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result sql = Efficacy and tolerability of Ketotifen in Nepalese asthmatic children: a clinical study.
Efficacy and tolerability of Ketotifen in Nepalese asthmatic children: a clinical study.
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char = e;code = 101
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char = n;code = 110
char = ;code = 32
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char = e;code = 101
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char = o;code = 111
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char = t;code = 116
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char = m;code = 109
char = a;code = 97
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char = n;code = 110
char = ;code = 32
char = c;code = 99
char = h;code = 104
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result sql = OBJECTIVE : To assess the efficacy of Ketotifen in asthmatic children and to record its adverse effects, if any.

DESIGN : Prospective clinical trial.

SETTING : Pediatric asthma follow up clinic of a teaching hospital.

PARTICIPANTS : 23 asthmatic children between 3 and 15 years; 100% completed the trial on full protocol.

INTERVENTIONS : Ketotifen 1mg (adjusted according to body weight, 50 mcg/kg/dose) orally twice daily for 9 months.

MAIN OUTCOME MEASURES : Primary outcome: Decrease in frequency of asthmatic attacks and severity of exacerbations with improvements in peak expiratory flow rates (PEFR). Other measures included decrease in bronchodilator requirement, steroid doses and parental perception regarding patient quality of life.

RESULTS : 34.78% children were symptom free by the end of 2nd 3 months and 65.21% had no further attack by the end of 3rd 3 months of Ketotifen prophylaxis. Those children with activity and sleep 'affected' (8.69%) and 'may be affected' (30.43%) together improved to 'may be affected' group (21.73%) by the end of 2nd 3 months and further reduced to 8.69% by the conclusion of 3rd 3 months. The duration of exacerbations was reduced in the remaining cases. Variability of PEFR decreased from 26.08% to 8.69% of children after the 3rd 3 months of Ketotifen prophylaxis. No significant adverse effect of therapy was observed during the study.

CONCLUSION : Oral Ketotifen is effective and well tolerated for use in prophylactic treatment of bronchial asthma in children.

Publication: Kathmandu Univ Med J (KUMJ) 2003 Oct-Dec ;1(4)::242-7.
Publication Date: 2003 Oct-Dec
Study Author(s): Shakya, K N;Joshi, P;Piya, A;Baral, M R;
Institution: Kathmandu Medical College, Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Shortcut link to this study:
OBJECTIVE : To assess the efficacy of Ketotifen in asthmatic children and to record its adverse effects, if any.

DESIGN : Prospective clinical trial.

SETTING : Pediatric asthma follow up clinic of a teaching hospital.

PARTICIPANTS : 23 asthmatic children between 3 and 15 years; 100% completed the trial on full protocol.

INTERVENTIONS : Ketotifen 1mg (adjusted according to body weight, 50 mcg/kg/dose) orally twice daily for 9 months.

MAIN OUTCOME MEASURES : Primary outcome: Decrease in frequency of asthmatic attacks and severity of exacerbations with improvements in peak expiratory flow rates (PEFR). Other measures included decrease in bronchodilator requirement, steroid doses and parental perception regarding patient quality of life.

RESULTS : 34.78% children were symptom free by the end of 2nd 3 months and 65.21% had no further attack by the end of 3rd 3 months of Ketotifen prophylaxis. Those children with activity and sleep 'affected' (8.69%) and 'may be affected' (30.43%) together improved to 'may be affected' group (21.73%) by the end of 2nd 3 months and further reduced to 8.69% by the conclusion of 3rd 3 months. The duration of exacerbations was reduced in the remaining cases. Variability of PEFR decreased from 26.08% to 8.69% of children after the 3rd 3 months of Ketotifen prophylaxis. No significant adverse effect of therapy was observed during the study.

CONCLUSION : Oral Ketotifen is effective and well tolerated for use in prophylactic treatment of bronchial asthma in children.
PMID: 16388263

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