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= /;code = 47 char = >;code = 62 result sql = This paper reviews the rationale for developing a tissue-engineered aortic valve by building up the complex microstructure from its basic components, and presents recent progress towards that goal. Over the past 4 years, we have been working on engineering the functional components of the composite valve the collagen fiber bundles, the elastin sheets, and the hyaluronan matrix that keeps the tissue hydrated. Most recently, we have been working on optimizing the geometry and material properties of the collagen constructs, by varying their size and aspect ratio, and the types of loading protocols the constructs experience during the culture process.
Publication: Conf Proc IEEE Eng Med Biol Soc 2005 ;3:2979-80.
Publication Date: 2005
Study Author(s): Bhatia, A;Vesely, I;
Institution: Dept.of Cardiothoracic Surgery,University of Southern California, and The Childrens Hospital Los Angeles, 4650 Sunset Blvd., Los Angeles,CA 90027.
Shortcut link to this study:
This paper reviews the rationale for developing a tissue-engineered aortic valve by building up the complex microstructure from its basic components, and presents recent progress towards that goal. Over the past 4 years, we have been working on engineering the functional components of the composite valve the collagen fiber bundles, the elastin sheets, and the hyaluronan matrix that keeps the tissue hydrated. Most recently, we have been working on optimizing the geometry and material properties of the collagen constructs, by varying their size and aspect ratio, and the types of loading protocols the constructs experience during the culture process.
PMID: 17282868