|
|
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result sql = Analysis of human equilibrative nucleoside transporter 1 (hENT1) protein in non-Hodgkin's lymphoma by immunohistochemistry.
Analysis of human equilibrative nucleoside transporter 1 (hENT1) protein in non-Hodgkin's lymphoma by immunohistochemistry.char = T;code = 84
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char = B;code = 66
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char = l;code = 108
char = s;code = 115
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char = d;code = 100
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char = r;code = 114
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char = o;code = 111
char = l;code = 108
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = T;code = 84
char = -;code = 45
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = n;code = 110
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char = a;code = 97
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char = i;code = 105
char = v;code = 118
char = e;code = 101
char = .;code = 46
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char = I;code = 73
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char = N;code = 78
char = H;code = 72
char = L;code = 76
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = r;code = 114
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char = a;code = 97
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char = v;code = 118
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char = l;code = 108
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char = i;code = 105
char = g;code = 103
char = h;code = 104
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char = r;code = 114
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char = q;code = 113
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char = e;code = 101
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char = c;code = 99
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char = o;code = 111
char = f;code = 102
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char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
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char = p;code = 112
char = o;code = 111
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char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = t;code = 116
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char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = n;code = 110
char = d;code = 100
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char = i;code = 105
char = n;code = 110
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char = B;code = 66
char = u;code = 117
char = r;code = 114
char = k;code = 107
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char = t;code = 116
char = t;code = 116
char = ;code = 32
char = l;code = 108
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char = m;code = 109
char = p;code = 112
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char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = l;code = 108
char = e;code = 101
char = u;code = 117
char = k;code = 107
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = a;code = 97
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char = 6;code = 54
char = 3;code = 51
char = %;code = 37
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char = ,;code = 44
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char = d;code = 100
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = u;code = 117
char = s;code = 115
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char = l;code = 108
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
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char = B;code = 66
char = -;code = 45
char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = (;code = 40
char = D;code = 68
char = L;code = 76
char = C;code = 67
char = L;code = 76
char = ;;code = 59
char = ;code = 32
char = 4;code = 52
char = 5;code = 53
char = %;code = 37
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = l;code = 108
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = (;code = 40
char = 4;code = 52
char = 0;code = 48
char = %;code = 37
char = );code = 41
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
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char = D;code = 68
char = L;code = 76
char = C;code = 67
char = L;code = 76
char = ,;code = 44
char = ;code = 32
char = 2;code = 50
char = 6;code = 54
char = %;code = 37
char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = p;code = 112
char = o;code = 111
char = s;code = 115
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char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = C;code = 67
char = D;code = 68
char = 1;code = 49
char = 0;code = 48
char = ,;code = 44
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char = a;code = 97
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char = C;code = 67
char = D;code = 68
char = 1;code = 49
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char = s;code = 115
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char = i;code = 105
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char = e;code = 101
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char = D;code = 68
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char = C;code = 67
char = L;code = 76
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char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = r;code = 114
char = e;code = 101
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char = m;code = 109
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char = e;code = 101
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char = k;code = 107
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char = o;code = 111
char = ;code = 32
char = b;code = 98
char = e;code = 101
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char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
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char = t;code = 116
char = i;code = 105
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = C;code = 67
char = D;code = 68
char = 1;code = 49
char = 0;code = 48
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char = n;code = 110
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char = g;code = 103
char = a;code = 97
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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
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char = P;code = 80
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char = .;code = 46
