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char = o;code = 111
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char = t;code = 116
char = i;code = 105
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char = o;code = 111
char = f;code = 102
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char = s;code = 115
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char = e;code = 101
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char = t;code = 116
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = .;code = 46
result sql = Mechanical properties and compositions of tissue engineered and native arteries.
Mechanical properties and compositions of tissue engineered and native arteries.
char = W;code = 87
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = g;code = 103
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
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char = c;code = 99
char = a;code = 97
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char = ;code = 32
char = p;code = 112
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char = o;code = 111
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = t;code = 116
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char = e;code = 101
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = g;code = 103
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = ;code = 32
char = n;code = 110
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char = t;code = 116
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char = v;code = 118
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char = t;code = 116
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char = s;code = 115
char = s;code = 115
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char = e;code = 101
char = ,;code = 44
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char = s;code = 115
char = s;code = 115
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char = e;code = 101
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char = s;code = 115
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char = e;code = 101
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char = o;code = 111
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char = c;code = 99
char = u;code = 117
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char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = r;code = 114
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char = p;code = 112
char = l;code = 108
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = m;code = 109
char = e;code = 101
char = n;code = 110
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char = ;code = 32
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = s;code = 115
char = u;code = 117
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = n;code = 110
char = a;code = 97
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char = i;code = 105
char = v;code = 118
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char = i;code = 105
char = s;code = 115
char = s;code = 115
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char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = I;code = 73
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = r;code = 114
char = e;code = 101
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char = o;code = 111
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char = t;code = 116
char = ,;code = 44
char = ;code = 32
char = d;code = 100
char = i;code = 105
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char = f;code = 102
char = e;code = 101
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char = s;code = 115
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char = e;code = 101
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char = ;code = 32
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char = d;code = 100
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char = r;code = 114
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char = d;code = 100
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char = n;code = 110
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char = e;code = 101
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char = a;code = 97
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char = t;code = 116
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = r;code = 114
char = r;code = 114
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char = l;code = 108
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = s;code = 115
char = u;code = 117
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = E;code = 69
char = n;code = 110
char = g;code = 103
char = i;code = 105
char = n;code = 110
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char = e;code = 101
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char = a;code = 97
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char = e;code = 101
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char = f;code = 102
char = a;code = 97
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char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = m;code = 109
char = a;code = 97
char = t;code = 116
char = c;code = 99
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = s;code = 115
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char = r;code = 114
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char = g;code = 103
char = t;code = 116
char = h;code = 104
char = s;code = 115
char = ;code = 32
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char = r;code = 114
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = i;code = 105
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = s;code = 115
char = s;code = 115
char = u;code = 117
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = L;code = 76
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char = e;code = 101
char = r;code = 114
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char = s;code = 115
char = t;code = 116
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char = e;code = 101
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char = g;code = 103
char = t;code = 116
char = h;code = 104
char = s;code = 115
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char = o;code = 111
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char = e;code = 101
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char = i;code = 105
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char = e;code = 101
char = e;code = 101
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char = d;code = 100
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char = a;code = 97
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char = t;code = 116
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = e;code = 101
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char = ;code = 32
char = r;code = 114
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char = l;code = 108
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char = r;code = 114
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char = c;code = 99
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char = i;code = 105
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char = a;code = 97
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char = p;code = 112
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char = d;code = 100
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char = m;code = 109
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char = f;code = 102
char = r;code = 114
char = a;code = 97
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char = e;code = 101
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result sql = With the goal of mimicking the mechanical properties of a given native tissue, tissue engineers seek to culture replacement tissues with compositions similar to those of native tissues. In this report, differences between the mechanical properties of engineered arteries and native arteries were correlated with differences in tissue composition. Engineered arteries failed to match the strengths or compliances of native tissues. Lower strengths of engineered arteries resulted partially from inferior organization of collagen, but not from differences in collagen density. Furthermore, ultimate strengths of engineered vessels were significantly reduced by the presence of residual polyglycolic acid polymer fragments, which caused stress concentrations in the vessel wall. Lower compliances of engineered vessels resulted from minimal smooth muscle cell contractility and a lack of organized extracellular elastin. Organization of elastin and collagen in engineered arteries may have been partially hindered by high concentrations of sulfated glycosaminoglycans. Tissue engineers should continue to regulate cell phenotype and promote synthesis of proteins that are known to dominate the mechanical properties of the associated native tissue. However, we should also be aware of the potential negative impacts of polymer fragments and glycosaminoglycans on the mechanical properties of engineered tissues.

Publication: Ann Biomed Eng 2007 Mar ;35(3)::348-55.
Publication Date: 2007 Mar
Study Author(s): Dahl, Shannon L M;Rhim, Caroline;Song, Ying C;Niklason, Laura E;
Institution: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. [email protected]
Shortcut link to this study:
With the goal of mimicking the mechanical properties of a given native tissue, tissue engineers seek to culture replacement tissues with compositions similar to those of native tissues. In this report, differences between the mechanical properties of engineered arteries and native arteries were correlated with differences in tissue composition. Engineered arteries failed to match the strengths or compliances of native tissues. Lower strengths of engineered arteries resulted partially from inferior organization of collagen, but not from differences in collagen density. Furthermore, ultimate strengths of engineered vessels were significantly reduced by the presence of residual polyglycolic acid polymer fragments, which caused stress concentrations in the vessel wall. Lower compliances of engineered vessels resulted from minimal smooth muscle cell contractility and a lack of organized extracellular elastin. Organization of elastin and collagen in engineered arteries may have been partially hindered by high concentrations of sulfated glycosaminoglycans. Tissue engineers should continue to regulate cell phenotype and promote synthesis of proteins that are known to dominate the mechanical properties of the associated native tissue. However, we should also be aware of the potential negative impacts of polymer fragments and glycosaminoglycans on the mechanical properties of engineered tissues.
PMID: 17206488

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