char = E;code = 69
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = s;code = 115
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = (;code = 40
char = V;code = 86
char = 1;code = 49
char = b;code = 98
char = );code = 41
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = r;code = 114
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char = a;code = 97
char = n;code = 110
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char = a;code = 97
char = g;code = 103
char = o;code = 111
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char = s;code = 115
char = t;code = 116
char = ,;code = 44
char = ;code = 32
char = S;code = 83
char = S;code = 83
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char = 1;code = 49
char = 4;code = 52
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char = 4;code = 52
char = 1;code = 49
char = 5;code = 53
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = i;code = 105
char = n;code = 110
char = -;code = 45
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = 1;code = 49
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = g;code = 103
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = ,;code = 44
char = ;code = 32
char = S;code = 83
char = S;code = 83
char = R;code = 82
char = 1;code = 49
char = 2;code = 50
char = 5;code = 53
char = 5;code = 53
char = 4;code = 52
char = 3;code = 51
char = ,;code = 44
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = F;code = 70
char = G;code = 71
char = ;code = 32
char = 7;code = 55
char = 1;code = 49
char = 4;code = 52
char = 2;code = 50
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = y;code = 121
char = l;code = 108
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = p;code = 112
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = p;code = 112
char = h;code = 104
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = .;code = 46
result sql = Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat.
Effects of the vasopressin (V1b) receptor antagonist, SSR149415, and the corticotropin-releasing factor 1 receptor antagonist, SSR125543, on FG 7142-induced increase in acetylcholine and norepinephrine release in the rat.
char = A;code = 65
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char = g;code = 103
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = s;code = 115
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = c;code = 99
char = o;code = 111
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char = r;code = 114
char = o;code = 111
char = p;code = 112
char = i;code = 105
char = n;code = 110
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char = r;code = 114
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
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char = r;code = 114
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char = ;code = 32
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char = g;code = 103
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char = l;code = 108
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char = t;code = 116
char = e;code = 101
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char = h;code = 104
char = y;code = 121
char = p;code = 112
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char = h;code = 104
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char = l;code = 108
char = a;code = 97
char = m;code = 109
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char = u;code = 117
char = i;code = 105
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char = a;code = 97
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char = s;code = 115
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char = e;code = 101
char = d;code = 100
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char = s;code = 115
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char = W;code = 87
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char = a;code = 97
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char = k;code = 107
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char = f;code = 102
char = ;code = 32
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char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = p;code = 112
char = p;code = 112
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char = a;code = 97
char = m;code = 109
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char = a;code = 97
char = l;code = 108
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char = c;code = 99
char = h;code = 104
char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = e;code = 101
char = r;code = 114
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = r;code = 114
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = n;code = 110
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char = r;code = 114
char = a;code = 97
char = d;code = 100
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = s;code = 115
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char = s;code = 115
char = t;code = 116
char = e;code = 101
char = m;code = 109
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = x;code = 120
char = i;code = 105
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
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char = b;code = 98
char = e;code = 101
char = n;code = 110
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char = o;code = 111
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = z;code = 122
char = e;code = 101
char = p;code = 112
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = r;code = 114
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char = i;code = 105
char = n;code = 110
char = v;code = 118
char = e;code = 101
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char = s;code = 115
char = e;code = 101
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char = a;code = 97
char = g;code = 103
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = F;code = 70
char = G;code = 71
char = ;code = 32
char = 7;code = 55
char = 1;code = 49
char = 4;code = 52
char = 2;code = 50
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char = ;code = 32
char = A;code = 65
char = c;code = 99
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = ;code = 32
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char = 3;code = 51
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char = 1;code = 49
char = 0;code = 48
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char = m;code = 109