char = 0;code = 48
char = 2;code = 50
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char = .;code = 46
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char = A;code = 65
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char = e;code = 101
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char = e;code = 101
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char = o;code = 111
char = f;code = 102
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char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
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char = p;code = 112
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char = i;code = 105
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char = a;code = 97
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char = l;code = 108
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char = .;code = 46
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char = A;code = 65
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char = l;code = 108
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char = o;code = 111
char = m;code = 109
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char = o;code = 111
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char = h;code = 104
char = E;code = 69
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char = T;code = 84
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char = w;code = 119
char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
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char = i;code = 105
char = m;code = 109
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char = u;code = 117
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char = t;code = 116
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char = r;code = 114
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char = N;code = 78
char = H;code = 72
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char = r;code = 114
char = e;code = 101
char = ;code = 32
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char = r;code = 114
char = r;code = 114
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result sql = The human equilibrative nucleoside transporter 1 (hENT1) is a member of the equilibrative nucleoside transporter family that mediates cellular entry of gemcitabine, cytarabine, and fludarabine. Deficiency in hENT1 confers resistance to toxicity of these drugs in a variety of model systems. Since some nucleoside analogs have a role in treating patients with non-Hodgkin's lymphoma (NHL), this study was undertaken to assess hENT1 abundance in NHL. A total of 115 cases of NHL of various subtypes and 15 reactive lymph nodes were evaluated for the presence of hENT1 protein using immunohistochemistry applied to frozen tissues. Samples were considered positive when >or=50% of neoplastic cells showed immunostaining. In reactive lymph nodes, hENT1 was confined to the germinal centers, whereas mantle zone B-cells and interfollicular T-cells were negative. In NHL, a relatively high frequency of hENT1 positivity was found in Burkitt lymphoma/leukemia (63%), diffuse large B-cell lymphoma (DLCL; 45%), and follicular lymphoma (40%). In DLCL, 26% of cases were positive for CD10, and CD10-positive DLCL cases were more likely to be hENT1 positive than CD10-negative cases (P=0.025). A lower frequency of hENT1 positivity was found in mantle cell lymphoma (13%) and peripheral T-cell lymphomas (37%). All marginal zone lymphomas (n=5), chronic lymphocytic leukemia small lymphocytic lymphomas (n=10), plasmacytoma (n=3), acute lymphoblastic lymphoma/leukemia, and anaplastic large-cell lymphomas (n=5) were negative. In conclusion, hENT1 was most frequently found in benign and malignant follicular center cells. Prospective studies to assess the value of hENT1 immunostaining in predicting resistance to nucleoside chemotherapy for NHL are warranted.
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = b;code = 98
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = d;code = 100
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char = n;code = 110
char = s;code = 115
char = p;code = 112
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char = ;code = 32
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char = ;code = 32
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char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = n;code = 110
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char = d;code = 100
char = g;code = 103
char = k;code = 107
char = i;code = 105
char = n;code = 110
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char = y;code = 121
char = m;code = 109
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = m;code = 109
char = u;code = 117
char = n;code = 110
char = o;code = 111
char = h;code = 104
char = i;code = 105
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char = t;code = 116
char = o;code = 111
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = y;code = 121
char = .;code = 46
result sql = Analysis of human equilibrative nucleoside transporter 1 (hENT1) protein in non-Hodgkin's lymphoma by immunohistochemistry.
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char = l;code = 108
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char = e;code = 101
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = S;code = 83
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char = e;code = 101
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char = s;code = 115
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char = g;code = 103
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char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = v;code = 118
char = e;code = 101
char = ;code = 32
char = l;code = 108
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char = p;code = 112
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char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = f;code = 102
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = z;code = 122
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = B;code = 66
char = -;code = 45
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = T;code = 84
char = -;code = 45
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = g;code = 103
char = a;code = 97
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char = i;code = 105
char = v;code = 118
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = N;code = 78
char = H;code = 72
char = L;code = 76
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = B;code = 66
char = u;code = 117
char = r;code = 114
