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char = e;code = 101
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char = i;code = 105
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char = l;code = 108
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char = g;code = 103
char = r;code = 114
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char = f;code = 102
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char = y;code = 121
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char = o;code = 111
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char = a;code = 97
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char = i;code = 105
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char = d;code = 100
char = u;code = 117
char = c;code = 99
char = i;code = 105
char = n;code = 110
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char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
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char = 1;code = 49
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = ,;code = 44
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = x;code = 120
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = u;code = 117
char = r;code = 114
char = o;code = 111
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = -;code = 45
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
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char = p;code = 112
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
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char = t;code = 116
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char = r;code = 114
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char = a;code = 97
char = r;code = 114
char = e;code = 101
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char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
char = ;code = 32
char = m;code = 109
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char = d;code = 100
char = u;code = 117
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char = b;code = 98
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char = y;code = 121
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char = c;code = 99
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char = v;code = 118
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char = t;code = 116
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char = s;code = 115
char = u;code = 117
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char = p;code = 112
char = r;code = 114
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char = s;code = 115
char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
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char = ;code = 32
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char = d;code = 100
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char = n;code = 110
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char = e;code = 101
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char = ;code = 32
char = n;code = 110
char = o;code = 111
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char = e;code = 101
char = m;code = 109
char = o;code = 111
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char = t;code = 116
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char = d;code = 100
char = i;code = 105
char = e;code = 101
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char = r;code = 114
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char = >;code = 62
result sql = Despite advances in the understanding of prostate cancer (PCa) growth and development, it is still the leading incidence of cases and the second leading cause of mortality due to cancer in men. The problem of early diagnosis compounded with the emergence of androgen independence during commonly used anti-androgen therapy of PCa, have been discouraging for optimal therapeutic response. Recently, many chemopreventive agents, including silibinin, inositol hexaphosphate, decursin, apigenin, acacetin, grape seed extract, curcumin, and epigallocatechin-3 gallate have been identified in laboratory studies, which could be useful in the management of PCa. In vivo pre-clinical studies have indicated chemopreventive effect of many such agents in PCa xenograft and transgenic mouse models. The molecular targets of these agents include cell signaling, cell-cycle regulators, and survival/apoptotic molecules, which are implicated in uncontrolled PCa growth and progression. Furthermore, angiogenic and metastatic targets, including vascular endothelial growth factor, hypoxia-inducing factor-1alpha, matrix metalloproteinase, and urokinase-type plasminogen activator are also modulated by many chemopreventive agents to suppress the growth and invasive potential of PCa. This review focuses on novel PCa chemopreventive observations in laboratory studies, which could provide the rationale for the prospective use of chemopreventive agents in translational studies.
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char = m;code = 109
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char = i;code = 105
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char = n;code = 110
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char = o;code = 111
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char = l;code = 108
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char = a;code = 97
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = p;code = 112
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char = o;code = 111
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char = t;code = 116
char = a;code = 97
char = t;code = 116
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char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = h;code = 104
char = e;code = 101
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result sql = Mechanisms of action of novel agents for prostate cancer chemoprevention.
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
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char = ;code = 32
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char = a;code = 97
char = r;code = 114
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char = n;code = 110
char = o;code = 111
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char = s;code = 115
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char = c;code = 99
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char = m;code = 109
char = p;code = 112
char = o;code = 111
char = u;code = 117
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char = e;code = 101
char = d;code = 100
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = m;code = 109
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = f;code = 102
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = r;code = 114
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char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = d;code = 100
char = e;code = 101
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char = e;code = 101
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = d;code = 100
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = m;code = 109
char = o;code = 111
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char = l;code = 108
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char = u;code = 117
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = a;code = 97
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char = d;code = 100
char = r;code = 114
char = o;code = 111
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char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = y;code = 121
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char = ;code = 32
char = P;code = 80
char = C;code = 67
char = a;code = 97
char = ,;code = 44
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char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = b;code = 98
char = e;code = 101
char = e;code = 101
char = n;code = 110
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char = d;code = 100
char = i;code = 105
char = s;code = 115
char = c;code = 99
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char = u;code = 117
char = r;code = 114
char = a;code = 97
char = g;code = 103
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = t;code = 116
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char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = R;code = 82
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = ;code = 32
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = y;code = 121
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char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
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char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = x;code = 120
char = a;code = 97
char = p;code = 112
char = h;code = 104
char = o;code = 111
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = s;code = 115
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = i;code = 105
char = g;code = 103
char = e;code = 101
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
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char = s;code = 115
char = e;code = 101
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = e;code = 101
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = m;code = 109
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = e;code = 101
char = p;code = 112
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = i;code = 105
char = n;code = 110
char = -;code = 45
char = 3;code = 51
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char = g;code = 103
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = b;code = 98
char = e;code = 101
char = e;code = 101
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char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = l;code = 108
char = a;code = 97
char = b;code = 98
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = y;code = 121
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char = s;code = 115
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char = u;code = 117
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char = e;code = 101
char = s;code = 115
