|
|
char = p;code = 112
char = 5;code = 53
char = 3;code = 51
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
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char = s;code = 115
char = t;code = 116
char = i;code = 105
char = t;code = 116
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = r;code = 114
char = ;code = 32
char = (;code = 40
char = A;code = 65
char = P;code = 80
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char = g;code = 103
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char = t;code = 116
char = i;code = 105
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char = o;code = 111
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char = ;code = 32
char = h;code = 104
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char = m;code = 109
char = a;code = 97
char = n;code = 110
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char = u;code = 117
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char = o;code = 111
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char = e;code = 101
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char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells.
p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells.char = A;code = 65
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char = t;code = 116
char = i;code = 105
char = p;code = 112
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char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = A;code = 65
char = P;code = 80
char = F;code = 70
char = );code = 41
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = s;code = 115
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char = l;code = 108
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char = p;code = 112
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char = d;code = 100
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char = e;code = 101
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char = t;code = 116
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char = t;code = 116
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char = d;code = 100
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char = e;code = 101
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char = o;code = 111
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char = n;code = 110
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char = p;code = 112
char = e;code = 101
char = l;code = 108
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char = p;code = 112
char = a;code = 97
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char = T;code = 84
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char = s;code = 115
char = t;code = 116
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char = ;code = 32
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char = i;code = 105
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char = c;code = 99
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = a;code = 97
char = r;code = 114
char = d;code = 100
char = ;code = 32
char = u;code = 117
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char = o;code = 111
char = v;code = 118
char = e;code = 101
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
char = a;code = 97
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char = h;code = 104
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char = a;code = 97
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char = w;code = 119
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char = A;code = 65
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char = F;code = 70
char = ;code = 32
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char = a;code = 97
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char = m;code = 109
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char = n;code = 110
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char = o;code = 111
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char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = ;code = 32
char = w;code = 119
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char = A;code = 65
char = P;code = 80
char = F;code = 70
char = ;code = 32
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char = g;code = 103
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = b;code = 98
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char = a;code = 97
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = i;code = 105
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char = R;code = 82
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char = u;code = 117
char = c;code = 99
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char = x;code = 120
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char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = p;code = 112
char = 5;code = 53
char = 3;code = 51
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char = b;code = 98
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char = R;code = 82
char = N;code = 78
char = A;code = 65
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char = i;code = 105
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char = d;code = 100
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char = m;code = 109
char = i;code = 105
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char = ,;code = 44
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char = i;code = 105
char = l;code = 108
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char = e;code = 101
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char = c;code = 99
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char = m;code = 109
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char = i;code = 105
char = n;code = 110
char = t;code = 116
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char = t;code = 116
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char = t;code = 116
char = i;code = 105
char = a;code = 97
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char = c;code = 99
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char = t;code = 116
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result sql = Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis, a urinary bladder disorder of unknown etiology that is characterized by chronic pelvic pain. The present study was directed toward uncovering a pathway through which APF signals. Treatment of human urothelial cells with native APF resulted in growth inhibition accompanied by blockade of cell cycle transit and increased p53. Reduced expression of p53 by RNA interference diminished, while ectopic expression of p53 mimicked, the effects of APF. These are the first findings implicating the network of p53 target genes in urothelial defects associated with interstitial cystitis.
char = 5;code = 53
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char = e;code = 101
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = s;code = 115
char = t;code = 116
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char = t;code = 116
char = i;code = 105
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char = t;code = 116
char = i;code = 105
char = p;code = 112
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char = l;code = 108
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char = f;code = 102
char = e;code = 101
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char = v;code = 118
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result sql = p53 mediates interstitial cystitis antiproliferative factor (APF)-induced growth inhibition of human urothelial cells.
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char = t;code = 116
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char = ;code = 32
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char = w;code = 119
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char = ;code = 32
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char = m;code = 109
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char = i;code = 105
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char = l;code = 108
char = ;code = 32
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char = l;code = 108
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char = ;code = 32
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = n;code = 110
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char = i;code = 105
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char = s;code = 115
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char = n;code = 110
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char = p;code = 112
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result sql = Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis, a urinary bladder disorder of unknown etiology that is characterized by chronic pelvic pain. The present study was directed toward uncovering a pathway through which APF signals. Treatment of human urothelial cells with native APF resulted in growth inhibition accompanied by blockade of cell cycle transit and increased p53. Reduced expression of p53 by RNA interference diminished, while ectopic expression of p53 mimicked, the effects of APF. These are the first findings implicating the network of p53 target genes in urothelial defects associated with interstitial cystitis.
Publication: FEBS Lett. 2007 Aug 7 ;581(20)::3795-9.
Publication Date: 2007 Aug 7
Study Author(s): Kim, Jayoung;Keay, Susan K;Dimitrakov, Jordan D;Freeman, Michael R;
Institution: The Urological Diseases Research Center, Children's Hospital Boston, Boston, MA 02115, USA.
Shortcut link to this study:
Publication Date: 2007 Aug 7
Study Author(s): Kim, Jayoung;Keay, Susan K;Dimitrakov, Jordan D;Freeman, Michael R;
Institution: The Urological Diseases Research Center, Children's Hospital Boston, Boston, MA 02115, USA.
Shortcut link to this study:
Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis, a urinary bladder disorder of unknown etiology that is characterized by chronic pelvic pain. The present study was directed toward uncovering a pathway through which APF signals. Treatment of human urothelial cells with native APF resulted in growth inhibition accompanied by blockade of cell cycle transit and increased p53. Reduced expression of p53 by RNA interference diminished, while ectopic expression of p53 mimicked, the effects of APF. These are the first findings implicating the network of p53 target genes in urothelial defects associated with interstitial cystitis.
PMID: 17628545
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