|
|
char = I;code = 73
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char = s;code = 115
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char = h;code = 104
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char = w;code = 119
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char = m;code = 109
char = e;code = 101
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result sql = Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women.
Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women.char = <;code = 60
char = b;code = 98
char = >;code = 62
char = O;code = 79
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char = J;code = 74
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char = C;code = 67
char = T;code = 84
char = I;code = 73
char = V;code = 86
char = E;code = 69
char = S;code = 83
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char = :;code = 58
char = ;code = 32
char = <;code = 60
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char = T;code = 84
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char = l;code = 108
char = u;code = 117
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char = h;code = 104
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char = f;code = 102
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char = n;code = 110
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char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = D;code = 68
char = E;code = 69
char = S;code = 83
char = I;code = 73
char = G;code = 71
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char = ;code = 32
char = A;code = 65
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char = D;code = 68
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char = M;code = 77
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char = H;code = 72
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char = <;code = 60
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char = b;code = 98
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char = e;code = 101
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char = t;code = 116
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char = o;code = 111
char = b;code = 98
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char = r;code = 114
char = b;code = 98
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char = u;code = 117
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char = i;code = 105
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char = b;code = 98
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char = n;code = 110
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char = T;code = 84
char = B;code = 66
char = A;code = 65
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char = S;code = 83
char = );code = 41
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char = l;code = 108
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char = C;code = 67
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char = c;code = 99
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char = ;code = 32
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char = d;code = 100
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char = a;code = 97
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char = b;code = 98
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char = A;code = 65
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char = D;code = 68
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char = l;code = 108
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
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char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = 4;code = 52
char = 6;code = 54
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
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char = ;code = 32
char = p;code = 112
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char = i;code = 105
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = 4;code = 52
char = 6;code = 54
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = -;code = 45
char = s;code = 115
char = e;code = 101
char = x;code = 120
char = -;code = 45
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = c;code = 99
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char = e;code = 101
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char = c;code = 99
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char = l;code = 108
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char = .;code = 46
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char = <;code = 60
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char = <;code = 60
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char = R;code = 82
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char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
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char = <;code = 60
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char = b;code = 98
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char = c;code = 99
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char = A;code = 65
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char = g;code = 103
char = h;code = 104
char = e;code = 101
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char = i;code = 105
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char = h;code = 104
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = ;code = 32
char = g;code = 103
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char = ;code = 32
char = w;code = 119
char = h;code = 104
char = e;code = 101
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char = c;code = 99
char = o;code = 111
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
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char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = <;code = 60
char = b;code = 98
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char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = ;code = 32
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char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
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char = S;code = 83
char = I;code = 73
char = L;code = 76
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char = S;code = 83
char = I;code = 73
char = L;code = 76
char = ;code = 32
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char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = c;code = 99
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char = l;code = 108
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = c;code = 99
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char = b;code = 98
char = e;code = 101
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char = s;code = 115
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char = t;code = 116
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char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
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char = g;code = 103
char = e;code = 101
char = s;code = 115
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char = ;code = 32
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char = i;code = 105
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char = r;code = 114
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = i;code = 105
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char = s;code = 115
char = s;code = 115
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char = e;code = 101
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char = n;code = 110
char = ;code = 32
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = r;code = 114
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char = e;code = 101
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char = A;code = 65
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char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
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char = ;code = 32
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char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = C;code = 67
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ,;code = 44
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = l;code = 108
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char = y;code = 121
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = o;code = 111
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char = n;code = 110
char = t;code = 116
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char = r;code = 114
char = o;code = 111
char = l;code = 108
char = e;code = 101
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char = n;code = 110
char = ;code = 32
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char = a;code = 97
char = r;code = 114
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
result sql = OBJECTIVES : To evaluate the potential role of oxidative stress in the evolution of cervical cancer, including its pre-malignant states.
DESIGN AND METHODS : Erythrocytes thiobarbituric acid reactive substances (TBARS) levels, plasma vitamin C and thiol content and total blood delta-ALA-D levels were estimated in 46 untreated cervical cancer and pre-malignant patients and in 46 age-sex-matched controls.
RESULTS : Erythrocytes from patients, regardless of disease state, pre-malignant (low squamous intraepithelial lesion--LSIL and high squamous intraepithelial lesion--HSIL) or cancer, showed a significant 2-3 times increase in TBARS levels (P<0.01). Plasma vitamin C was lower in the carcinoma group (P<0.01). The reactivation index of delta-aminolevulinate dehydratase (delta-ALA-D) was higher in the patient group, when compared to control (P<0.01).
