|
|
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result sql = In vitro effect of pesticides (dichlofluanid, endosulfan, simazine, tolylfluanid and triallate) on proliferative activity of animal derived cell cultures.
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char = ;code = 32
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = l;code = 108
char = o;code = 111
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 3;code = 51
char = .;code = 46
char = 9;code = 57
char = 4;code = 52
char = );code = 41
char = ;code = 32
char = M;code = 77
char = );code = 41
char = ;code = 32
char = >;code = 62
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = l;code = 108
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 3;code = 51
char = .;code = 46
char = 6;code = 54
char = 9;code = 57
char = );code = 41
char = ;code = 32
char = M;code = 77
char = );code = 41
char = ;code = 32
char = >;code = 62
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = o;code = 111
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = f;code = 102
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 3;code = 51
char = .;code = 46
char = 2;code = 50
char = 4;code = 52
char = );code = 41
char = ;code = 32
char = M;code = 77
char = );code = 41
char = ;code = 32
char = >;code = 62
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 3;code = 51
char = .;code = 46
char = 1;code = 49
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = M;code = 77
char = );code = 41
char = ;code = 32
char = >;code = 62
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = z;code = 122
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 1;code = 49
char = .;code = 46
char = 7;code = 55
char = 8;code = 56
char = );code = 41
char = ;code = 32
char = M;code = 77
char = );code = 41
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = a;code = 97
char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = P;code = 80
char = K;code = 75
char = 1;code = 49
char = 5;code = 53
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 3;code = 51
char = .;code = 46
char = 2;code = 50
char = 7;code = 55
char = );code = 41
char = ;code = 32
char = M;code = 77
char = );code = 41
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = R;code = 82
char = K;code = 75
char = 1;code = 49
char = 3;code = 51
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 3;code = 51
char = .;code = 46
char = 2;code = 50
char = 1;code = 49
char = );code = 41
char = ;code = 32
char = M;code = 77
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = M;code = 77
char = D;code = 68
char = B;code = 66
char = K;code = 75
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 2;code = 50
char = .;code = 46
char = 5;code = 53
char = 5;code = 53
char = );code = 41
char = ;code = 32
char = M;code = 77
char = );code = 41
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = B;code = 66
char = E;code = 69
char = P;code = 80
char = C;code = 67
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 2;code = 50
char = .;code = 46
char = 5;code = 53
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = M;code = 77
char = );code = 41
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = In this study pesticides with different chemical structures (dichlofluanid, endosulfan, simazine, tolylfluanid and triallate) were examined for their potential cytotoxic effect on proliferative activity of cell cultures of mammalian origin. Cell lines Madin-Darby Bovine Kidney (MDBK), Rabbit Kidney (RK13), Porcine Kidney (PK15), and semicontinual line of Bovine Embryonic Pulmonary Cells (BEPC) were used in the study. From these cell cultures cell proliferative activity was suppressed most intensively in PK15 culture by endosulfan (10(-1) - 10(-6) M). The least effect on cell proliferation in all cell cultures tested, with the exception PK 15 (10(-1) - 10(-2) M), was recorded after simazine exposure. On the basis of IC50 values the cytotoxic effect was: dichlofluanid (IC50 = 10(-3.94) M) > tolylfluanid (IC50 = 10(-3.69) M) > endosulfan (IC50 = 10(-3.24) M) > triallate (IC50 = 10(-3.12) M) > simazine (IC50 = 10(-1.78) M). The comparison of average IC50 values of cell cultures revealed that the most sensitive cell lines were PK15 (IC50 = 10(-3.27) M) and RK13 (IC50 = 10(-3.21) M), whereas MDBK (IC50 = 10(-2.55) M) and BEPC (IC50 = 10(-2.52) M) were less sensitive to pesticide exposure.
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = l;code = 108
char = o;code = 111
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = d;code = 100
char = ,;code = 44
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = o;code = 111
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = f;code = 102
char = a;code = 97
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = z;code = 122
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = l;code = 108
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = );code = 41
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = .;code = 46
result sql = In vitro effect of pesticides (dichlofluanid, endosulfan, simazine, tolylfluanid and triallate) on proliferative activity of animal derived cell cultures.