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char = w;code = 119
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char = i;code = 105
char = c;code = 99
char = h;code = 104
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char = c;code = 99
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char = l;code = 108
char = d;code = 100
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char = b;code = 98
char = e;code = 101
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char = s;code = 115
char = e;code = 101
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char = u;code = 117
char = l;code = 108
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
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char = m;code = 109
char = a;code = 97
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char = a;code = 97
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char = e;code = 101
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char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = P;code = 80
char = C;code = 67
char = a;code = 97
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = o;code = 111
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char = p;code = 112
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char = -;code = 45
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char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = s;code = 115
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char = u;code = 117
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char = i;code = 105
char = e;code = 101
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char = a;code = 97
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char = d;code = 100
char = i;code = 105
char = c;code = 99
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char = e;code = 101
char = d;code = 100
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char = c;code = 99
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char = e;code = 101
char = m;code = 109
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char = p;code = 112
char = r;code = 114
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char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = f;code = 102
char = ;code = 32
char = m;code = 109
char = a;code = 97
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char = y;code = 121
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char = s;code = 115
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char = c;code = 99
char = h;code = 104
char = ;code = 32
char = a;code = 97
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char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = P;code = 80
char = C;code = 67
char = a;code = 97
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char = x;code = 120
char = e;code = 101
char = n;code = 110
char = o;code = 111
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char = r;code = 114
char = a;code = 97
char = f;code = 102
char = t;code = 116
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char = a;code = 97
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char = r;code = 114
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char = s;code = 115
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char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = m;code = 109
char = o;code = 111
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char = s;code = 115
char = e;code = 101
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char = o;code = 111
char = d;code = 100
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = l;code = 108
char = e;code = 101
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char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = t;code = 116
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = i;code = 105
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = s;code = 115
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char = g;code = 103
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char = a;code = 97
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char = i;code = 105
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char = l;code = 108
char = l;code = 108
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = e;code = 101
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char = ;code = 32
char = P;code = 80
char = C;code = 67
char = a;code = 97
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char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = t;code = 116
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char = g;code = 103
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char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = F;code = 70
char = u;code = 117
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char = t;code = 116
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char = m;code = 109
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char = i;code = 105
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char = e;code = 101
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char = s;code = 115
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char = ;code = 32
char = i;code = 105
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char = c;code = 99
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char = a;code = 97
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char = a;code = 97
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char = o;code = 111
char = w;code = 119
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char = a;code = 97
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char = t;code = 116
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = h;code = 104
char = y;code = 121
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char = o;code = 111
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char = a;code = 97
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char = u;code = 117
char = c;code = 99
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char = g;code = 103
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char = f;code = 102
char = a;code = 97
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char = o;code = 111
char = r;code = 114
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char = p;code = 112
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char = a;code = 97
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char = a;code = 97
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char = r;code = 114
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char = m;code = 109
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = l;code = 108
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char = i;code = 105
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result sql = Despite advances in the understanding of prostate cancer (PCa) growth and development, it is still the leading incidence of cases and the second leading cause of mortality due to cancer in men. The problem of early diagnosis compounded with the emergence of androgen independence during commonly used anti-androgen therapy of PCa, have been discouraging for optimal therapeutic response. Recently, many chemopreventive agents, including silibinin, inositol hexaphosphate, decursin, apigenin, acacetin, grape seed extract, curcumin, and epigallocatechin-3 gallate have been identified in laboratory studies, which could be useful in the management of PCa. In vivo pre-clinical studies have indicated chemopreventive effect of many such agents in PCa xenograft and transgenic mouse models. The molecular targets of these agents include cell signaling, cell-cycle regulators, and survival/apoptotic molecules, which are implicated in uncontrolled PCa growth and progression. Furthermore, angiogenic and metastatic targets, including vascular endothelial growth factor, hypoxia-inducing factor-1alpha, matrix metalloproteinase, and urokinase-type plasminogen activator are also modulated by many chemopreventive agents to suppress the growth and invasive potential of PCa. This review focuses on novel PCa chemopreventive observations in laboratory studies, which could provide the rationale for the prospective use of chemopreventive agents in translational studies.
Publication: Endocr. Relat. Cancer 2006 Sep ;13(3)::751-78.
Publication Date: 2006 Sep
Study Author(s): Singh, Rana P;Agarwal, Rajesh;
Institution: Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Cancer Center, Denver 80262, USA.
Shortcut link to this study:
Publication Date: 2006 Sep
Study Author(s): Singh, Rana P;Agarwal, Rajesh;
Institution: Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Cancer Center, Denver 80262, USA.
Shortcut link to this study:
Despite advances in the understanding of prostate cancer (PCa) growth and development, it is still the leading incidence of cases and the second leading cause of mortality due to cancer in men. The problem of early diagnosis compounded with the emergence of androgen independence during commonly used anti-androgen therapy of PCa, have been discouraging for optimal therapeutic response. Recently, many chemopreventive agents, including silibinin, inositol hexaphosphate, decursin, apigenin, acacetin, grape seed extract, curcumin, and epigallocatechin-3 gallate have been identified in laboratory studies, which could be useful in the management of PCa. In vivo pre-clinical studies have indicated chemopreventive effect of many such agents in PCa xenograft and transgenic mouse models. The molecular targets of these agents include cell signaling, cell-cycle regulators, and survival/apoptotic molecules, which are implicated in uncontrolled PCa growth and progression. Furthermore, angiogenic and metastatic targets, including vascular endothelial growth factor, hypoxia-inducing factor-1alpha, matrix metalloproteinase, and urokinase-type plasminogen activator are also modulated by many chemopreventive agents to suppress the growth and invasive potential of PCa. This review focuses on novel PCa chemopreventive observations in laboratory studies, which could provide the rationale for the prospective use of chemopreventive agents in translational studies.
PMID: 16954429
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