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result sql = Insecticides are one of the major tools for controlling vector populations and for reducing the transmission of human pathogens. However, there are few new insecticides being developed and marketed for vector control. Herein, we report on the toxicity of six novel insecticides to both adult and larval Aedes aegypti (L). and the toxicity of three novel insect growth regulators (IGRs) to larvae. Four insecticides were highly or moderately toxic to larvae with LC50 values of 16 (chlorfenapyr), 70 (hydramethylnon), 79 (indoxacarb), and 84 ng/ml (imidacloprid). Diafenthiuron and chlorfenapyr were moderately toxic to adult mosquitoes with LC50 values of 13 and 92 ng/cm2, respectively. Imidacloprid was strongly synergized by piperonyl butoxide (PBO) in Ae. aegypti adults, suggesting that neonicotinoids are intrinsically very toxic to adult mosquitoes (in the absence of detoxification). The effect of PBO on the toxicity in adults and larvae was considerably different, both in terms of the insecticides that were synergized (or antagonized for chlorfenapyr versus adults) and in terms of the degree of synergism. This result implies that the cytochrome P450s involved in metabolism of these insecticides are different between adults and larvae. Pyriproxyfen was confirmed as a potent IGR (EC50 of 0.0017 ng/ml) for mosquitoes, although tebufenozide lacked activity. The potential for use of these materials in mosquito control is discussed.
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result sql = Evaluation of novel insecticides for control of dengue vector Aedes aegypti (Diptera: Culicidae).
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char = s;code = 115
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = i;code = 105
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char = ;code = 32
char = d;code = 100
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = r;code = 114
char = k;code = 107
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = v;code = 118
char = e;code = 101
char = c;code = 99
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char = o;code = 111
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = x;code = 120
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = c;code = 99
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char = i;code = 105
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = o;code = 111
char = t;code = 116
char = h;code = 104
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char = a;code = 97
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char = u;code = 117
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char = t;code = 116
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = A;code = 65
char = e;code = 101
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = e;code = 101
char = g;code = 103
char = y;code = 121
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = ;code = 32
char = (;code = 40
char = L;code = 76
char = );code = 41
char = .;code = 46
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = e;code = 101
char = e;code = 101
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char = n;code = 110
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = G;code = 71
char = R;code = 82
char = s;code = 115
char = );code = 41
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = v;code = 118
char = a;code = 97
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = F;code = 70
char = o;code = 111
char = u;code = 117
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
char = e;code = 101
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char = a;code = 97
char = t;code = 116
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = v;code = 118
char = a;code = 97
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = L;code = 76
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 1;code = 49
char = 6;code = 54
char = ;code = 32
char = (;code = 40
char = c;code = 99
char = h;code = 104
char = l;code = 108
char = o;code = 111
char = r;code = 114
char = f;code = 102
char = e;code = 101
char = n;code = 110
char = a;code = 97
char = p;code = 112
char = y;code = 121
char = r;code = 114
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = 7;code = 55
char = 0;code = 48
char = ;code = 32
char = (;code = 40
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = a;code = 97
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = 7;code = 55
char = 9;code = 57
char = ;code = 32
char = (;code = 40
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = o;code = 111
char = x;code = 120
char = a;code = 97
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = b;code = 98
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = 8;code = 56
char = 4;code = 52
char = ;code = 32
char = n;code = 110
char = g;code = 103
char = /;code = 47
char = m;code = 109
char = l;code = 108
char = ;code = 32
char = (;code = 40
char = i;code = 105
char = m;code = 109
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char = d;code = 100
char = a;code = 97
char = c;code = 99
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = i;code = 105
char = d;code = 100
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char = .;code = 46
char = ;code = 32
char = D;code = 68
char = i;code = 105
char = a;code = 97
char = f;code = 102
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = u;code = 117
char = r;code = 114
char = o;code = 111
char = n;code = 110
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = l;code = 108
char = o;code = 111
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char = f;code = 102
char = e;code = 101
char = n;code = 110
char = a;code = 97
char = p;code = 112
char = y;code = 121
char = r;code = 114
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char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = o;code = 111
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char = a;code = 97
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char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
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char = u;code = 117
char = l;code = 108
char = t;code = 116
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char = m;code = 109
char = o;code = 111
char = s;code = 115
char = q;code = 113
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char = i;code = 105
char = t;code = 116
char = o;code = 111
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = L;code = 76
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 1;code = 49
char = 3;code = 51
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = 9;code = 57
char = 2;code = 50
char = ;code = 32
char = n;code = 110
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char = /;code = 47
char = c;code = 99
char = m;code = 109
char = 2;code = 50
char = ,;code = 44
char = ;code = 32
char = r;code = 114
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char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = m;code = 109
char = i;code = 105
char = d;code = 100
char = a;code = 97
char = c;code = 99
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = l;code = 108
char = y;code = 121
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char = s;code = 115
char = y;code = 121
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char = e;code = 101
char = r;code = 114
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char = i;code = 105
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