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = l;code = 108
char = o;code = 111
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = d;code = 100
char = ,;code = 44
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = o;code = 111
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = f;code = 102
char = a;code = 97
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = z;code = 122
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = l;code = 108
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = );code = 41
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = i;code = 105
char = r;code = 114
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = i;code = 105
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = i;code = 105
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = M;code = 77
char = a;code = 97
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = -;code = 45
char = D;code = 68
char = a;code = 97
char = r;code = 114
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = B;code = 66
char = o;code = 111
char = v;code = 118
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = K;code = 75
char = i;code = 105
char = d;code = 100
char = n;code = 110
char = e;code = 101
char = y;code = 121
char = ;code = 32
char = (;code = 40
char = M;code = 77
char = D;code = 68
char = B;code = 66
char = K;code = 75
char = );code = 41
char = ,;code = 44
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char = b;code = 98
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char = n;code = 110
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char = a;code = 97
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char = l;code = 108
char = i;code = 105
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char = E;code = 69
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char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = (;code = 40
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char = P;code = 80
char = C;code = 67
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char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = u;code = 117
char = s;code = 115
char = e;code = 101
char = d;code = 100
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char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = s;code = 115
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char = .;code = 46
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char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = v;code = 118
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char = t;code = 116
char = i;code = 105
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char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = p;code = 112
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char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = m;code = 109
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char = s;code = 115
char = t;code = 116
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char = n;code = 110
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char = e;code = 101
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char = s;code = 115
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char = v;code = 118
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = P;code = 80
char = K;code = 75
char = 1;code = 49
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char = c;code = 99
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char = t;code = 116
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char = r;code = 114
char = e;code = 101
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char = b;code = 98
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char = e;code = 101
char = n;code = 110
char = d;code = 100
char = o;code = 111
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char = u;code = 117
char = l;code = 108
char = f;code = 102
char = a;code = 97
char = n;code = 110
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char = 1;code = 49
char = 0;code = 48
char = (;code = 40
char = -;code = 45
char = 1;code = 49
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char = ;code = 32
char = -;code = 45
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char = 1;code = 49
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char = .;code = 46
char = ;code = 32
char = T;code = 84
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char = l;code = 108
char = e;code = 101
char = a;code = 97
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char = f;code = 102
char = e;code = 101
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
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char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = i;code = 105
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char = i;code = 105
char = n;code = 110
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char = a;code = 97
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char = l;code = 108
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = t;code = 116
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char = s;code = 115
char = t;code = 116
char = e;code = 101
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char = t;code = 116
char = h;code = 104
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = P;code = 80
char = K;code = 75
char = ;code = 32
char = 1;code = 49
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char = (;code = 40
char = 1;code = 49
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char = 1;code = 49
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char = ;code = 32
char = -;code = 45
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char = 1;code = 49
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char = t;code = 116
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char = s;code = 115
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char = f;code = 102
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char = I;code = 73
char = C;code = 67
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char = I;code = 73
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char = ;code = 32
char = =;code = 61
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char = 1;code = 49
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char = -;code = 45
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char = 9;code = 57
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char = a;code = 97
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char = I;code = 73
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char = ;code = 32
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char = 1;code = 49
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char = a;code = 97
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char = I;code = 73
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char = l;code = 108
char = a;code = 97
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char = I;code = 73
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char = 5;code = 53
