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result sql = Correlation between pharmacological effects and plasma cocaine concentrations after smoked administration.
Correlation between pharmacological effects and plasma cocaine concentrations after smoked administration.
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char = t;code = 116
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char = n;code = 110
char = i;code = 105
char = t;code = 116
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char = e;code = 101
char = s;code = 115
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char = o;code = 111
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char = m;code = 109
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = ;code = 32
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char = i;code = 105
char = n;code = 110
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char = r;code = 114
char = ;code = 32
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char = r;code = 114
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char = t;code = 116
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char = n;code = 110
char = e;code = 101
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char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = w;code = 119
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char = e;code = 101
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = a;code = 97
char = n;code = 110
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char = p;code = 112
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = m;code = 109
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
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char = n;code = 110
char = t;code = 116
char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = a;code = 97
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char = a;code = 97
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char = i;code = 105
char = c;code = 99
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char = l;code = 108
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char = f;code = 102
char = e;code = 101
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char = t;code = 116
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char = ;code = 32
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char = e;code = 101
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char = a;code = 97
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = d;code = 100
char = ;code = 32
char = o;code = 111
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char = ;code = 32
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char = ;code = 32
char = h;code = 104
char = ;code = 32
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char = f;code = 102
char = t;code = 116
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char = r;code = 114
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char = o;code = 111
char = s;code = 115
char = i;code = 105
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char = ;code = 32
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char = v;code = 118
char = e;code = 101
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char = ;code = 32
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char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = v;code = 118
char = e;code = 101
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char = d;code = 100
char = ;code = 32
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char = r;code = 114
char = d;code = 100
char = i;code = 105
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char = v;code = 118
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char = c;code = 99
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char = l;code = 108
char = a;code = 97
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char = r;code = 114
char = e;code = 101
char = s;code = 115
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char = e;code = 101
char = t;code = 116
char = u;code = 117
char = r;code = 114
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = a;code = 97
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char = e;code = 101
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = i;code = 105
char = n;code = 110
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result sql = The relationship between blood cocaine concentrations and pharmacological effects is of both theoretical and practical interest. This study utilized a computer-assisted smoking device for the delivery of three active doses (10, 20, and 40 mg) of cocaine base to seven human volunteers. Doses were administered in an ascending dose design with random placement of placebo. Physiological, subjective, and performance measures were collected concurrently with blood samples. Mean peak plasma cocaine concentrations were achieved at 2 min after the 20-mg and 40-mg doses and at 5 min after the 10-mg dose. Maximal responses in systolic and diastolic blood pressure, "feel", "good" drug, and drug "liking" subjective effects were also achieved immediately after drug administration. Pupil diameter and heart rate increases demonstrated a modest counter-clockwise hysteresis in relation to plasma cocaine concentrations shortly after dosing. Systolic and diastolic blood pressure, heart rate, and some subjective and performance measures of drug effect demonstrated a biphasic response after smoked cocaine. Initial increases above baseline levels were followed by an apparent compensatory decrease below baseline levels at a later time after smoked cocaine. Despite evidence of hysteresis and biphasic responses for some measures, linear correlation was obtained between mean plasma cocaine concentrations and several pharmacological effects over a period of 4 h after dosing. Several subjective and cardiovascular measures returned to baseline levels in the presence of detectable concentrations of cocaine.

Publication: J Anal Toxicol 2002 Oct ;26(7)::382-92.
Publication Date: 2002 Oct
Study Author(s): Jenkins, Amanda J;Keenan, Robert M;Henningfield, Jack E;Cone, Edward J;
Institution: Addiction Research Center, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA. [email protected]
Shortcut link to this study:
The relationship between blood cocaine concentrations and pharmacological effects is of both theoretical and practical interest. This study utilized a computer-assisted smoking device for the delivery of three active doses (10, 20, and 40 mg) of cocaine base to seven human volunteers. Doses were administered in an ascending dose design with random placement of placebo. Physiological, subjective, and performance measures were collected concurrently with blood samples. Mean peak plasma cocaine concentrations were achieved at 2 min after the 20-mg and 40-mg doses and at 5 min after the 10-mg dose. Maximal responses in systolic and diastolic blood pressure, "feel", "good" drug, and drug "liking" subjective effects were also achieved immediately after drug administration. Pupil diameter and heart rate increases demonstrated a modest counter-clockwise hysteresis in relation to plasma cocaine concentrations shortly after dosing. Systolic and diastolic blood pressure, heart rate, and some subjective and performance measures of drug effect demonstrated a biphasic response after smoked cocaine. Initial increases above baseline levels were followed by an apparent compensatory decrease below baseline levels at a later time after smoked cocaine. Despite evidence of hysteresis and biphasic responses for some measures, linear correlation was obtained between mean plasma cocaine concentrations and several pharmacological effects over a period of 4 h after dosing. Several subjective and cardiovascular measures returned to baseline levels in the presence of detectable concentrations of cocaine.
PMID: 12422990

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