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char = .;code = 46
result sql = Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients.
Positron emission tomography with 11C-acetate and 18F-FDG in prostate cancer patients.
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char = F;code = 70
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char = P;code = 80
char = E;code = 69
char = T;code = 84
char = .;code = 46
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char = B;code = 66
char = a;code = 97
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char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = r;code = 114
char = e;code = 101
char = s;code = 115
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char = l;code = 108
char = t;code = 116
char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = b;code = 98
char = o;code = 111
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char = h;code = 104
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char = P;code = 80
char = E;code = 69
char = T;code = 84
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char = c;code = 99
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char = s;code = 115
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char = p;code = 112
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char = t;code = 116
char = i;code = 105
char = e;code = 101
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char = t;code = 116
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char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = n;code = 110
char = o;code = 111
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = l;code = 108
char = u;code = 117
char = n;code = 110
char = g;code = 103
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char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = M;code = 77
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char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = 1;code = 49
char = 8;code = 56
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char = F;code = 70
char = -;code = 45
char = F;code = 70
char = D;code = 68
char = G;code = 71
char = ;code = 32
char = u;code = 117
char = p;code = 112
char = t;code = 116
char = a;code = 97
char = k;code = 107
char = e;code = 101
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char = e;code = 101
char = x;code = 120
char = c;code = 99
char = e;code = 101
char = e;code = 101
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 1;code = 49
char = );code = 41
char = C;code = 67
char = -;code = 45
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = m;code = 109
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char = a;code = 97
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = S;code = 83
char = U;code = 85
char = V;code = 86
char = ;code = 32
char = =;code = 61
char = 3;code = 51
char = .;code = 46
char = 2;code = 50
char = ;code = 32
char = v;code = 118
char = s;code = 115
char = ;code = 32
char = 2;code = 50
char = .;code = 46
char = 3;code = 51
char = );code = 41
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = l;code = 108
char = o;code = 111
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = r;code = 114
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char = c;code = 99
char = u;code = 117
char = r;code = 114
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = n;code = 110
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char = r;code = 114
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char = g;code = 103
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char = o;code = 111
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = y;code = 121
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char = p;code = 112
char = h;code = 104
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = d;code = 100
char = e;code = 101
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char = m;code = 109
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 1;code = 49
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char = C;code = 67
char = -;code = 45
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = u;code = 117
char = p;code = 112
char = t;code = 116
char = a;code = 97
char = k;code = 107
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = n;code = 110
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char = S;code = 83
char = U;code = 85
char = V;code = 86
char = s;code = 115
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char = =;code = 61
char = 2;code = 50
char = .;code = 46
char = 9;code = 57
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = 3;code = 51
char = .;code = 46
char = 8;code = 56
char = ,;code = 44
char = ;code = 32
char = r;code = 114
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char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
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char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = (;code = 40
char = 1;code = 49
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char = F;code = 70
char = -;code = 45
char = F;code = 70
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char = G;code = 71
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char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = ;code = 32
char = S;code = 83
char = U;code = 85
char = V;code = 86
char = s;code = 115
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char = =;code = 61
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char = 1;code = 49
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char = r;code = 114
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char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
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char = .;code = 46
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char = b;code = 98
char = s;code = 115
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char = e;code = 101
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char = s;code = 115
char = e;code = 101
char = r;code = 114
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char = m;code = 109
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char = P;code = 80
char = S;code = 83
char = A;code = 65
char = ;code = 32
char = l;code = 108
char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = b;code = 98
char = o;code = 111
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char = h;code = 104
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 1;code = 49
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char = C;code = 67
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char = a;code = 97
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char = a;code = 97
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char = a;code = 97
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char = 1;code = 49
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char = F;code = 70
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char = G;code = 71
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char = u;code = 117
char = p;code = 112
char = t;code = 116
char = a;code = 97
char = k;code = 107
char = e;code = 101
char = .;code = 46
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char = (;code = 40
char = 1;code = 49
char = 1;code = 49
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char = C;code = 67
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char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = m;code = 109
char = s;code = 115
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char = m;code = 109
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char = r;code = 114
char = e;code = 101
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char = u;code = 117
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char = e;code = 101
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char = u;code = 117
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char = t;code = 116
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char = a;code = 97
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char = (;code = 40
char = 1;code = 49
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char = );code = 41
char = F;code = 70
char = -;code = 45
char = F;code = 70
char = D;code = 68
char = G;code = 71
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char = i;code = 105
char = n;code = 110