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char = ;code = 32
char = =;code = 61
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char = 1;code = 49
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char = -;code = 45
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char = 1;code = 49
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char = a;code = 97
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char = i;code = 105
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char = I;code = 73
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char = 5;code = 53
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char = ;code = 32
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char = 1;code = 49
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char = 1;code = 49
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char = 7;code = 55
char = 8;code = 56
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char = ;code = 32
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
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char = a;code = 97
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char = i;code = 105
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char = e;code = 101
char = r;code = 114
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char = g;code = 103
char = e;code = 101
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char = I;code = 73
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char = r;code = 114
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char = a;code = 97
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char = t;code = 116
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char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = P;code = 80
char = K;code = 75
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char = (;code = 40
char = I;code = 73
char = C;code = 67
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char = ;code = 32
char = =;code = 61
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char = 1;code = 49
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char = a;code = 97
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char = R;code = 82
char = K;code = 75
char = 1;code = 49
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char = (;code = 40
char = I;code = 73
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char = a;code = 97
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char = B;code = 66
char = K;code = 75
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char = (;code = 40
char = I;code = 73
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char = B;code = 66
char = E;code = 69
char = P;code = 80
char = C;code = 67
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char = (;code = 40
char = I;code = 73
char = C;code = 67
char = 5;code = 53
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char = ;code = 32
char = =;code = 61
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char = 1;code = 49
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char = (;code = 40
char = -;code = 45
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char = .;code = 46
char = 5;code = 53
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char = w;code = 119
char = e;code = 101
char = r;code = 114
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char = ;code = 32
char = l;code = 108
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char = s;code = 115
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char = s;code = 115
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char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = t;code = 116
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char = p;code = 112
char = e;code = 101
char = s;code = 115
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char = i;code = 105
char = c;code = 99
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char = d;code = 100
char = e;code = 101
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char = e;code = 101
char = x;code = 120
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = In this study pesticides with different chemical structures (dichlofluanid, endosulfan, simazine, tolylfluanid and triallate) were examined for their potential cytotoxic effect on proliferative activity of cell cultures of mammalian origin. Cell lines Madin-Darby Bovine Kidney (MDBK), Rabbit Kidney (RK13), Porcine Kidney (PK15), and semicontinual line of Bovine Embryonic Pulmonary Cells (BEPC) were used in the study. From these cell cultures cell proliferative activity was suppressed most intensively in PK15 culture by endosulfan (10(-1) - 10(-6) M). The least effect on cell proliferation in all cell cultures tested, with the exception PK 15 (10(-1) - 10(-2) M), was recorded after simazine exposure. On the basis of IC50 values the cytotoxic effect was: dichlofluanid (IC50 = 10(-3.94) M) > tolylfluanid (IC50 = 10(-3.69) M) > endosulfan (IC50 = 10(-3.24) M) > triallate (IC50 = 10(-3.12) M) > simazine (IC50 = 10(-1.78) M). The comparison of average IC50 values of cell cultures revealed that the most sensitive cell lines were PK15 (IC50 = 10(-3.27) M) and RK13 (IC50 = 10(-3.21) M), whereas MDBK (IC50 = 10(-2.55) M) and BEPC (IC50 = 10(-2.52) M) were less sensitive to pesticide exposure.
Publication: Acta. Biol. Hung. 2007 Mar ;58(1)::61-74.
Publication Date: 2007 Mar
Study Author(s): Holovská, Vanda;Pistl, J;Kovalkovicová, Natália;
Institution: Faculty of Medicine, University of P. J. Safarik, Trieda SNP 1, 040 01 Kosice.
Shortcut link to this study:
Publication Date: 2007 Mar
Study Author(s): Holovská, Vanda;Pistl, J;Kovalkovicová, Natália;
Institution: Faculty of Medicine, University of P. J. Safarik, Trieda SNP 1, 040 01 Kosice.
Shortcut link to this study:
In this study pesticides with different chemical structures (dichlofluanid, endosulfan, simazine, tolylfluanid and triallate) were examined for their potential cytotoxic effect on proliferative activity of cell cultures of mammalian origin. Cell lines Madin-Darby Bovine Kidney (MDBK), Rabbit Kidney (RK13), Porcine Kidney (PK15), and semicontinual line of Bovine Embryonic Pulmonary Cells (BEPC) were used in the study. From these cell cultures cell proliferative activity was suppressed most intensively in PK15 culture by endosulfan (10(-1) - 10(-6) M). The least effect on cell proliferation in all cell cultures tested, with the exception PK 15 (10(-1) - 10(-2) M), was recorded after simazine exposure. On the basis of IC50 values the cytotoxic effect was: dichlofluanid (IC50 = 10(-3.94) M) > tolylfluanid (IC50 = 10(-3.69) M) > endosulfan (IC50 = 10(-3.24) M) > triallate (IC50 = 10(-3.12) M) > simazine (IC50 = 10(-1.78) M). The comparison of average IC50 values of cell cultures revealed that the most sensitive cell lines were PK15 (IC50 = 10(-3.27) M) and RK13 (IC50 = 10(-3.21) M), whereas MDBK (IC50 = 10(-2.55) M) and BEPC (IC50 = 10(-2.52) M) were less sensitive to pesticide exposure.
PMID: 17385544
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