char = k;code = 107
char = i;code = 105
char = t;code = 116
char = t;code = 116
char = ;code = 32
char = l;code = 108
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = /;code = 47
char = l;code = 108
char = e;code = 101
char = u;code = 117
char = k;code = 107
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = (;code = 40
char = 6;code = 54
char = 3;code = 51
char = %;code = 37
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = B;code = 66
char = -;code = 45
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = ;code = 32
char = (;code = 40
char = D;code = 68
char = L;code = 76
char = C;code = 67
char = L;code = 76
char = ;;code = 59
char = ;code = 32
char = 4;code = 52
char = 5;code = 53
char = %;code = 37
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = l;code = 108
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = ;code = 32
char = (;code = 40
char = 4;code = 52
char = 0;code = 48
char = %;code = 37
char = );code = 41
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = L;code = 76
char = C;code = 67
char = L;code = 76
char = ,;code = 44
char = ;code = 32
char = 2;code = 50
char = 6;code = 54
char = %;code = 37
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = C;code = 67
char = D;code = 68
char = 1;code = 49
char = 0;code = 48
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = C;code = 67
char = D;code = 68
char = 1;code = 49
char = 0;code = 48
char = -;code = 45
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = D;code = 68
char = L;code = 76
char = C;code = 67
char = L;code = 76
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = m;code = 109
char = o;code = 111
char = r;code = 114
char = e;code = 101
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char = l;code = 108
char = i;code = 105
char = k;code = 107
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
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char = C;code = 67
char = D;code = 68
char = 1;code = 49
char = 0;code = 48
char = -;code = 45
char = n;code = 110
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char = g;code = 103
char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = e;code = 101
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char = c;code = 99
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = P;code = 80
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char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 2;code = 50
char = 5;code = 53
char = );code = 41
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = r;code = 114
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char = f;code = 102
char = r;code = 114
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
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char = m;code = 109
char = a;code = 97
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char = t;code = 116
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char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = l;code = 108
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char = h;code = 104
char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = (;code = 40
char = 1;code = 49
char = 3;code = 51
char = %;code = 37
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = p;code = 112
char = e;code = 101
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char = p;code = 112
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = T;code = 84
char = -;code = 45
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = y;code = 121
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char = p;code = 112
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char = o;code = 111
char = m;code = 109
char = a;code = 97
char = s;code = 115
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char = (;code = 40
char = 3;code = 51
char = 7;code = 55
char = %;code = 37
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = z;code = 122
char = o;code = 111
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char = e;code = 101
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char = l;code = 108
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = m;code = 109
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = n;code = 110
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char = 5;code = 53
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = y;code = 121
char = m;code = 109
char = p;code = 112
char = h;code = 104
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char = y;code = 121
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = e;code = 101
char = u;code = 117
char = k;code = 107
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = a;code = 97
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char = s;code = 115
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = l;code = 108
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char = l;code = 108
char = y;code = 121
char = m;code = 109
char = p;code = 112
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char = o;code = 111
char = c;code = 99
char = y;code = 121
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char = i;code = 105
char = c;code = 99
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char = l;code = 108
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char = p;code = 112
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char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = ,;code = 44
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char = l;code = 108
char = a;code = 97
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char = a;code = 97
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char = g;code = 103
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char = l;code = 108
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char = l;code = 108
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char = p;code = 112
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char = o;code = 111
char = m;code = 109
char = a;code = 97
char = s;code = 115
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char = n;code = 110
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char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = e;code = 101
char = g;code = 103
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
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char = c;code = 99
char = o;code = 111
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char = c;code = 99
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char = u;code = 117
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
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char = m;code = 109
