|
|
char = D;code = 68
char = i;code = 105
char = e;code = 101
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char = r;code = 114
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char = t;code = 116
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char = l;code = 108
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char = p;code = 112
char = p;code = 112
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char = s;code = 115
char = e;code = 101
char = s;code = 115
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char = B;code = 66
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char = s;code = 115
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = j;code = 106
char = u;code = 117
char = r;code = 114
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char = n;code = 110
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = i;code = 105
char = r;code = 114
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = m;code = 109
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char = c;code = 99
char = e;code = 101
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char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = s;code = 115
char = .;code = 46
result sql = Dietary, but not topical, alpha-linolenic acid suppresses UVB-induced skin injury in hairless mice when compared with linoleic acids.
Dietary, but not topical, alpha-linolenic acid suppresses UVB-induced skin injury in hairless mice when compared with linoleic acids.char = P;code = 80
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char = r;code = 114
char = o;code = 111
char = x;code = 120
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char = d;code = 100
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char = z;code = 122
char = a;code = 97
char = b;code = 98
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char = l;code = 108
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
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char = a;code = 97
char = c;code = 99
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char = d;code = 100
char = s;code = 115
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char = i;code = 105
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
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char = r;code = 114
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
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char = g;code = 103
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char = p;code = 112
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char = m;code = 109
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char = f;code = 102
char = ;code = 32
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char = ;code = 32
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char = i;code = 105
char = v;code = 118
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char = ;code = 32
char = c;code = 99
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char = p;code = 112
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char = x;code = 120
char = ;code = 32
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char = a;code = 97
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char = n;code = 110
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char = .;code = 46
char = ;code = 32
char = H;code = 72
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = t;code = 116
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = );code = 41
char = ;code = 32
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char = U;code = 85
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = j;code = 106
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char = r;code = 114
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char = ;code = 32
char = i;code = 105
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char = ;code = 32
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char = ;code = 32
char = s;code = 115
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char = r;code = 114
char = a;code = 97
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char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
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char = i;code = 105
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char = e;code = 101
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char = s;code = 115
char = ;code = 32
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char = c;code = 99
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = U;code = 85
char = V;code = 86
char = B;code = 66
char = -;code = 45
char = i;code = 105
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char = u;code = 117
char = c;code = 99
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char = d;code = 100
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char = e;code = 101
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char = h;code = 104
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char = m;code = 109
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char = s;code = 115
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char = i;code = 105
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char = L;code = 76
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result sql = Peroxidizability of fatty acids in the air is roughly proportional to the number of double bonds, but in vivo peroxidation proceeds in a more complex manner. Here, we compared the effects of dietary and topically applied oils enriched with linoleic acid (LA, 18:2n-6) or alpha-linolenic acid (ALA, 18:3n-3) on UV-induced skin injury in a strain of hairless mice. The UVB-induced erythema score was significantly lower in mice with topically applied creams containing LA and ALA than in mice with the basal cream; no significant increase in the score was detected in the ALA group compared with the LA group. However, dietary ALA inhibited the increase in erythema score after UVB irradiation compared with LA. The peroxidizability index of the skin total lipids was significantly higher, but UVB-induced prostaglandin E2 (PGE2) production was significantly lower in the group fed an ALA-rich diet compared with the group fed an LA-rich diet. The levels of thiobarbituric acid-reactive substances, estimated in the presence of butylated hydroxytoluene in the assay mixture, were not affected by UVB treatment or by the dietary fatty acids, but the severity of the skin lesion was associated with PGE2 levels. These results indicate that the type of fatty acids, n-6 or n-3, is critical for the suppression of UVB-induced skin lesion when the skin fatty acids are modified by dietary manipulation. Anti-inflammatory activity of dietary flaxseed oil with relatively high ALA and low LA contents was demonstrated in UVB-irradiated hairless mice.
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char = e;code = 101
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = s;code = 115
char = .;code = 46
result sql = Dietary, but not topical, alpha-linolenic acid suppresses UVB-induced skin injury in hairless mice when compared with linoleic acids.