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char = k;code = 107
char = g;code = 103
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char = ;code = 32
char = i;code = 105
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char = p;code = 112
char = .;code = 46
char = );code = 41
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = -;code = 45
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = m;code = 109
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char = n;code = 110
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = (;code = 40
char = 1;code = 49
char = 0;code = 48
char = ;code = 32
char = m;code = 109
char = g;code = 103
char = /;code = 47
char = k;code = 107
char = g;code = 103
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = .;code = 46
char = p;code = 112
char = .;code = 46
char = ,;code = 44
char = ;code = 32
char = 2;code = 50
char = 1;code = 49
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = y;code = 121
char = s;code = 115
char = );code = 41
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = S;code = 83
char = S;code = 83
char = R;code = 82
char = 1;code = 49
char = 4;code = 52
char = 9;code = 57
char = 4;code = 52
char = 1;code = 49
char = 5;code = 53
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = S;code = 83
char = S;code = 83
char = R;code = 82
char = 1;code = 49
char = 2;code = 50
char = 5;code = 53
char = 5;code = 53
char = 4;code = 52
char = 3;code = 51
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = F;code = 70
char = G;code = 71
char = ;code = 32
char = 7;code = 55
char = 1;code = 49
char = 4;code = 52
char = 2;code = 50
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = y;code = 121
char = l;code = 108
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = p;code = 112
char = p;code = 112
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = m;code = 109
char = p;code = 112
char = u;code = 117
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
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char = m;code = 109
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
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char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = B;code = 66
char = y;code = 121
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = t;code = 116
char = e;code = 101
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = l;code = 108
char = o;code = 111
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char = g;code = 103
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char = t;code = 116
char = e;code = 101
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char = m;code = 109
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char = a;code = 97
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char = m;code = 109
char = i;code = 105
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = S;code = 83
char = S;code = 83
char = R;code = 82
char = 1;code = 49
char = 4;code = 52
char = 9;code = 57
char = 4;code = 52
char = 1;code = 49
char = 5;code = 53
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char = f;code = 102
char = a;code = 97
char = i;code = 105
char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = F;code = 70
char = G;code = 71
char = ;code = 32
char = 7;code = 55
char = 1;code = 49
char = 4;code = 52
char = 2;code = 50
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
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char = e;code = 101
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char = i;code = 105
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char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = e;code = 101
char = l;code = 108
char = e;code = 101
char = a;code = 97
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = n;code = 110
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char = p;code = 112
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char = h;code = 104
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char = n;code = 110
char = e;code = 101
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char = i;code = 105
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char = e;code = 101
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char = ;code = 32
char = f;code = 102
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char = e;code = 101
char = e;code = 101
char = l;code = 108
char = y;code = 121
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char = o;code = 111
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
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char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
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char = n;code = 110
char = t;code = 116
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char = r;code = 114
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char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
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char = d;code = 100
char = e;code = 101
char = m;code = 109
char = o;code = 111
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char = t;code = 116
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = t;code = 116
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char = e;code = 101
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char = t;code = 116
char = w;code = 119
char = o;code = 111
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char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
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char = u;code = 117
char = n;code = 110
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char = s;code = 115
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char = h;code = 104
char = a;code = 97
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char = e;code = 101
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char = s;code = 115
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char = i;code = 105
char = l;code = 108
char = a;code = 97
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char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = l;code = 108
char = e;code = 101
char = s;code = 115
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char = ;code = 32
char = a;code = 97
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char = o;code = 111
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = t;code = 116
