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result sql = Involvement of spinal tyrosine kinase in inflammatory and N-methyl-D-aspartate-induced hyperalgesia in rats.
Involvement of spinal tyrosine kinase in inflammatory and N-methyl-D-aspartate-induced hyperalgesia in rats.
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char = c;code = 99
char = a;code = 97
char = l;code = 108
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char = y;code = 121
char = p;code = 112
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char = r;code = 114
char = a;code = 97
char = l;code = 108
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = a;code = 97
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char = ;code = 32
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char = t;code = 116
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char = t;code = 116
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char = i;code = 105
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char = o;code = 111
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char = o;code = 111
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char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
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char = c;code = 99
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char = l;code = 108
char = ;code = 32
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char = l;code = 108
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char = e;code = 101
char = s;code = 115
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char = a;code = 97
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char = o;code = 111
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char = a;code = 97
char = d;code = 100
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char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 0;code = 48
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = ;code = 32
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char = ;code = 32
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char = t;code = 116
char = h;code = 104
char = ;code = 32
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char = M;code = 77
char = D;code = 68
char = A;code = 65
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
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char = l;code = 108
char = y;code = 121
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = u;code = 117
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = o;code = 111
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char = t;code = 116
char = a;code = 97
char = n;code = 110
char = e;code = 101
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = i;code = 105
char = o;code = 111
char = u;code = 117
char = r;code = 114
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = n;code = 110
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char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = N;code = 78
char = M;code = 77
char = D;code = 68
char = A;code = 65
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char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = a;code = 97
char = .;code = 46
char = ;code = 32
char = L;code = 76
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = d;code = 100
char = u;code = 117
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = A;code = 65
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = f;code = 102
char = ;code = 32
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char = d;code = 100
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char = ;code = 32
char = c;code = 99
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char = s;code = 115
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char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = ;code = 32
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
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char = o;code = 111
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char = m;code = 109
char = p;code = 112
char = a;code = 97
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char = r;code = 114
char = m;code = 109
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char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = a;code = 97
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char = ;code = 32
char = O;code = 79
char = u;code = 117
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char = g;code = 103
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char = t;code = 116
char = ;code = 32
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char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = T;code = 84
char = K;code = 75
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = u;code = 117
char = l;code = 108
char = d;code = 100
char = ;code = 32
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char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = l;code = 108
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = N;code = 78
char = M;code = 77
char = D;code = 68
char = A;code = 65
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = -;code = 45
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = <;code = 60
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char = /;code = 47
char = >;code = 62
result sql = Phosphorylation of a subunit of N-methyl-D-aspartate (NMDA) receptor by protein tyrosine kinase (PTK) Src or Trk is known to enhance its channel activity. We examined whether a spinally administered selective PTK inhibitor, lavendustin A, which has high affinity for Src and Trk tyrosine kinases, could influence the development and maintenance of inflammatory hyperalgesia or NMDA-induced hyperalgesia. Inflammation was induced by injection of a mixture of carrageenan and kaolin into the tail base of rats. In another group of rats, hyperalgesia was induced by intrathecal administration of NMDA. Intrathecal administration of lavendustin A (1.0 microg) or NMDA receptor antagonist, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cycloheptane-5,10-iminemaleate, MK-801 (3.0 microg) before injection of a mixture of carrageenan and kaolin or after the development of inflammation inhibited carrageenan-kaolin-induced mechanical hyperalgesia. Intrathecal injection of 1.0 microg NMDA produced thermal and mechanical hyperalgesia. Co-administration of 1.0 microg lavendustin A with NMDA significantly reduced the duration of spontaneous pain behaviour and inhibited NMDA-induced hyperalgesia. Lavendustin A itself did not cause any sedation, motor impairment or analgesia. Our results suggest that inhibition of PTK could be therapeutically effective as an analgesic in some NMDA receptor-mediated hyperalgesic states.

Publication: Eur. J. Pharmacol. 2003 May 16 ;468(3)::191-8.
Publication Date: 2003 May 16
Study Author(s): Sato, Eiru;Takano, Yoshito;Kuno, Yuichiro;Takano, Manami;Sato, Isao;
Institution: Department of Anesthesiology, Koshigaya Hospital, Dokkyo University, School of Medicine, 2-1-50 Minami-Koshigaya, Saitama 343-8555, Koshigaya City, Japan. [email protected]
Shortcut link to this study:
Phosphorylation of a subunit of N-methyl-D-aspartate (NMDA) receptor by protein tyrosine kinase (PTK) Src or Trk is known to enhance its channel activity. We examined whether a spinally administered selective PTK inhibitor, lavendustin A, which has high affinity for Src and Trk tyrosine kinases, could influence the development and maintenance of inflammatory hyperalgesia or NMDA-induced hyperalgesia. Inflammation was induced by injection of a mixture of carrageenan and kaolin into the tail base of rats. In another group of rats, hyperalgesia was induced by intrathecal administration of NMDA. Intrathecal administration of lavendustin A (1.0 microg) or NMDA receptor antagonist, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cycloheptane-5,10-iminemaleate, MK-801 (3.0 microg) before injection of a mixture of carrageenan and kaolin or after the development of inflammation inhibited carrageenan-kaolin-induced mechanical hyperalgesia. Intrathecal injection of 1.0 microg NMDA produced thermal and mechanical hyperalgesia. Co-administration of 1.0 microg lavendustin A with NMDA significantly reduced the duration of spontaneous pain behaviour and inhibited NMDA-induced hyperalgesia. Lavendustin A itself did not cause any sedation, motor impairment or analgesia. Our results suggest that inhibition of PTK could be therapeutically effective as an analgesic in some NMDA receptor-mediated hyperalgesic states.
PMID: 12754057

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