;code = 44 char = ;code = 32 char = m;code = 109 char = e;code = 101 char = a;code = 97 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = S;code = 83 char = D;code = 68 char = );code = 41 char = .;code = 46 char = ;code = 32 char = A;code = 65 char = l;code = 108 char = t;code = 116 char = i;code = 105 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = (;code = 40 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 0;code = 48 char = 0;code = 48 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = c;code = 99 char = h;code = 104 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = l;code = 108 char = i;code = 105 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = u;code = 117 char = r;code = 114 char = n;code = 110 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = S;code = 83 char = L;code = 76 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = l;code = 108 char = u;code = 117 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = .;code = 46 char = 6;code = 54 char = 8;code = 56 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 1;code = 49 char = 9;code = 57 char = );code = 41 char = ;code = 32 char = b;code = 98 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = c;code = 99 char = e;code = 101 char = b;code = 98 char = o;code = 111 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = .;code = 46 char = 2;code = 50 char = 0;code = 48 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 1;code = 49 char = 0;code = 48 char = ,;code = 44 char = ;code = 32 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = );code = 41 char = .;code = 46 char = ;code = 32 char = B;code = 66 char = y;code = 121 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = 3;code = 51 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = 4;code = 52 char = ,;code = 44 char = 3;code = 51 char = 0;code = 48 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = ;code = 32 char = w;code = 119 char = o;code = 111 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = h;code = 104 char = a;code = 97 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = i;code = 105 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = f;code = 102 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = 3;code = 51 char = 5;code = 53 char = .;code = 46 char = 2;code = 50 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 1;code = 49 char = 3;code = 51 char = .;code = 46 char = 2;code = 50 char = ;code = 32 char = v;code = 118 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = 5;code = 53 char = 4;code = 52 char = .;code = 46 char = 5;code = 53 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 1;code = 49 char = 6;code = 54 char = .;code = 46 char = 1;code = 49 char = ;code = 32 char = m;code = 109 char = m;code = 109 char = H;code = 72 char = g;code = 103 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = S;code = 83 char = L;code = 76 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = r;code = 114 char = i;code = 105 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = o;code = 111 char = d;code = 100 char = ;code = 32 char = f;code = 102 char = l;code = 108 char = o;code = 111 char = w;code = 119 char = ;code = 32 char = (;code = 40 char = 2;code = 50 char = .;code = 46 char = 5;code = 53 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 1;code = 49 char = .;code = 46 char = 0;code = 48 char = ;code = 32 char = v;code = 118 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = 1;code = 49 char = .;code = 46 char = 6;code = 54 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 5;code = 53 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = .;code = 46 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = ;code = 32 char = t;code = 116 char = i;code = 105 char = s;code = 115 char = s;code = 115 char = u;code = 117 char = e;code = 101 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = S;code = 83 char = L;code = 76 char = );code = 41 char = .;code = 46 char = ;code = 32 char = B;code = 66 char = y;code = 121 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = ,;code = 44 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = f;code = 102 char = l;code = 108 char = o;code = 111 char = w;code = 119 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = u;code = 117 char = r;code = 114 char = n;code = 110 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = w;code = 119 char = a;code = 97 char = r;code = 114 char = d;code = 100 char = ;code = 32 char = S;code = 83 char = L;code = 76 char = ,;code = 44 char = ;code = 32 char = b;code = 98 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = u;code = 117 char = r;code = 114 char = n;code = 110 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = l;code = 108 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = (;code = 40 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = :;code = 58 char = ;code = 32 char = 3;code = 51 char = 9;code = 57 char = .;code = 46 char = 8;code = 56 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 4;code = 52 char = .;code = 46 char = 6;code = 54 char = ;code = 32 char = m;code = 109 char = m;code = 109 char = H;code = 72 char = g;code = 103 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = v;code = 118 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = 5;code = 53 char = 8;code = 56 char = .;code = 46 char = 5;code = 53 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 9;code = 57 char = .;code = 46 char = 8;code = 56 char = ;code = 32 char = m;code = 109 char = m;code = 109 char = H;code = 72 char = g;code = 103 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = c;code = 99 char = e;code = 101 char = b;code = 98 char = o;code = 111 char = ;;code = 59 char = ;code = 32 char = f;code = 102 char = l;code = 108 char = o;code = 111 char = w;code = 119 char = :;code = 58 char = ;code = 32 char = 1;code = 49 char = .;code = 46 char = 9;code = 57 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 7;code = 55 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = .;code = 46 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = ;code = 32 char = t;code = 116 char = i;code = 105 char = s;code = 115 char = s;code = 115 char = u;code = 117 char = e;code = 101 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = v;code = 118 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = 2;code = 50 char = .;code = 46 char = 3;code = 51 char = ;code = 32 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 3;code = 51 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = l;code = 108 char = ;code = 32 char = t;code = 116 char = i;code = 105 char = s;code = 115 char = s;code = 115 char = u;code = 117 char = e;code = 101 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = x;code = 120 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = c;code = 99 char = e;code = 101 char = b;code = 98 char = o;code = 111 char = ,;code = 44 char = ;code = 32 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = );code = 41 char = .;code = 46 char = ;code = 32 char = L;code = 76 char = o;code = 111 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = g;code = 103 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = c;code = 99 char = i;code = 105 char = r;code = 114 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = p;code = 112 char = h;code = 104 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = b;code = 98 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = r;code = 114 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = -;code = 45 char = 0;code = 48 char = .;code = 46 char = 5;code = 53 char = 0;code = 48 char = ,;code = 44 char = ;code = 32 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 0;code = 48 char = 0;code = 48 char = 1;code = 49 char = );code = 41 char = .;code = 46 char = ;code = 32 char = H;code = 72 char = i;code = 105 char = g;code = 103 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = c;code = 99 char = i;code = 105 char = r;code = 114 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = r;code = 114 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = p;code = 112 char = h;code = 104 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = l;code = 108 char = o;code = 111 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = l;code = 108 char = i;code = 105 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = l;code = 108 char = a;code = 97 char = c;code = 99 char = e;code = 101 char = b;code = 98 char = o;code = 111 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = (;code = 40 char = r;code = 114 char = ;code = 32 char = =;code = 61 char = ;code = 32 char = -;code = 45 char = 0;code = 48 char = .;code = 46 char = 4;code = 52 char = 2;code = 50 char = ,;code = 44 char = ;code = 32 char = P;code = 80 char = ;code = 32 char = <;code = 60 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = );code = 41 char = .;code = 46 char = ;code = 32 char = W;code = 87 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = c;code = 99 char = l;code = 108 char = u;code = 117 char = d;code = 100 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = p;code = 112 char = h;code = 104 char = a;code = 97 char = (;code = 40 char = 1;code = 49 char = );code = 41 char = -;code = 45 char = a;code = 97 char = d;code = 100 