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char = g;code = 103
char = e;code = 101
char = s;code = 115
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = S;code = 83
char = S;code = 83
char = R;code = 82
char = 1;code = 49
char = 4;code = 52
char = 9;code = 57
char = 4;code = 52
char = 1;code = 49
char = 5;code = 53
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = S;code = 83
char = S;code = 83
char = R;code = 82
char = 1;code = 49
char = 2;code = 50
char = 5;code = 53
char = 5;code = 53
char = 4;code = 52
char = 3;code = 51
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char = m;code = 109
char = a;code = 97
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char = h;code = 104
char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = t;code = 116
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char = s;code = 115
char = t;code = 116
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char = s;code = 115
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char = a;code = 97
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char = i;code = 105
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char = l;code = 108
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char = p;code = 112
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char = a;code = 97
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = v;code = 118
char = i;code = 105
char = a;code = 97
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char = a;code = 97
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char = m;code = 109
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char = a;code = 97
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
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char = a;code = 97
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char = f;code = 102
char = e;code = 101
char = r;code = 114
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char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = c;code = 99
char = l;code = 108
char = a;code = 97
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char = c;code = 99
char = a;code = 97
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char = b;code = 98
char = e;code = 101
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char = o;code = 111
char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = p;code = 112
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char = e;code = 101
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char = l;code = 108
char = i;code = 105
char = g;code = 103
char = a;code = 97
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char = s;code = 115
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
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result sql = Arginine vasopressin and corticotropin-releasing factor are two neuroactive peptides that regulate hypothalamic-pituitary-axis and associated stress response. While the potential antidepressant and anxiolytic profiles of corticotropin-releasing factor 1 antagonists have been well studied, the concept of blockade of vasopressin system as another approach for the treatment of emotional processes has only been made available recently by the synthesis of the first non-peptide antagonist at the V1b receptor, SSR149415. In the present study SSR149415 has been compared with the corticotropin-releasing factor 1 antagonist SSR125543 and with anxiolytic and antidepressant drugs on the response of hippocampal cholinergic and cortical noradrenergic systems to the anxiogenic benzodiazepine receptor inverse agonist FG 7142. Acute (0.3-10 mg/kg, i.p.) and long-term administration (10 mg/kg, i.p., 21 days) of SSR149415 and SSR125543 reduced the FG 7142-induced increase in extracellular concentrations of acetylcholine in the hippocampus of anesthetized rats measured by microdialysis. By contrast acute and long-term administration of SSR149415 failed to reduce the FG 7142-induced increase in the release of norepinephrine in the cortex of freely moving rats. The present results demonstrate that the two compounds have similar profiles in a model of activation by an anxiogenic drug of the hippocampal cholinergic system and they suggest that SSR149415 and SSR125543 may have anti-stress anxiolytic and antidepressant effects via a mechanism of action different from classical benzodiazepine ligands and noradrenergic antidepressants.

Publication: Neuroscience 2006 Sep 1 ;141(3)::1481-8.
Publication Date: 2006 Sep 1
Study Author(s): Claustre, Y;Rouquier, L;Desvignes, C;Leonetti, M;Montégut, J;Aubin, N;Allouard, N;Bougault, I;Oury-Donat, F;Steinberg, R;
Institution: Sanofi-aventis B.P.110 92225 Bagneux Cedex, France. yves.clautre@sanofi-aventis.com
Shortcut link to this study:
Arginine vasopressin and corticotropin-releasing factor are two neuroactive peptides that regulate hypothalamic-pituitary-axis and associated stress response. While the potential antidepressant and anxiolytic profiles of corticotropin-releasing factor 1 antagonists have been well studied, the concept of blockade of vasopressin system as another approach for the treatment of emotional processes has only been made available recently by the synthesis of the first non-peptide antagonist at the V1b receptor, SSR149415. In the present study SSR149415 has been compared with the corticotropin-releasing factor 1 antagonist SSR125543 and with anxiolytic and antidepressant drugs on the response of hippocampal cholinergic and cortical noradrenergic systems to the anxiogenic benzodiazepine receptor inverse agonist FG 7142. Acute (0.3-10 mg/kg, i.p.) and long-term administration (10 mg/kg, i.p., 21 days) of SSR149415 and SSR125543 reduced the FG 7142-induced increase in extracellular concentrations of acetylcholine in the hippocampus of anesthetized rats measured by microdialysis. By contrast acute and long-term administration of SSR149415 failed to reduce the FG 7142-induced increase in the release of norepinephrine in the cortex of freely moving rats. The present results demonstrate that the two compounds have similar profiles in a model of activation by an anxiogenic drug of the hippocampal cholinergic system and they suggest that SSR149415 and SSR125543 may have anti-stress anxiolytic and antidepressant effects via a mechanism of action different from classical benzodiazepine ligands and noradrenergic antidepressants.
PMID: 16781820

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