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char = t;code = 116
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char = f;code = 102
char = r;code = 114
char = e;code = 101
char = q;code = 113
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char = e;code = 101
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char = o;code = 111
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char = n;code = 110
char = d;code = 100
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char = i;code = 105
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char = b;code = 98
char = e;code = 101
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char = g;code = 103
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = i;code = 105
char = g;code = 103
char = n;code = 110
char = a;code = 97
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char = f;code = 102
char = o;code = 111
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char = l;code = 108
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char = c;code = 99
char = u;code = 117
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char = a;code = 97
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = P;code = 80
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = s;code = 115
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char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
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char = t;code = 116
char = o;code = 111
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
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char = a;code = 97
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = E;code = 69
char = N;code = 78
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = m;code = 109
char = u;code = 117
char = n;code = 110
char = o;code = 111
char = s;code = 115
char = t;code = 116
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char = g;code = 103
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char = p;code = 112
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = n;code = 110
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = y;code = 121
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = N;code = 78
char = H;code = 72
char = L;code = 76
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = r;code = 114
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char = n;code = 110
char = t;code = 116
char = e;code = 101
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result sql = The human equilibrative nucleoside transporter 1 (hENT1) is a member of the equilibrative nucleoside transporter family that mediates cellular entry of gemcitabine, cytarabine, and fludarabine. Deficiency in hENT1 confers resistance to toxicity of these drugs in a variety of model systems. Since some nucleoside analogs have a role in treating patients with non-Hodgkin's lymphoma (NHL), this study was undertaken to assess hENT1 abundance in NHL. A total of 115 cases of NHL of various subtypes and 15 reactive lymph nodes were evaluated for the presence of hENT1 protein using immunohistochemistry applied to frozen tissues. Samples were considered positive when >or=50% of neoplastic cells showed immunostaining. In reactive lymph nodes, hENT1 was confined to the germinal centers, whereas mantle zone B-cells and interfollicular T-cells were negative. In NHL, a relatively high frequency of hENT1 positivity was found in Burkitt lymphoma/leukemia (63%), diffuse large B-cell lymphoma (DLCL; 45%), and follicular lymphoma (40%). In DLCL, 26% of cases were positive for CD10, and CD10-positive DLCL cases were more likely to be hENT1 positive than CD10-negative cases (P=0.025). A lower frequency of hENT1 positivity was found in mantle cell lymphoma (13%) and peripheral T-cell lymphomas (37%). All marginal zone lymphomas (n=5), chronic lymphocytic leukemia small lymphocytic lymphomas (n=10), plasmacytoma (n=3), acute lymphoblastic lymphoma/leukemia, and anaplastic large-cell lymphomas (n=5) were negative. In conclusion, hENT1 was most frequently found in benign and malignant follicular center cells. Prospective studies to assess the value of hENT1 immunostaining in predicting resistance to nucleoside chemotherapy for NHL are warranted.
Publication: Mod. Pathol. 2005 Apr ;18(4)::558-64.
Publication Date: 2005 Apr
Study Author(s): Chow, Laura;Lai, Raymond;Dabbagh, Laith;Belch, Andrew;Young, James D;Cass, Carol E;Mackey, John R;
Institution: Department of Medical Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.
Shortcut link to this study:
Publication Date: 2005 Apr
Study Author(s): Chow, Laura;Lai, Raymond;Dabbagh, Laith;Belch, Andrew;Young, James D;Cass, Carol E;Mackey, John R;
Institution: Department of Medical Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada.
Shortcut link to this study:
The human equilibrative nucleoside transporter 1 (hENT1) is a member of the equilibrative nucleoside transporter family that mediates cellular entry of gemcitabine, cytarabine, and fludarabine. Deficiency in hENT1 confers resistance to toxicity of these drugs in a variety of model systems. Since some nucleoside analogs have a role in treating patients with non-Hodgkin's lymphoma (NHL), this study was undertaken to assess hENT1 abundance in NHL. A total of 115 cases of NHL of various subtypes and 15 reactive lymph nodes were evaluated for the presence of hENT1 protein using immunohistochemistry applied to frozen tissues. Samples were considered positive when >or=50% of neoplastic cells showed immunostaining. In reactive lymph nodes, hENT1 was confined to the germinal centers, whereas mantle zone B-cells and interfollicular T-cells were negative. In NHL, a relatively high frequency of hENT1 positivity was found in Burkitt lymphoma/leukemia (63%), diffuse large B-cell lymphoma (DLCL; 45%), and follicular lymphoma (40%). In DLCL, 26% of cases were positive for CD10, and CD10-positive DLCL cases were more likely to be hENT1 positive than CD10-negative cases (P=0.025). A lower frequency of hENT1 positivity was found in mantle cell lymphoma (13%) and peripheral T-cell lymphomas (37%). All marginal zone lymphomas (n=5), chronic lymphocytic leukemia small lymphocytic lymphomas (n=10), plasmacytoma (n=3), acute lymphoblastic lymphoma/leukemia, and anaplastic large-cell lymphomas (n=5) were negative. In conclusion, hENT1 was most frequently found in benign and malignant follicular center cells. Prospective studies to assess the value of hENT1 immunostaining in predicting resistance to nucleoside chemotherapy for NHL are warranted.
PMID: 15529184
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