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result sql = Influence of toluene intoxication on the number of mitral and granular neurons in olfactory bulbs of rats.
Influence of toluene intoxication on the number of mitral and granular neurons in olfactory bulbs of rats.
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char = I;code = 73
char = S;code = 83
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char = D;code = 68
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char = N;code = 78
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char = I;code = 73
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char = I;code = 73
char = I;code = 73
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char = t;code = 116
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char = l;code = 108
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char = ;code = 32
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char = s;code = 115
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char = n;code = 110
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char = e;code = 101
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char = o;code = 111
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char = t;code = 116
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char = n;code = 110
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char = i;code = 105
char = f;code = 102
char = f;code = 102
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char = t;code = 116
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char = t;code = 116
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char = c;code = 99
char = t;code = 116
char = u;code = 117
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char = w;code = 119
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = c;code = 99
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char = d;code = 100
char = i;code = 105
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char = ;code = 32
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char = o;code = 111
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char = t;code = 116
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char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = l;code = 108
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char = a;code = 97
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char = o;code = 111
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char = m;code = 109
char = e;code = 101
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char = o;code = 111
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char = r;code = 114
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char = p;code = 112
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char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = y;code = 121
char = ;code = 32
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char = e;code = 101
char = s;code = 115
char = t;code = 116
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char = (;code = 40
char = 1;code = 49
char = 9;code = 57
char = 9;code = 57
char = 9;code = 57
char = );code = 41
char = .;code = 46
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = ;code = 32
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char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = b;code = 98
char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = ;code = 32
char = s;code = 115
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = m;code = 109
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char = ;code = 32
char = o;code = 111
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char = ;code = 32
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char = l;code = 108
char = ;code = 32
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char = r;code = 114
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char = l;code = 108
char = b;code = 98
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = g;code = 103
char = r;code = 114
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char = I;code = 73
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char = ,;code = 44
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char = i;code = 105
char = n;code = 110
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char = i;code = 105
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char = y;code = 121
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char = d;code = 100
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char = ,;code = 44
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char = ;code = 32
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char = y;code = 121
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char = %;code = 37
char = ;code = 32
char = (;code = 40
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char = 0;code = 48
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char = 0;code = 48
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char = );code = 41
char = ,;code = 44
char = ;code = 32
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char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = e;code = 101
char = a;code = 97
char = n;code = 110
char = w;code = 119
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char = i;code = 105
char = l;code = 108
char = e;code = 101
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char = ;code = 32
char = t;code = 116
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char = r;code = 114
char = a;code = 97
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char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = b;code = 98
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = D;code = 68
char = e;code = 101
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = u;code = 117
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = r;code = 114
char = u;code = 117
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = o;code = 111
char = l;code = 108
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = e;code = 101
char = x;code = 120
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = m;code = 109
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = f;code = 102
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = l;code = 108
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = y;code = 121
char = z;code = 122
char = e;code = 101
char = r;code = 114
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = In the last years, implementation of the volatile solvents in order to get a narcotic high, used via inhalation (sniffing), increased significantly, especially in the youth. Substances containing these agents induce hallucinations and euphoric state. In the present study the influences of toluene intoxication on quantity of the mitral and granular cells in olfactory bulbs was analyzed in young and adult rats. An inhalation route of intoxication was used in our experiments - animal inhaled toluene until attaining a sidewise laying position. This procedure was performed in the closed glass container, in which air was beforehand saturated with the toluene vapours. Experiments was carried out on two age groups (n=20 animals): one - and two months age rats. Inhalation period was 40 days. EACH AGE GROUP CONSISTED OF TEN ANIMALS AND WAS DIVIDED INTO THE TWO SUBGROUPS: I - control animals (n=5), II - experimental animals (n=5). Assessment of the neurons' quantity in different structures was made according to the fractional approach method proposed by M. West (1999). The results obtained showed that number of mitral neurons in the olfactory bulb of the Subgroup II of the rats, sniffing since the age of one and two months, significantly decreased by 43% (p<0,05) and by 28% (p<0,01), respectively. Meanwhile, the granular cells remained unaltered in experimental animals of both age groups. Decrease of the projection mitral neurons, in its turn, results in disruption of the projections to olfactory cortex and hampers proper functioning of the olfactory analyzer.

Publication: Georgian Med News 2006 Apr ;(133)::99-101.
Publication Date: 2006 Apr
Study Author(s): Gelazonia, L;Japaridze, N;Maglakelidze, G;Svanidze, I;
Institution: Institute of Physiology Georgian Academy of Science, Tbilisi.
Shortcut link to this study:
In the last years, implementation of the volatile solvents in order to get a narcotic high, used via inhalation (sniffing), increased significantly, especially in the youth. Substances containing these agents induce hallucinations and euphoric state. In the present study the influences of toluene intoxication on quantity of the mitral and granular cells in olfactory bulbs was analyzed in young and adult rats. An inhalation route of intoxication was used in our experiments - animal inhaled toluene until attaining a sidewise laying position. This procedure was performed in the closed glass container, in which air was beforehand saturated with the toluene vapours. Experiments was carried out on two age groups (n=20 animals): one - and two months age rats. Inhalation period was 40 days. EACH AGE GROUP CONSISTED OF TEN ANIMALS AND WAS DIVIDED INTO THE TWO SUBGROUPS: I - control animals (n=5), II - experimental animals (n=5). Assessment of the neurons' quantity in different structures was made according to the fractional approach method proposed by M. West (1999). The results obtained showed that number of mitral neurons in the olfactory bulb of the Subgroup II of the rats, sniffing since the age of one and two months, significantly decreased by 43% (p<0,05) and by 28% (p<0,01), respectively. Meanwhile, the granular cells remained unaltered in experimental animals of both age groups. Decrease of the projection mitral neurons, in its turn, results in disruption of the projections to olfactory cortex and hampers proper functioning of the olfactory analyzer.
PMID: 16705243

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