char = C;code = 67
Corticosteroid-responsive diabetes mellitus associated with autoimmune pancreatitis: pathological examinations of the endocrine and exocrine pancreas.char = H;code = 72
Publication: Ann. N. Y. Acad. Sci. 2002 Apr ;958:152-9.
Publication Date: 2002 Apr
Study Author(s): Tanaka, Shoichiro;Kobayashi, Tetsuro;Nakanishi, Koji;Okubo, Minoru;Odawara, Masato;Murase, Toshio;Hashimoto, Masaji;Watanabe, Goro;Matsushita, Hiroshi;Inoko, Hidetoshi;Takeuchi, Kazuo;
Institution: Department of Endocrinology and Metabolism, Toranomon Hospital, Tokyo 105-8470, Japan.
[email protected]
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Histopathological changes of biopsied pancreata were examined in three diabetic patients with autoimmune chronic pancreatitis (ACP). We found intra- and periinsular mononuclear cell (MNC)-mainly CD8+ T cell-infiltration as well as MNC infiltration around the ductal cells. Islet beta cell volume decreased significantly. Some ductal cells expressed insulin and insulin promoter factor-1 concomitantly in the affected pancreas. These findings provide new insight toward understanding the pathological mechanisms of corticosteroid treatment-responsive diabetes associated with ACP.
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