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|
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result sql = The JAK2(V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates.
The JAK2(V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates.char = A;code = 65
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result sql = An association between an activating JAK2 mutation (JAK2(V617F)) and BCR/ABL-negative myeloproliferative disorders was recently reported in multiple simultaneous publications. In the current study, mutation analysis for JAK2(V617F) was performed in peripheral blood mononuclear cells (PBMC) from 157 patients with myelofibrosis with myeloid metaplasia (MMM) including 117 with agnogenic (AMM), 22 with postpolycythaemic (PPMM), and 18 with post-thrombocythaemic (PTMM) myeloid metaplasia. The detection rate for JAK2(V617F) was significantly higher in PPMM (91%; homozygous in 18%) compared with either AMM (45.3%; homozygous in 2.6%) or PTMM (38.9%; homozygous in 11.1%). Concomitant analysis in granulocytes (n=57) and CD34(+) cells (n=25) disclosed a higher incidence of homozygous JAK2(V617F) mutation but the overall mutation rate was similar to that obtained from PBMC. JAK2(V617F) was not detected in DNA derived from T cells (n=19). In AMM, the presence of JAK2(V617F) was associated with an older age at diagnosis and a history of thrombosis or pruritus. Multivariate analysis identified only age and the Dupriez prognostic score as independent prognostic factors; JAK2(V617F) had no prognostic significance. In conclusion, JAK2(V617F) is a myeloid lineage-specific event, its incidence in MMM is significantly higher with an antecedent history of polycythaemia vera (PV), and its presence in AMM does not affect prognosis but is associated with PV-characteristic clinical features.
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result sql = The JAK2(V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates.
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char = o;code = 111
char = n;code = 110
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char = J;code = 74
char = A;code = 65
char = K;code = 75
char = 2;code = 50
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char = V;code = 86
char = 6;code = 54
char = 1;code = 49
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char = );code = 41
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = C;code = 67
char = R;code = 82
char = /;code = 47
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char = B;code = 66
char = L;code = 76
char = -;code = 45
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char = g;code = 103
char = a;code = 97
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char = v;code = 118
char = e;code = 101
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char = m;code = 109
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char = e;code = 101
char = l;code = 108
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char = p;code = 112
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char = o;code = 111
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char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
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char = v;code = 118
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char = i;code = 105
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char = d;code = 100
char = e;code = 101
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char = w;code = 119
char = a;code = 97
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char = r;code = 114
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char = c;code = 99
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char = n;code = 110
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char = l;code = 108
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char = r;code = 114
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char = r;code = 114
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char = m;code = 109
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char = t;code = 116
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char = p;code = 112
char = l;code = 108
char = e;code = 101
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char = s;code = 115
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char = l;code = 108
char = t;code = 116
char = a;code = 97
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char = s;code = 115
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char = c;code = 99
char = a;code = 97
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char = s;code = 115
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char = I;code = 73
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char = t;code = 116
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char = e;code = 101
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char = r;code = 114
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char = t;code = 116
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char = t;code = 116
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char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = J;code = 74
char = A;code = 65
char = K;code = 75
char = 2;code = 50
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char = V;code = 86
char = 6;code = 54
char = 1;code = 49
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char = F;code = 70
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char = w;code = 119
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char = p;code = 112
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char = r;code = 114
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = e;code = 101
char = d;code = 100
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char = i;code = 105
char = n;code = 110
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char = p;code = 112
char = e;code = 101
char = r;code = 114
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char = p;code = 112
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
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char = b;code = 98
char = l;code = 108
char = o;code = 111
char = o;code = 111
char = d;code = 100
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char = m;code = 109
char = o;code = 111
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = (;code = 40
char = P;code = 80
char = B;code = 66
char = M;code = 77