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = d;code = 100
char = i;code = 105
char = z;code = 122
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
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char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = i;code = 105
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = u;code = 117
char = m;code = 109
char = b;code = 98
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = u;code = 117
char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = b;code = 98
char = o;code = 111
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char = d;code = 100
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = b;code = 98
char = u;code = 117
char = t;code = 116
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char = i;code = 105
char = n;code = 110
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char = v;code = 118
char = i;code = 105
char = v;code = 118
char = o;code = 111
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = d;code = 100
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = c;code = 99
char = e;code = 101
char = e;code = 101
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = x;code = 120
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = p;code = 112
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = l;code = 108
char = i;code = 105
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = o;code = 111
char = i;code = 105
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = l;code = 108
char = e;code = 101
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char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = d;code = 100
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char = (;code = 40
char = L;code = 76
char = A;code = 65
char = ,;code = 44
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char = 1;code = 49
char = 8;code = 56
char = :;code = 58
char = 2;code = 50
char = n;code = 110
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char = 6;code = 54
char = );code = 41
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = l;code = 108
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char = o;code = 111
char = l;code = 108
char = e;code = 101
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = (;code = 40
char = A;code = 65
char = L;code = 76
char = A;code = 65
char = ,;code = 44
char = ;code = 32
char = 1;code = 49
char = 8;code = 56
char = :;code = 58
char = 3;code = 51
char = n;code = 110
char = -;code = 45
char = 3;code = 51
char = );code = 41
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = U;code = 85
char = V;code = 86
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = s;code = 115
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = j;code = 106
char = u;code = 117
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = s;code = 115
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char = r;code = 114
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = i;code = 105
char = r;code = 114
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = U;code = 85
char = V;code = 86
char = B;code = 66
char = -;code = 45
char = i;code = 105
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char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = e;code = 101
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char = s;code = 115
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char = a;code = 97
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char = ;code = 32
char = s;code = 115
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char = f;code = 102
char = i;code = 105
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char = l;code = 108
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char = l;code = 108
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = e;code = 101
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char = ;code = 32
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char = p;code = 112
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char = c;code = 99
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char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = L;code = 76
char = A;code = 65
char = ;code = 32
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char = ;code = 32
char = A;code = 65
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char = A;code = 65
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char = t;code = 116
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char = t;code = 116
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char = e;code = 101
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char = b;code = 98
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char = a;code = 97
char = l;code = 108
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char = a;code = 97
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char = h;code = 104
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = L;code = 76
char = A;code = 65
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char = g;code = 103
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char = .;code = 46
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char = H;code = 72
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char = U;code = 85
char = V;code = 86
char = B;code = 66
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char = i;code = 105
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char = h;code = 104
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char = L;code = 76
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char = h;code = 104
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char = ,;code = 44
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char = U;code = 85
char = V;code = 86
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char = E;code = 69
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char = L;code = 76
char = A;code = 65
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char = o;code = 111
char = r;code = 114
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
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char = e;code = 101
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char = i;code = 105
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char = t;code = 116
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
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char = t;code = 116
char = t;code = 116
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char = ;code = 32
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char = c;code = 99
char = i;code = 105
char = d;code = 100
char = s;code = 115
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char = t;code = 116
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char = e;code = 101
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char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = ;code = 32
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char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = t;code = 116
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char = e;code = 101
char = l;code = 108
