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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = t;code = 116
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char = e;code = 101
char = ;code = 32
char = r;code = 114
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char = ;code = 32
char = c;code = 99
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char = o;code = 111
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char = r;code = 114
char = y;code = 121
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char = a;code = 97
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
char = h;code = 104
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char = H;code = 72
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char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ?;code = 63
result sql = Do protease inhibitors increase the risk for coronary heart disease in patients with HIV-1 infection?
Do protease inhibitors increase the risk for coronary heart disease in patients with HIV-1 infection?
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char = ;code = 32
char = c;code = 99
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char = i;code = 105
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char = ;code = 32
char = (;code = 40
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char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = (;code = 40
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char = H;code = 72
char = D;code = 68
char = );code = 41
char = ;code = 32
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char = .;code = 46
char = ;code = 32
char = T;code = 84
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char = s;code = 115
char = ;code = 32
char = o;code = 111
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char = g;code = 103
char = ;code = 32
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char = K;code = 75
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char = e;code = 101
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char = M;code = 77
char = e;code = 101
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char = C;code = 67
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char = r;code = 114
char = a;code = 97
char = m;code = 109
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char = f;code = 102
char = ;code = 32
char = N;code = 78
char = o;code = 111
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = n;code = 110
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char = a;code = 97
char = l;code = 108
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char = f;code = 102
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char = ;code = 32
char = a;code = 97
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char = P;code = 80
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char = ;code = 32
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char = d;code = 100
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char = a;code = 97
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char = e;code = 101
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char = r;code = 114
char = a;code = 97
char = l;code = 108
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char = t;code = 116
char = h;code = 104
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char = r;code = 114
char = a;code = 97
char = p;code = 112
char = y;code = 121
char = ;code = 32
char = (;code = 40
char = A;code = 65
char = R;code = 82
char = T;code = 84
char = );code = 41
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = l;code = 108
char = s;code = 115
char = o;code = 111
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char = ;code = 32
char = C;code = 67
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char = D;code = 68
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char = m;code = 109
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char = I;code = 73
char = ;code = 32
char = r;code = 114
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char = k;code = 107
char = ;code = 32
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result sql = There is continued concern about protease inhibitors (PIs) causing increased risk of coronary heart disease (CHD) in HIV-infected patients. This ongoing observational study examines CHD and myocardial infarction (MI) hospitalization rates among HIV-positive members of the Kaiser Permanente Medical Care Program of Northern California, before and after PI use, and before and after any antiretroviral therapy (ART). Also, CHD and MI hospitalization rates among HIV-infected members are compared with members not known to be HIV-positive. With 4.1 years' median total follow-up, age-adjusted CHD and MI hospitalization rates were not significantly different before versus after PIs (6.2 vs. 6.7 events per 1000 person-years); or before versus after ART (5.7 vs. 6.8). However, comparing HIV-positive and -negative members, the CHD hospitalization rate was significantly higher (6.5 vs. 3.8, p =.003), and the difference in the MI rate also was higher (4.3 vs. 2.9, p =.07). Differences between HIV-positive and -negative members in the CHD risk factors measured were mixed, and the overall clinical significance of these differences is uncertain. Our data suggest that PIs and other antiretroviral therapies do not yet increase CHD or MI hospitalizations among HIV-infected individuals; however, longer follow-up is needed. Other HIV-related mechanisms may be at work, causing increased CHD and MI risk among all HIV-infected persons.

Publication: J. Acquir. Immune Defic. Syndr. 2002 Aug 15 ;30(5)::471-7.
Publication Date: 2002 Aug 15
Study Author(s): Klein, Daniel;Hurley, Leo B;Quesenberry, Charles P;Sidney, Stephen;
Institution: Kaiser Permanente Medical Center, Hayward, California, USA. [email protected]
Shortcut link to this study:
There is continued concern about protease inhibitors (PIs) causing increased risk of coronary heart disease (CHD) in HIV-infected patients. This ongoing observational study examines CHD and myocardial infarction (MI) hospitalization rates among HIV-positive members of the Kaiser Permanente Medical Care Program of Northern California, before and after PI use, and before and after any antiretroviral therapy (ART). Also, CHD and MI hospitalization rates among HIV-infected members are compared with members not known to be HIV-positive. With 4.1 years' median total follow-up, age-adjusted CHD and MI hospitalization rates were not significantly different before versus after PIs (6.2 vs. 6.7 events per 1000 person-years); or before versus after ART (5.7 vs. 6.8). However, comparing HIV-positive and -negative members, the CHD hospitalization rate was significantly higher (6.5 vs. 3.8, p =.003), and the difference in the MI rate also was higher (4.3 vs. 2.9, p =.07). Differences between HIV-positive and -negative members in the CHD risk factors measured were mixed, and the overall clinical significance of these differences is uncertain. Our data suggest that PIs and other antiretroviral therapies do not yet increase CHD or MI hospitalizations among HIV-infected individuals; however, longer follow-up is needed. Other HIV-related mechanisms may be at work, causing increased CHD and MI risk among all HIV-infected persons.
PMID: 12154337

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