char = B;code = 66 char = i;code = 105 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = o;code = 111 char = t;code = 116 char = o;code = 111 char = m;code = 109 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = e;code = 101 char = s;code = 115 char = e;code = 101 char = l;code = 108 char = -;code = 45 char = s;code = 115 char = o;code = 111 char = o;code = 111 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = f;code = 102 char = l;code = 108 char = a;code = 97 char = m;code = 109 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = .;code = 46 result sql = Bilateral vagotomy or atropine pre-treatment reduces experimental diesel-soot induced lung inflammation.
Bilateral vagotomy or atropine pre-treatment reduces experimental diesel-soot induced lung inflammation.char = T;code = 84 char = o;code = 111 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = v;code = 118 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = g;code = 103 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = n;code = 110 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = u;code = 117 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = f;code = 102 char = l;code = 108 char = a;code = 97 char = m;code = 109 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = c;code = 99 char = a;code = 97 char = r;code = 114 char = d;code = 100 char = i;code = 105 char = o;code = 111 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = p;code = 112 char = i;code = 105 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = p;code = 112 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = e;code = 101 char = s;code = 115 char = e;code = 101 char = l;code = 108 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = D;code = 68 char = P;code = 80 char = );code = 41 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = i;code = 105 char = r;code = 114 char = w;code = 119 char = a;code = 97 char = y;code = 121 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = c;code = 99 char = h;code = 104 char = a;code = 97 char = n;code = 110 char = g;code = 103 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = p;code = 112 char = i;code = 105 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ,;code = 44 char = ;code = 32 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = o;code = 111 char = d;code = 100 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = n;code = 110 char = e;code = 101 char = u;code = 117 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = h;code = 104 char = i;code = 105 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = n;code = 110 char = g;code = 103 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = t;code = 116 char = i;code = 105 char = z;code = 122 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = W;code = 87 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = 6;code = 54 char = -;code = 45 char = h;code = 104 char = ;code = 32 char = p;code = 112 char = o;code = 111 char = s;code = 115 char = t;code = 116 char = -;code = 45 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = l;code = 108 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = ;code = 32 char = (;code = 40 char = 5;code = 53 char = 0;code = 48 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = c;code = 99 char = r;code = 114 char = o;code = 111 char = g;code = 103 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = i;code = 105 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = d;code = 100 char = -;code = 45 char = c;code = 99 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = o;code = 111 char = t;code = 116 char = o;code = 111 char = m;code = 109 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = ;code = 32 char = m;code = 109 char = g;code = 103 char = ;code = 32 char = k;code = 107 char = g;code = 103 char = (;code = 40 char = -;code = 45 char = 1;code = 49 char = );code = 41 char = );code = 41 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = c;code = 99 char = i;code = 105 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = v;code = 118 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = g;code = 103 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = o;code = 111 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = .;code = 46 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = n;code = 110 char = e;code = 101 char = u;code = 117 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = h;code = 104 char = i;code = 105 char = l;code = 108 char = ;code = 32 char = l;code = 108 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = l;code = 108 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = B;code = 66 char = A;code = 65 char = L;code = 76 char = ;code = 32 char = (;code = 40 char = b;code = 98 char = r;code = 114 char = o;code = 111 char = n;code = 110 char = c;code = 99 char = h;code = 104 char = o;code = 111 char = a;code = 97 char = l;code = 108 char = v;code = 118 char = e;code = 101 char = o;code = 111 char = l;code = 108 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = l;code = 108 char = a;code = 97 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = e;code = 101 char = );code = 41 char = ;code = 32 char = f;code = 102 char = l;code = 108 char = u;code = 117 char = i;code = 105 char = d;code = 100 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = t;code = 116 char = i;code = 105 char = z;code = 122 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = 2;code = 50 char = .;code = 46 char = 5;code = 53 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = 0;code = 48 char = .;code = 46 char = 7;code = 55 char = x;code = 120 char = 1;code = 49 char = 0;code = 48 char = (;code = 40 char = 6;code = 54 char = );code = 41 char = ;code = 32 char = c;code = 99 char = e;code = 101 char = l;code = 108 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = =;code = 61 char = 8;code = 56 char = );code = 41 char = ,;code = 44 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = i;code = 105 char = l;code = 108 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = (;code = 40 char = 0;code = 48 char = .;code = 46 char = 3;code = 51 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = 0;code = 48 char = .;code = 46 char = 1;code = 49 char = x;code = 120 char = 1;code = 49 char = 0;code = 48 char = (;code = 40 char = 6;code = 54 char = );code = 41 char = ,;code = 44 char = ;code = 32 char = n;code = 110 char = =;code = 61 char = 7;code = 55 char = ;;code = 59 char = ;code = 32 char = P;code = 80 char = <;code = 60 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = );code = 41 char = .;code = 46 char = ;code = 32 char = V;code = 86 char = a;code = 97 char = g;code = 103 char = o;code = 111 char = t;code = 116 char = o;code = 111 char = m;code = 109 char = y;code = 121 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = ;code = 32 char = n;code = 110 char = e;code = 101 char = u;code = 117 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = h;code = 104 char = i;code = 105 char = l;code = 108 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 8;code = 56 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = 0;code = 48 char = .;code = 46 char = 2;code = 50 char = x;code = 120 char = 1;code = 49 char = 0;code = 48 char = (;code = 40 char = 6;code = 54 char = );code = 41 char = ;code = 32 char = c;code = 99 char = e;code = 101 char = l;code = 108 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = =;code = 61 char = 8;code = 56 char = ;;code = 59 char = ;code = 32 char = P;code = 80 char = <;code = 60 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = ;code = 32 char = v;code = 118 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = );code = 41 char = ;;code = 59 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = -;code = 45 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = n;code = 110 char = e;code = 101 char = u;code = 117 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = h;code = 104 char = i;code = 105 char = l;code = 108 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 3;code = 51 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = 0;code = 48 char = .;code = 46 char = 2;code = 50 char = x;code = 120 char = 1;code = 49 char = 0;code = 48 char = (;code = 40 char = 6;code = 54 char = );code = 41 char = ;code = 32 char = (;code = 40 char = n;code = 110 char = =;code = 61 char = 4;code = 52 char = ;;code = 59 char = ;code = 32 char = P;code = 80 char = <;code = 60 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = );code = 41 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = c;code = 99 char = i;code = 105 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = ;code = 32 char = n;code = 110 char = e;code = 101 char = u;code = 117 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = h;code = 104 char = i;code = 105 char = l;code = 108 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = 8;code = 56 char = .;code = 46 char = 5;code = 53 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = 1;code = 49 char = .;code = 46 char = 8;code = 56 char = x;code = 120 char = 1;code = 49 char = 0;code = 48 char = (;code = 40 char = 6;code = 54 char = );code = 41 char = ,;code = 44 char = ;code = 32 char = n;code = 110 char = =;code = 61 char = 4;code = 52 char = ,;code = 44 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = 2;code = 50 char = .;code = 46 char = 2;code = 50 char = +;code = 43 char = /;code = 47 char = -;code = 45 char = 1;code = 49 char = .;code = 46 char = 2;code = 50 char = x;code = 120 char = 1;code = 49 char = 0;code = 48 char = (;code = 40 char = 6;code = 54 char = );code = 41 char = ;code = 32 char = c;code = 99 char = e;code = 101 char = l;code = 108 char = l;code = 108 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = n;code = 110 char = =;code = 61 char = 3;code = 51 char = .;code = 46 char = ;code = 32 char = H;code = 72 char = y;code = 121 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = v;code = 118 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = c;code = 99 char = c;code = 99 char = u;code = 117 char = r;code = 114 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = 6;code = 54 char = ;code = 32 char = h;code = 104 char = ;code = 32 char = a;code = 97 char = f;code = 102 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = t;code = 116 char = i;code = 105 char = z;code = 122 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = i;code = 105 char = ,;code = 44 char = ;code = 32 char = b;code = 98 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = b;code = 98 char = i;code = 105 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = l;code = 108 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = o;code = 111 char = t;code = 116 char = o;code = 111 char = m;code = 109 char = i;code = 105 char = z;code = 122 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = -;code = 45 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = b;code = 98 char = o;code = 111 char = l;code = 108 char = i;code = 105 char = s;code = 115 char = h;code = 104 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = o;code = 111 char = t;code = 116 char = o;code = 111 char = m;code = 109 char = y;code = 121 char = ;code = 32 char = (;code = 40 char = P;code = 80 char = <;code = 60 char = 0;code = 48 char = .;code = 46 char = 0;code = 48 char = 5;code = 53 char = ,;code = 44 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = i;code = 105 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = );code = 41 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = ;code = 32 char = s;code = 115 char = i;code = 105 char = g;code = 103 char = n;code = 110 char = i;code = 105 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = r;code = 114 char = i;code = 105 char = a;code = 97 char = b;code = 98 char = l;code = 108 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = m;code = 109 char = e;code = 101 char = a;code = 97 char = n;code = 110 char = ;code = 32 char = b;code = 98 char = l;code = 108 char = o;code = 111 char = o;code = 111 char = d;code = 100 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = ,;code = 44 char = ;code = 32 char = h;code = 104 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = t;code = 116 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = h;code = 104 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = t;code = 116 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = r;code = 114 char = i;code = 105 char = a;code = 97 char = b;code = 98 char = i;code = 105 char = l;code = 108 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = );code = 41 char = ;code = 32 char = m;code = 109 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = 3;code = 51 char = 6;code = 54 char = 0;code = 48 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = f;code = 102 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = c;code = 99 char = l;code = 108 char = u;code = 117 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ,;code = 44 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = -;code = 45 char = i;code = 105 char = n;code = 110 char = f;code = 102 char = l;code = 108 char = a;code = 97 char = m;code = 109 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = o;code = 111 char = -;code = 45 char = v;code = 118 char = a;code = 97 char = g;code = 103 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = f;code = 102 char = l;code = 108 char = e;code = 101 char = x;code = 120 char = ;code = 32 char = w;code = 119 char = h;code = 104 char = i;code = 105 char = c;code = 99 char = h;code = 104 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = .;code = 46 char = ;code = 32 char = M;code = 77 char = u;code = 117 char = s;code = 115 char = c;code = 99 char = a;code = 97 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = A;code = 65 char = C;code = 67 char = h;code = 104 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = p;code = 112 char = t;code = 116 char = o;code = 111 char = r;code = 114 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = l;code = 108 char = u;code = 117 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = v;code = 118 char = o;code = 111 char = l;code = 108 char = v;code = 118 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = -;code = 45 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = n;code = 110 char = e;code = 101 char = u;code = 117 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = h;code = 104 char = i;code = 105 char = l;code = 108 char = i;code = 105 char = a;code = 97 char = ,;code = 44 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = h;code = 104 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = u;code = 117 char = s;code = 115 char = c;code = 99 char = a;code = 97 char = r;code = 114 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = g;code = 103 char = o;code = 111 char = n;code = 110 char = i;code = 105 char = s;code = 115 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = i;code = 105 char = r;code = 114 char = w;code = 119 char = a;code = 97 char = y;code = 121 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = /;code = 47 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = c;code = 99 char = a;code = 97 char = r;code = 114 char = d;code = 100 char = i;code = 105 char = o;code = 111 char = v;code = 118 char = a;code = 97 char = s;code = 115 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = r;code = 114 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = f;code = 102 char = l;code = 108 char = a;code = 97 char = m;code = 109 char = m;code = 109 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = o;code = 111 char = k;code = 107 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = b;code = 98 char = y;code = 121 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = h;code = 104 char = a;code = 97 char = l;code = 108 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = o;code = 111 char = s;code = 115 char = p;code = 112 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = ;code = 32 char = D;code = 68 char = P;code = 80 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = s;code = 115 char = c;code = 99 char = e;code = 101 char = p;code = 112 char = t;code = 116 char = i;code = 105 char = b;code = 98 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = d;code = 100 char = u;code = 117 char = a;code = 97 char = l;code = 108 char = s;code = 115 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 result sql = To investigate the role of the vagus nerve in acute inflammatory and cardiorespiratory responses to diesel particulate (DP) in the rat airway, we measured changes in respiration, blood pressure and neutrophils in lungs of urethane anesthetized Wistar rats 6-h post-instillation of DP (500 microg) and studied the effect of mid-cervical vagotomy or atropine (1 mg kg(-1)) pre-treatment. In conscious rats, we investigated DP, with and without atropine pre-treatment. DP increased neutrophil level in BAL (bronchoalveolar lavage) fluid from intact anesthetized rats to 2.5+/-0.7x10(6) cells (n=8), compared with saline instillation (0.3+/-0.1x10(6), n=7; P<0.05). Vagotomy reduced DP neutrophilia to 0.8+/-0.2x10(6) cells (n=8; P<0.05 vs. intact); atropine reduced DP-induced neutrophilia to 0.3+/-0.2x10(6) (n=4; P<0.05). In conscious rats, DP neutrophilia of 8.5+/-1.8x10(6), n=4, was reduced by pre-treatment with atropine to 2.2+/-1.2x10(6) cells, n=3. Hyperventilation occurred 6 h after DP in anesthetized rats with intact vagi, but not in bilaterally vagotomized or atropine pre-treated animals and was abolished by vagotomy (P<0.05, paired test). There were no significant differences in the other variables (mean blood pressure, heart rate and heart rate variability) measured before and 360 min after DP. In conclusion, DP activates a pro-inflammatory vago-vagal reflex which is reduced by atropine. Muscarinic ACh receptors in the rat lung are involved in DP-induced neutrophilia, and hence muscarinic antagonists may reduce airway and/or cardiovascular inflammation evoked by inhaled atmospheric DP in susceptible individuals.
Publication: Toxicol. Appl. Pharmacol. 2007 Feb 15 ;219(1)::62-71.
Publication Date: 2007 Feb 15
Study Author(s): McQueen, D S;Donaldson, K;Bond, S M;McNeilly, J D;Newman, S;Barton, N J;Duffin, R;
Institution: University of Edinburgh, School of Biomedical Sciences, 1 George Square, Edinburgh EH8 9JZ, Scotland, UK.
[email protected]
Shortcut link to this study:
To investigate the role of the vagus nerve in acute inflammatory and cardiorespiratory responses to diesel particulate (DP) in the rat airway, we measured changes in respiration, blood pressure and neutrophils in lungs of urethane anesthetized Wistar rats 6-h post-instillation of DP (500 microg) and studied the effect of mid-cervical vagotomy or atropine (1 mg kg(-1)) pre-treatment. In conscious rats, we investigated DP, with and without atropine pre-treatment. DP increased neutrophil level in BAL (bronchoalveolar lavage) fluid from intact anesthetized rats to 2.5+/-0.7x10(6) cells (n=8), compared with saline instillation (0.3+/-0.1x10(6), n=7; P<0.05). Vagotomy reduced DP neutrophilia to 0.8+/-0.2x10(6) cells (n=8; P<0.05 vs. intact); atropine reduced DP-induced neutrophilia to 0.3+/-0.2x10(6) (n=4; P<0.05). In conscious rats, DP neutrophilia of 8.5+/-1.8x10(6), n=4, was reduced by pre-treatment with atropine to 2.2+/-1.2x10(6) cells, n=3. Hyperventilation occurred 6 h after DP in anesthetized rats with intact vagi, but not in bilaterally vagotomized or atropine pre-treated animals and was abolished by vagotomy (P<0.05, paired test). There were no significant differences in the other variables (mean blood pressure, heart rate and heart rate variability) measured before and 360 min after DP. In conclusion, DP activates a pro-inflammatory vago-vagal reflex which is reduced by atropine. Muscarinic ACh receptors in the rat lung are involved in DP-induced neutrophilia, and hence muscarinic antagonists may reduce airway and/or cardiovascular inflammation evoked by inhaled atmospheric DP in susceptible individuals.
PMID: 17239416