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char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = e;code = 101
char = c;code = 99
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char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
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char = o;code = 111
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char = a;code = 97
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char = r;code = 114
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char = c;code = 99
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char = r;code = 114
char = r;code = 114
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char = e;code = 101
char = s;code = 115
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char = a;code = 97
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char = d;code = 100
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char = a;code = 97
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char = l;code = 108
char = y;code = 121
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char = p;code = 112
char = h;code = 104
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char = a;code = 97
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char = t;code = 116
char = a;code = 97
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char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 8;code = 56
char = );code = 41
char = F;code = 70
char = -;code = 45
char = F;code = 70
char = D;code = 68
char = G;code = 71
char = ,;code = 44
char = ;code = 32
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = v;code = 118
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char = r;code = 114
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char = ;code = 32
char = a;code = 97
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char = p;code = 112
char = e;code = 101
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char = s;code = 115
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char = i;code = 105
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char = a;code = 97
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char = a;code = 97
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char = t;code = 116
char = a;code = 97
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char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = m;code = 109
char = a;code = 97
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char = 1;code = 49
char = 1;code = 49
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char = C;code = 67
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char = a;code = 97
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char = e;code = 101
char = t;code = 116
char = a;code = 97
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char = e;code = 101
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char = 1;code = 49
char = 8;code = 56
char = );code = 41
char = F;code = 70
char = -;code = 45
char = F;code = 70
char = D;code = 68
char = G;code = 71
char = ;code = 32
char = P;code = 80
char = E;code = 69
char = T;code = 84
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = o;code = 111
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char = w;code = 119
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char = ;code = 32
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char = e;code = 101
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char = t;code = 116
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char = p;code = 112
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char = s;code = 115
char = t;code = 116
char = a;code = 97
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char = e;code = 101
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char = c;code = 99
char = a;code = 97
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char = a;code = 97
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char = d;code = 100
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char = p;code = 112
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char = r;code = 114
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char = s;code = 115
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = o;code = 111
char = r;code = 114
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char = n;code = 110
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = P;code = 80
char = S;code = 83
char = A;code = 65
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
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result sql = Visualisation of primary prostate cancer, its relapse and its metastases is a clinically relevant problem despite the availability of state-of-the-art methods such as CT, MRI, transrectal ultrasound and fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET). The aim of this study was to evaluate the efficacy of carbon-11 acetate and (18)F-FDG PET in the detection of prostate cancer and its metastases. Twenty-five patients were investigated during the follow-up of primary prostate cancer, suspected relapse or metastatic disease using (11)C-acetate PET; 15 of these patients were additionally investigated using (18)F-FDG PET. Fourteen patients were receiving anti-androgen treatment at the time of the investigation. Lesions were detected in 20/24 (83%) patients using (11)C-acetate PET and in 10/15 (75%) patients using (18)F-FDG PET. Based on the results of both PET scans, one patient was diagnosed with recurrent lung cancer. Median (18)F-FDG uptake exceeded that of (11)C-acetate in distant metastases (SUV =3.2 vs 2.3). However, in local recurrence and in regional lymph node metastases, (11)C-acetate uptake (median SUVs =2.9 and 3.8, respectively) was higher than that of (18)F-FDG (median SUVs =1.0 and 1.1, respectively). A positive correlation was observed between serum PSA level and both (11)C-acetate uptake and (18)F-FDG uptake. (11)C-acetate seems more useful than (18)F-FDG in the detection of local recurrences and regional lymph node metastases. (18)F-FDG, however, appears to be more accurate in visualising distant metastases. There may be a role for combined (11)C-acetate/(18)F-FDG PET in the follow-up of patients with prostate cancer and persisting or increasing PSA.

Publication: Eur. J. Nucl. Med. Mol. Imaging 2003 Apr ;30(4)::607-11.
Publication Date: 2003 Apr
Study Author(s): Fricke, E;Machtens, S;Hofmann, M;van den Hoff, J;Bergh, S;Brunkhorst, T;Meyer, G J;Karstens, J H;Knapp, W H;Boerner, A R;
Institution: Department of Nuclear Medicine, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany. [email protected]
Shortcut link to this study:
Visualisation of primary prostate cancer, its relapse and its metastases is a clinically relevant problem despite the availability of state-of-the-art methods such as CT, MRI, transrectal ultrasound and fluorine-18 fluorodeoxyglucose positron emission tomography ((18)F-FDG PET). The aim of this study was to evaluate the efficacy of carbon-11 acetate and (18)F-FDG PET in the detection of prostate cancer and its metastases. Twenty-five patients were investigated during the follow-up of primary prostate cancer, suspected relapse or metastatic disease using (11)C-acetate PET; 15 of these patients were additionally investigated using (18)F-FDG PET. Fourteen patients were receiving anti-androgen treatment at the time of the investigation. Lesions were detected in 20/24 (83%) patients using (11)C-acetate PET and in 10/15 (75%) patients using (18)F-FDG PET. Based on the results of both PET scans, one patient was diagnosed with recurrent lung cancer. Median (18)F-FDG uptake exceeded that of (11)C-acetate in distant metastases (SUV =3.2 vs 2.3). However, in local recurrence and in regional lymph node metastases, (11)C-acetate uptake (median SUVs =2.9 and 3.8, respectively) was higher than that of (18)F-FDG (median SUVs =1.0 and 1.1, respectively). A positive correlation was observed between serum PSA level and both (11)C-acetate uptake and (18)F-FDG uptake. (11)C-acetate seems more useful than (18)F-FDG in the detection of local recurrences and regional lymph node metastases. (18)F-FDG, however, appears to be more accurate in visualising distant metastases. There may be a role for combined (11)C-acetate/(18)F-FDG PET in the follow-up of patients with prostate cancer and persisting or increasing PSA.
PMID: 12589476

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