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = r;code = 114 char = g;code = 103 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = m;code = 109 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = d;code = 100 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = p;code = 112 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = s;code = 115 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = a;code = 97 char = n;code = 110 char = g;code = 103 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = u;code = 117 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = c;code = 99 char = l;code = 108 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = z;code = 122 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 result sql = We hypothesized that blockade of alpha(1)-adrenergic receptors would prevent the rise in peripheral vascular resistance that normally occurs during acclimatization. Sixteen eumenorrheic women were studied at sea level (SL) and at 4,300 m (days 3 and 10). Volunteers were randomly assigned to take the selective alpha(1)-blocker prazosin or placebo. Venous compliance, forearm vascular resistance, and blood flow were measured using plethysmography. Venous compliance fell by day 3 in all subjects (1.39 +/- 0.30 vs. 1.62 +/- 0.43 ml. Delta 30 mmHg(-1) x 100 ml tissue(-1) x min(-1) at SL, means +/- SD). Altitude interacted with prazosin treatment (P < 0.0001) such that compliance returned to SL values by day 10 in the prazosin-treated group (1.68 +/- 0.19) but not in the placebo-treated group (1.20 +/- 0.10, P < 0.05). By day 3 at 4,300 m, all women had significant falls in resistance (35.2 +/- 13.2 vs. 54.5 +/- 16.1 mmHg x ml(-1) x min(-1) at SL) and rises in blood flow (2.5 +/- 1.0 vs. 1.6 +/- 0.5 ml. 100 ml tissue(-1) x min(-1) at SL). By day 10, resistance and flow returned toward SL, but this return was less in the prazosin-treated group (resistance: 39.8 +/- 4.6 mmHg x ml(-1) x min(-1) with prazosin vs. 58.5 +/- 9.8 mmHg x ml(-1) x min(-1) with placebo; flow: 1.9 +/- 0.7 ml. 100 ml tissue(-1) x min(-1) with prazosin vs. 2.3 +/- 0.3 ml x 100 ml tissue(-1) x min(-1) with placebo, P < 0.05). Lower resistance related to higher circulating epinephrine in both groups (r = -0.50, P < 0.0001). Higher circulating norepinephrine related to lower venous compliance in the placebo-treated group (r = -0.42, P < 0.05). We conclude that alpha(1)-adrenergic stimulation modulates peripheral vascular changes during acclimatization.
Publication: Am. J. Physiol. Heart Circ. Physiol. 2001 Dec ;281(6)::H2636-44.
Publication Date: 2001 Dec
Study Author(s): Zamudio, S;Douglas, M;Mazzeo, R S;Wolfel, E E;Young, D A;Rock, P B;Braun, B;Muza, S R;Butterfield, G E;Moore, L G;
Institution: Women's Health Research Center, University of Colorado Health Sciences Center, Denver, 80262, USA.
[email protected]
Shortcut link to this study:
We hypothesized that blockade of alpha(1)-adrenergic receptors would prevent the rise in peripheral vascular resistance that normally occurs during acclimatization. Sixteen eumenorrheic women were studied at sea level (SL) and at 4,300 m (days 3 and 10). Volunteers were randomly assigned to take the selective alpha(1)-blocker prazosin or placebo. Venous compliance, forearm vascular resistance, and blood flow were measured using plethysmography. Venous compliance fell by day 3 in all subjects (1.39 +/- 0.30 vs. 1.62 +/- 0.43 ml. Delta 30 mmHg(-1) x 100 ml tissue(-1) x min(-1) at SL, means +/- SD). Altitude interacted with prazosin treatment (P < 0.0001) such that compliance returned to SL values by day 10 in the prazosin-treated group (1.68 +/- 0.19) but not in the placebo-treated group (1.20 +/- 0.10, P < 0.05). By day 3 at 4,300 m, all women had significant falls in resistance (35.2 +/- 13.2 vs. 54.5 +/- 16.1 mmHg x ml(-1) x min(-1) at SL) and rises in blood flow (2.5 +/- 1.0 vs. 1.6 +/- 0.5 ml. 100 ml tissue(-1) x min(-1) at SL). By day 10, resistance and flow returned toward SL, but this return was less in the prazosin-treated group (resistance: 39.8 +/- 4.6 mmHg x ml(-1) x min(-1) with prazosin vs. 58.5 +/- 9.8 mmHg x ml(-1) x min(-1) with placebo; flow: 1.9 +/- 0.7 ml. 100 ml tissue(-1) x min(-1) with prazosin vs. 2.3 +/- 0.3 ml x 100 ml tissue(-1) x min(-1) with placebo, P < 0.05). Lower resistance related to higher circulating epinephrine in both groups (r = -0.50, P < 0.0001). Higher circulating norepinephrine related to lower venous compliance in the placebo-treated group (r = -0.42, P < 0.05). We conclude that alpha(1)-adrenergic stimulation modulates peripheral vascular changes during acclimatization.
PMID: 11709433