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char = p;code = 112
char = i;code = 105
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = o;code = 111
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char = y;code = 121
char = l;code = 108
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char = u;code = 117
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = B;code = 66
char = O;code = 79
char = );code = 41
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = A;code = 65
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = a;code = 97
char = e;code = 101
char = g;code = 103
char = y;code = 121
char = p;code = 112
char = t;code = 116
char = i;code = 105
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char = a;code = 97
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char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = s;code = 115
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char = g;code = 103
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = t;code = 116
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char = a;code = 97
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char = o;code = 111
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char = i;code = 105
char = c;code = 99
char = o;code = 111
char = t;code = 116
char = i;code = 105
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
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char = n;code = 110
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char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
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char = v;code = 118
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char = r;code = 114
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char = t;code = 116
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char = i;code = 105
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char = i;code = 105
char = o;code = 111
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char = .;code = 46
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char = T;code = 84
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char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = o;code = 111
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char = ;code = 32
char = P;code = 80
char = B;code = 66
char = O;code = 79
char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = u;code = 117
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char = a;code = 97
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char = a;code = 97
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char = w;code = 119
char = a;code = 97
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char = a;code = 97
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char = t;code = 116
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char = a;code = 97
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char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = y;code = 121
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char = i;code = 105
char = z;code = 122
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char = a;code = 97
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char = z;code = 122
char = e;code = 101
char = d;code = 100
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = c;code = 99
char = h;code = 104
char = l;code = 108
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char = f;code = 102
char = e;code = 101
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char = a;code = 97
char = p;code = 112
char = y;code = 121
char = r;code = 114
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char = v;code = 118
char = e;code = 101
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char = u;code = 117
char = s;code = 115
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char = t;code = 116
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char = );code = 41
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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result sql = Insecticides are one of the major tools for controlling vector populations and for reducing the transmission of human pathogens. However, there are few new insecticides being developed and marketed for vector control. Herein, we report on the toxicity of six novel insecticides to both adult and larval Aedes aegypti (L). and the toxicity of three novel insect growth regulators (IGRs) to larvae. Four insecticides were highly or moderately toxic to larvae with LC50 values of 16 (chlorfenapyr), 70 (hydramethylnon), 79 (indoxacarb), and 84 ng/ml (imidacloprid). Diafenthiuron and chlorfenapyr were moderately toxic to adult mosquitoes with LC50 values of 13 and 92 ng/cm2, respectively. Imidacloprid was strongly synergized by piperonyl butoxide (PBO) in Ae. aegypti adults, suggesting that neonicotinoids are intrinsically very toxic to adult mosquitoes (in the absence of detoxification). The effect of PBO on the toxicity in adults and larvae was considerably different, both in terms of the insecticides that were synergized (or antagonized for chlorfenapyr versus adults) and in terms of the degree of synergism. This result implies that the cytochrome P450s involved in metabolism of these insecticides are different between adults and larvae. Pyriproxyfen was confirmed as a potent IGR (EC50 of 0.0017 ng/ml) for mosquitoes, although tebufenozide lacked activity. The potential for use of these materials in mosquito control is discussed.
Publication: J. Med. Entomol. 2006 Jan ;43(1)::55-60.
Publication Date: 2006 Jan
Study Author(s): Paul, Ayesa;Harrington, Laura C;Scott, Jeffrey G;
Institution: Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853, USA.
Shortcut link to this study:
Publication Date: 2006 Jan
Study Author(s): Paul, Ayesa;Harrington, Laura C;Scott, Jeffrey G;
Institution: Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY 14853, USA.
Shortcut link to this study:
Insecticides are one of the major tools for controlling vector populations and for reducing the transmission of human pathogens. However, there are few new insecticides being developed and marketed for vector control. Herein, we report on the toxicity of six novel insecticides to both adult and larval Aedes aegypti (L). and the toxicity of three novel insect growth regulators (IGRs) to larvae. Four insecticides were highly or moderately toxic to larvae with LC50 values of 16 (chlorfenapyr), 70 (hydramethylnon), 79 (indoxacarb), and 84 ng/ml (imidacloprid). Diafenthiuron and chlorfenapyr were moderately toxic to adult mosquitoes with LC50 values of 13 and 92 ng/cm2, respectively. Imidacloprid was strongly synergized by piperonyl butoxide (PBO) in Ae. aegypti adults, suggesting that neonicotinoids are intrinsically very toxic to adult mosquitoes (in the absence of detoxification). The effect of PBO on the toxicity in adults and larvae was considerably different, both in terms of the insecticides that were synergized (or antagonized for chlorfenapyr versus adults) and in terms of the degree of synergism. This result implies that the cytochrome P450s involved in metabolism of these insecticides are different between adults and larvae. Pyriproxyfen was confirmed as a potent IGR (EC50 of 0.0017 ng/ml) for mosquitoes, although tebufenozide lacked activity. The potential for use of these materials in mosquito control is discussed.
PMID: 16506447
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