|
|
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result sql = The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.
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char = t;code = 116
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char = r;code = 114
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = o;code = 111
char = s;code = 115
char = t;code = 116
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char = o;code = 111
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Human cysteine proteases of the papain family have been recognized as potential drug targets for musculoskeletal diseases. Most of the interest is focused on cathepsins S and K, which display selective expression in cells of the immune system and cells capable to efficiently degrade extracellular matrix proteins, in particular collagens. The predominant expression of cathepsin K in osteoclasts has rendered the enzyme into a major target for the development of novel anti-resorptive drugs in osteoporosis whereas cathepsin S appears to be an attractive drug target candidate for various inflammatory diseases including rheumatoid arthritis. Since rheumatoid arthritis is at the same time an inflammatory and joint destructive disorder, the combined inhibition of both cathepsins S and K should be beneficial. This review will outline the rationale and recent progress for targeting cathepsins in arthritis and osteoporosis.
char = h;code = 104
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = o;code = 111
char = p;code = 112
char = o;code = 111
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char = o;code = 111
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char = i;code = 105
char = s;code = 115
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char = h;code = 104
char = r;code = 114
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char = t;code = 116
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
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char = s;code = 115
char = .;code = 46
result sql = The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics.
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result sql = Human cysteine proteases of the papain family have been recognized as potential drug targets for musculoskeletal diseases. Most of the interest is focused on cathepsins S and K, which display selective expression in cells of the immune system and cells capable to efficiently degrade extracellular matrix proteins, in particular collagens. The predominant expression of cathepsin K in osteoclasts has rendered the enzyme into a major target for the development of novel anti-resorptive drugs in osteoporosis whereas cathepsin S appears to be an attractive drug target candidate for various inflammatory diseases including rheumatoid arthritis. Since rheumatoid arthritis is at the same time an inflammatory and joint destructive disorder, the combined inhibition of both cathepsins S and K should be beneficial. This review will outline the rationale and recent progress for targeting cathepsins in arthritis and osteoporosis.
Publication: Adv. Drug Deliv. Rev. 2005 May 25 ;57(7)::973-93.
Publication Date: 2005 May 25
Study Author(s): Yasuda, Yoshiyuki;Kaleta, Jadwiga;Brömme, Dieter;
Institution: University of British Columbia, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, 2199 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3.
Shortcut link to this study:
Publication Date: 2005 May 25
Study Author(s): Yasuda, Yoshiyuki;Kaleta, Jadwiga;Brömme, Dieter;
Institution: University of British Columbia, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, 2199 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3.
Shortcut link to this study:
Human cysteine proteases of the papain family have been recognized as potential drug targets for musculoskeletal diseases. Most of the interest is focused on cathepsins S and K, which display selective expression in cells of the immune system and cells capable to efficiently degrade extracellular matrix proteins, in particular collagens. The predominant expression of cathepsin K in osteoclasts has rendered the enzyme into a major target for the development of novel anti-resorptive drugs in osteoporosis whereas cathepsin S appears to be an attractive drug target candidate for various inflammatory diseases including rheumatoid arthritis. Since rheumatoid arthritis is at the same time an inflammatory and joint destructive disorder, the combined inhibition of both cathepsins S and K should be beneficial. This review will outline the rationale and recent progress for targeting cathepsins in arthritis and osteoporosis.
PMID: 15876399
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