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char = e;code = 101
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char = u;code = 117
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char = t;code = 116
char = s;code = 115
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char = n;code = 110
char = d;code = 100
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char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
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char = c;code = 99
char = i;code = 105
char = d;code = 100
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char = ,;code = 44
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char = r;code = 114
char = ;code = 32
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char = h;code = 104
char = e;code = 101
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char = s;code = 115
char = u;code = 117
char = p;code = 112
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = U;code = 85
char = V;code = 86
char = B;code = 66
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = s;code = 115
char = k;code = 107
char = i;code = 105
char = n;code = 110
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char = l;code = 108
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char = i;code = 105
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char = h;code = 104
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char = t;code = 116
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char = y;code = 121
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char = ;code = 32
char = a;code = 97
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char = e;code = 101
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char = f;code = 102
char = i;code = 105
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char = e;code = 101
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = m;code = 109
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char = i;code = 105
char = p;code = 112
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = .;code = 46
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char = A;code = 65
char = n;code = 110
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char = i;code = 105
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char = v;code = 118
char = i;code = 105
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char = ;code = 32
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char = y;code = 121
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char = x;code = 120
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char = e;code = 101
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char = l;code = 108
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char = o;code = 111
char = w;code = 119
char = ;code = 32
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char = ;code = 32
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char = o;code = 111
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
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char = e;code = 101
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = U;code = 85
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char = d;code = 100
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char = l;code = 108
char = e;code = 101
char = s;code = 115
char = s;code = 115
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result sql = Peroxidizability of fatty acids in the air is roughly proportional to the number of double bonds, but in vivo peroxidation proceeds in a more complex manner. Here, we compared the effects of dietary and topically applied oils enriched with linoleic acid (LA, 18:2n-6) or alpha-linolenic acid (ALA, 18:3n-3) on UV-induced skin injury in a strain of hairless mice. The UVB-induced erythema score was significantly lower in mice with topically applied creams containing LA and ALA than in mice with the basal cream; no significant increase in the score was detected in the ALA group compared with the LA group. However, dietary ALA inhibited the increase in erythema score after UVB irradiation compared with LA. The peroxidizability index of the skin total lipids was significantly higher, but UVB-induced prostaglandin E2 (PGE2) production was significantly lower in the group fed an ALA-rich diet compared with the group fed an LA-rich diet. The levels of thiobarbituric acid-reactive substances, estimated in the presence of butylated hydroxytoluene in the assay mixture, were not affected by UVB treatment or by the dietary fatty acids, but the severity of the skin lesion was associated with PGE2 levels. These results indicate that the type of fatty acids, n-6 or n-3, is critical for the suppression of UVB-induced skin lesion when the skin fatty acids are modified by dietary manipulation. Anti-inflammatory activity of dietary flaxseed oil with relatively high ALA and low LA contents was demonstrated in UVB-irradiated hairless mice.
Publication: Photochem. Photobiol. 2002 Dec ;76(6)::657-63.
Publication Date: 2002 Dec
Study Author(s): Takemura, Naoya;Takahashi, Kazuhiko;Tanaka, Hiroshi;Ihara, Yuka;Ikemoto, Atsushi;Fujii, Yoichi;Okuyama, Harumi;
Institution: Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuhoku, Nagoya, Japan.
Shortcut link to this study:
Publication Date: 2002 Dec
Study Author(s): Takemura, Naoya;Takahashi, Kazuhiko;Tanaka, Hiroshi;Ihara, Yuka;Ikemoto, Atsushi;Fujii, Yoichi;Okuyama, Harumi;
Institution: Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuhoku, Nagoya, Japan.
Shortcut link to this study:
Peroxidizability of fatty acids in the air is roughly proportional to the number of double bonds, but in vivo peroxidation proceeds in a more complex manner. Here, we compared the effects of dietary and topically applied oils enriched with linoleic acid (LA, 18:2n-6) or alpha-linolenic acid (ALA, 18:3n-3) on UV-induced skin injury in a strain of hairless mice. The UVB-induced erythema score was significantly lower in mice with topically applied creams containing LA and ALA than in mice with the basal cream; no significant increase in the score was detected in the ALA group compared with the LA group. However, dietary ALA inhibited the increase in erythema score after UVB irradiation compared with LA. The peroxidizability index of the skin total lipids was significantly higher, but UVB-induced prostaglandin E2 (PGE2) production was significantly lower in the group fed an ALA-rich diet compared with the group fed an LA-rich diet. The levels of thiobarbituric acid-reactive substances, estimated in the presence of butylated hydroxytoluene in the assay mixture, were not affected by UVB treatment or by the dietary fatty acids, but the severity of the skin lesion was associated with PGE2 levels. These results indicate that the type of fatty acids, n-6 or n-3, is critical for the suppression of UVB-induced skin lesion when the skin fatty acids are modified by dietary manipulation. Anti-inflammatory activity of dietary flaxseed oil with relatively high ALA and low LA contents was demonstrated in UVB-irradiated hairless mice.
PMID: 12511046
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