char = C;code = 67
char = );code = 41
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = 1;code = 49
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char = ;code = 32
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char = e;code = 101
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char = t;code = 116
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = m;code = 109
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char = i;code = 105
char = b;code = 98
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = m;code = 109
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char = m;code = 109
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char = a;code = 97
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char = a;code = 97
char = s;code = 115
char = i;code = 105
char = a;code = 97
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char = M;code = 77
char = M;code = 77
char = M;code = 77
char = );code = 41
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char = 1;code = 49
char = 1;code = 49
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char = t;code = 116
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char = e;code = 101
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char = A;code = 65
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char = M;code = 77
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char = ,;code = 44
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char = 2;code = 50
char = 2;code = 50
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char = w;code = 119
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char = a;code = 97
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char = M;code = 77
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char = a;code = 97
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char = J;code = 74
char = A;code = 65
char = K;code = 75
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char = M;code = 77
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char = P;code = 80
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char = M;code = 77
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char = (;code = 40
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char = K;code = 75
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char = D;code = 68
char = N;code = 78
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char = M;code = 77
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char = J;code = 74
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char = K;code = 75
char = 2;code = 50
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char = V;code = 86
char = 6;code = 54
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result sql = An association between an activating JAK2 mutation (JAK2(V617F)) and BCR/ABL-negative myeloproliferative disorders was recently reported in multiple simultaneous publications. In the current study, mutation analysis for JAK2(V617F) was performed in peripheral blood mononuclear cells (PBMC) from 157 patients with myelofibrosis with myeloid metaplasia (MMM) including 117 with agnogenic (AMM), 22 with postpolycythaemic (PPMM), and 18 with post-thrombocythaemic (PTMM) myeloid metaplasia. The detection rate for JAK2(V617F) was significantly higher in PPMM (91%; homozygous in 18%) compared with either AMM (45.3%; homozygous in 2.6%) or PTMM (38.9%; homozygous in 11.1%). Concomitant analysis in granulocytes (n=57) and CD34(+) cells (n=25) disclosed a higher incidence of homozygous JAK2(V617F) mutation but the overall mutation rate was similar to that obtained from PBMC. JAK2(V617F) was not detected in DNA derived from T cells (n=19). In AMM, the presence of JAK2(V617F) was associated with an older age at diagnosis and a history of thrombosis or pruritus. Multivariate analysis identified only age and the Dupriez prognostic score as independent prognostic factors; JAK2(V617F) had no prognostic significance. In conclusion, JAK2(V617F) is a myeloid lineage-specific event, its incidence in MMM is significantly higher with an antecedent history of polycythaemia vera (PV), and its presence in AMM does not affect prognosis but is associated with PV-characteristic clinical features.
Publication: Br. J. Haematol. 2005 Nov ;131(3)::320-8.
Publication Date: 2005 Nov
Study Author(s): Tefferi, Ayalew;Lasho, Terra L;Schwager, Susan M;Steensma, David P;Mesa, Ruben A;Li, Chin-Yang;Wadleigh, Martha;Gary Gilliland, D;
Institution: Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN 55905, USA. [email protected]
Shortcut link to this study:
Publication Date: 2005 Nov
Study Author(s): Tefferi, Ayalew;Lasho, Terra L;Schwager, Susan M;Steensma, David P;Mesa, Ruben A;Li, Chin-Yang;Wadleigh, Martha;Gary Gilliland, D;
Institution: Mayo Clinic and Mayo Clinic College of Medicine, Rochester, MN 55905, USA. [email protected]
Shortcut link to this study:
An association between an activating JAK2 mutation (JAK2(V617F)) and BCR/ABL-negative myeloproliferative disorders was recently reported in multiple simultaneous publications. In the current study, mutation analysis for JAK2(V617F) was performed in peripheral blood mononuclear cells (PBMC) from 157 patients with myelofibrosis with myeloid metaplasia (MMM) including 117 with agnogenic (AMM), 22 with postpolycythaemic (PPMM), and 18 with post-thrombocythaemic (PTMM) myeloid metaplasia. The detection rate for JAK2(V617F) was significantly higher in PPMM (91%; homozygous in 18%) compared with either AMM (45.3%; homozygous in 2.6%) or PTMM (38.9%; homozygous in 11.1%). Concomitant analysis in granulocytes (n=57) and CD34(+) cells (n=25) disclosed a higher incidence of homozygous JAK2(V617F) mutation but the overall mutation rate was similar to that obtained from PBMC. JAK2(V617F) was not detected in DNA derived from T cells (n=19). In AMM, the presence of JAK2(V617F) was associated with an older age at diagnosis and a history of thrombosis or pruritus. Multivariate analysis identified only age and the Dupriez prognostic score as independent prognostic factors; JAK2(V617F) had no prognostic significance. In conclusion, JAK2(V617F) is a myeloid lineage-specific event, its incidence in MMM is significantly higher with an antecedent history of polycythaemia vera (PV), and its presence in AMM does not affect prognosis but is associated with PV-characteristic clinical features.
PMID: 16225651
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