CONCLUSION : LSIL, HSIL or cervical cancer can be associated with changes in 3 indicators of oxidative stress: increase in erythrocyte TBARS, ALA-D reactivation index and a decrease in vitamin C content, that may play an important role in carcinogenesis.
char = n;code = 110
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char = f;code = 102
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char = a;code = 97
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char = i;code = 105
char = v;code = 118
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char = t;code = 116
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char = e;code = 101
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char = w;code = 119
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char = e;code = 101
char = n;code = 110
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result sql = Involvement of oxidative stress in the pre-malignant and malignant states of cervical cancer in women.
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char = o;code = 111
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char = t;code = 116
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char = t;code = 116
char = ;code = 32
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = g;code = 103
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result sql = OBJECTIVES : To evaluate the potential role of oxidative stress in the evolution of cervical cancer, including its pre-malignant states.
DESIGN AND METHODS : Erythrocytes thiobarbituric acid reactive substances (TBARS) levels, plasma vitamin C and thiol content and total blood delta-ALA-D levels were estimated in 46 untreated cervical cancer and pre-malignant patients and in 46 age-sex-matched controls.
RESULTS : Erythrocytes from patients, regardless of disease state, pre-malignant (low squamous intraepithelial lesion--LSIL and high squamous intraepithelial lesion--HSIL) or cancer, showed a significant 2-3 times increase in TBARS levels (P<0.01). Plasma vitamin C was lower in the carcinoma group (P<0.01). The reactivation index of delta-aminolevulinate dehydratase (delta-ALA-D) was higher in the patient group, when compared to control (P<0.01).
CONCLUSION : LSIL, HSIL or cervical cancer can be associated with changes in 3 indicators of oxidative stress: increase in erythrocyte TBARS, ALA-D reactivation index and a decrease in vitamin C content, that may play an important role in carcinogenesis.
Publication: Clin. Biochem. 2005 Dec ;38(12)::1071-5.
Publication Date: 2005 Dec
Study Author(s): Gonçalves, Thissiane L;Erthal, Fernando;Corte, Cristiane L D;Müller, Liz G;Piovezan, Clarice M;Nogueira, Cristina W;Rocha, João B T;
Institution: Departamento de Química, CCNE, Universidade Federal de Santa Maria, 97105-900 Santa Maria, R.S., Brazil.
Shortcut link to this study:
Publication Date: 2005 Dec
Study Author(s): Gonçalves, Thissiane L;Erthal, Fernando;Corte, Cristiane L D;Müller, Liz G;Piovezan, Clarice M;Nogueira, Cristina W;Rocha, João B T;
Institution: Departamento de Química, CCNE, Universidade Federal de Santa Maria, 97105-900 Santa Maria, R.S., Brazil.
Shortcut link to this study:
OBJECTIVES : To evaluate the potential role of oxidative stress in the evolution of cervical cancer, including its pre-malignant states.
DESIGN AND METHODS : Erythrocytes thiobarbituric acid reactive substances (TBARS) levels, plasma vitamin C and thiol content and total blood delta-ALA-D levels were estimated in 46 untreated cervical cancer and pre-malignant patients and in 46 age-sex-matched controls.
RESULTS : Erythrocytes from patients, regardless of disease state, pre-malignant (low squamous intraepithelial lesion--LSIL and high squamous intraepithelial lesion--HSIL) or cancer, showed a significant 2-3 times increase in TBARS levels (P<0.01). Plasma vitamin C was lower in the carcinoma group (P<0.01). The reactivation index of delta-aminolevulinate dehydratase (delta-ALA-D) was higher in the patient group, when compared to control (P<0.01).
CONCLUSION : LSIL, HSIL or cervical cancer can be associated with changes in 3 indicators of oxidative stress: increase in erythrocyte TBARS, ALA-D reactivation index and a decrease in vitamin C content, that may play an important role in carcinogenesis.
DESIGN AND METHODS : Erythrocytes thiobarbituric acid reactive substances (TBARS) levels, plasma vitamin C and thiol content and total blood delta-ALA-D levels were estimated in 46 untreated cervical cancer and pre-malignant patients and in 46 age-sex-matched controls.
RESULTS : Erythrocytes from patients, regardless of disease state, pre-malignant (low squamous intraepithelial lesion--LSIL and high squamous intraepithelial lesion--HSIL) or cancer, showed a significant 2-3 times increase in TBARS levels (P<0.01). Plasma vitamin C was lower in the carcinoma group (P<0.01). The reactivation index of delta-aminolevulinate dehydratase (delta-ALA-D) was higher in the patient group, when compared to control (P<0.01).
CONCLUSION : LSIL, HSIL or cervical cancer can be associated with changes in 3 indicators of oxidative stress: increase in erythrocyte TBARS, ALA-D reactivation index and a decrease in vitamin C content, that may play an important role in carcinogenesis.
PMID: 16269141
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