char = P;code = 80
char = o;code = 111
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char = e;code = 101
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = s;code = 115
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = ;code = 32
char = Q;code = 81
char = T;code = 84
char = L;code = 76
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = i;code = 105
char = c;code = 99
char = ,;code = 44
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = g;code = 103
char = r;code = 114
char = e;code = 101
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = r;code = 114
char = k;code = 107
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = b;code = 98
char = r;code = 114
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = m;code = 109
char = .;code = 46
result sql = Power of in silico QTL mapping from phenotypic, pedigree, and marker data in a hybrid breeding program.
Power of in silico QTL mapping from phenotypic, pedigree, and marker data in a hybrid breeding program.
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char = n;code = 110
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char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = t;code = 116
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char = c;code = 99
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char = ;code = 32
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char = a;code = 97
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char = p;code = 112
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char = d;code = 100
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char = p;code = 112
char = p;code = 112
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char = p;code = 112
char = u;code = 117
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = ;code = 32
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char = l;code = 108
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char = e;code = 101
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char = o;code = 111
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char = l;code = 108
char = ;code = 32
char = Q;code = 81
char = T;code = 84
char = L;code = 76
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = p;code = 112
char = p;code = 112
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char = n;code = 110
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char = v;code = 118
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char = ;code = 32
char = a;code = 97
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char = l;code = 108
char = t;code = 116
char = a;code = 97
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char = y;code = 121
char = ;code = 32
char = e;code = 101
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char = l;code = 108
char = o;code = 111
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char = t;code = 116
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = o;code = 111
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char = y;code = 121
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char = i;code = 105
char = c;code = 99
char = ,;code = 44
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = o;code = 111
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char = ;code = 32
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char = g;code = 103
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char = e;code = 101
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char = a;code = 97
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char = a;code = 97
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char = l;code = 108
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = e;code = 101
char = d;code = 100
char = i;code = 105
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char = g;code = 103
char = ;code = 32
char = p;code = 112
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char = o;code = 111
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = m;code = 109
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = s;code = 115
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = l;code = 108
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char = p;code = 112
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char = e;code = 101
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = m;code = 109
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char = t;code = 116
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char = l;code = 108
char = u;code = 117
char = a;code = 97
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char = e;code = 101
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char = p;code = 112
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char = o;code = 111
char = ;code = 32
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char = e;code = 101
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = T;code = 84
char = L;code = 76
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char = a;code = 97
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char = e;code = 101
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char = o;code = 111
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char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = s;code = 115
char = e;code = 101
char = ;code = 32
char = Q;code = 81
char = T;code = 84
char = L;code = 76
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char = w;code = 119
char = o;code = 111
char = u;code = 117
char = l;code = 108
char = d;code = 100
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char = e;code = 101
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char = e;code = 101
char = c;code = 99
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result sql = Most quantitative trait locus (QTL) mapping studies in plants have used designed mapping populations. As an alternative to traditional QTL mapping, in silico mapping via a mixed-model approach simultaneously exploits phenotypic, genotypic, and pedigree data already available in breeding programs. The statistical power of this in silico mapping method, however, remains unknown. Our objective was to evaluate the power of in silico mapping via a mixed-model approach in hybrid crops. We used maize (Zea mays L.) as a model species to study, by computer simulation, the influence of number of QTLs (20 or 80), heritability (0.40 or 0.70), number of markers (200 or 400), and sample size (600 or 2,400 hybrids). We found that the average power to detect QTLs ranged from 0.11 to 0.59 for a significance level of alpha=0.01, and from 0.01 to 0.47 for alpha=0.0001. The false discovery rate ranged from 0.22 to 0.74 for alpha=0.01, and from 0.05 to 0.46 for alpha=0.0001. As with designed mapping experiments, a large sample size, high marker density, high heritability, and small number of QTLs led to the highest power for in silico mapping via a mixed-model approach. The power to detect QTLs with large effects was greater than the power to detect QTL with small effects. We conclude that gene discovery in hybrid crops can be initiated by in silico mapping. Finding an acceptable compromise, however, between the power to detect QTL and the proportion of false QTL would be necessary.

Publication: Theor. Appl. Genet. 2005 Apr ;110(6)::1061-7.
Publication Date: 2005 Apr
Study Author(s): Yu, J;Arbelbide, M;Bernardo, R;
Institution: Department of Agronomy and Plant Genetics, University of Minnesota, 411 Borlaug Hall, 1991 Upper Buford Circle, St. Paul, MN 55108, USA.
Shortcut link to this study:
Most quantitative trait locus (QTL) mapping studies in plants have used designed mapping populations. As an alternative to traditional QTL mapping, in silico mapping via a mixed-model approach simultaneously exploits phenotypic, genotypic, and pedigree data already available in breeding programs. The statistical power of this in silico mapping method, however, remains unknown. Our objective was to evaluate the power of in silico mapping via a mixed-model approach in hybrid crops. We used maize (Zea mays L.) as a model species to study, by computer simulation, the influence of number of QTLs (20 or 80), heritability (0.40 or 0.70), number of markers (200 or 400), and sample size (600 or 2,400 hybrids). We found that the average power to detect QTLs ranged from 0.11 to 0.59 for a significance level of alpha=0.01, and from 0.01 to 0.47 for alpha=0.0001. The false discovery rate ranged from 0.22 to 0.74 for alpha=0.01, and from 0.05 to 0.46 for alpha=0.0001. As with designed mapping experiments, a large sample size, high marker density, high heritability, and small number of QTLs led to the highest power for in silico mapping via a mixed-model approach. The power to detect QTLs with large effects was greater than the power to detect QTL with small effects. We conclude that gene discovery in hybrid crops can be initiated by in silico mapping. Finding an acceptable compromise, however, between the power to detect QTL and the proportion of false QTL would be necessary.
PMID: 15754207

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