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char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = u;code = 117
char = l;code = 108
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char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = r;code = 114
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char = n;code = 110
char = i;code = 105
char = d;code = 100
char = a;code = 97
char = z;code = 122
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = a;code = 97
char = c;code = 99
char = r;code = 114
char = y;code = 121
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = The effect of methylcellulose on metronidazole release from polyacrylic acid hydrogels.
The effect of methylcellulose on metronidazole release from polyacrylic acid hydrogels.
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char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = n;code = 110
char = e;code = 101
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char = r;code = 114
char = o;code = 111
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char = a;code = 97
char = c;code = 99
char = e;code = 101
char = a;code = 97
char = ,;code = 44
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char = a;code = 97
char = ;code = 32
char = c;code = 99
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char = ;code = 32
char = c;code = 99
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char = d;code = 100
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char = i;code = 105
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char = a;code = 97
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char = a;code = 97
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char = z;code = 122
char = e;code = 101
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char = r;code = 114
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char = y;code = 121
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char = ,;code = 44
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char = s;code = 115
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char = i;code = 105
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char = d;code = 100
char = a;code = 97
char = z;code = 122
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = i;code = 105
char = m;code = 109
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = t;code = 116
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char = o;code = 111
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char = ;code = 32
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char = a;code = 97
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char = i;code = 105
char = o;code = 111
char = u;code = 117
char = s;code = 115
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char = r;code = 114
char = y;code = 121
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char = c;code = 99
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char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
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char = l;code = 108
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char = m;code = 109
char = e;code = 101
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char = ,;code = 44
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char = ;code = 32
char = m;code = 109
char = e;code = 101
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char = r;code = 114
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char = l;code = 108
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char = s;code = 115
char = ;code = 32
char = p;code = 112
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char = ;code = 32
char = t;code = 116
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char = ;code = 32
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char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = m;code = 109
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char = t;code = 116
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char = f;code = 102
char = ;code = 32
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
char = a;code = 97
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char = V;code = 86
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char = ;code = 32
char = ";code = 34
char = P;code = 80
char = a;code = 97
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char = d;code = 100
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = D;code = 68
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = ";code = 34
char = ;code = 32
char = s;code = 115
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char = s;code = 115
char = t;code = 116
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char = p;code = 112
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char = m;code = 109
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char = C;code = 67
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char = 3;code = 51
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char = 0;code = 48
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char = t;code = 116
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char = e;code = 101
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char = i;code = 105
char = s;code = 115
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char = r;code = 114
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char = b;code = 98
char = u;code = 117
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char = n;code = 110
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char = n;code = 110
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char = o;code = 111
char = ;code = 32
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char = o;code = 111
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char = m;code = 109
char = e;code = 101
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char = s;code = 115
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char = p;code = 112
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char = i;code = 105
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result sql = Topical treatment of acne rosacea, a chronic condition characterized by recurrent course for many years, is primarily based on metronidazole preparations. The aim of this study was to evaluate the effect of various acrylic acid polymers, in composition with methylcellulose on metronidazole release rate from hydrogels proposed for the treatment of acne rosacea. Viscosity and release studies using "Paddle over Disk" system with semipermeable membrane of MWCO 3500 were performed. Compositions of Carbopol 971P and methylcellulose revealed an increase in viscosity with increasing concentration of methylcellulose in the range of 17200-26166 mPa.s. In all the examined formulations, the release process was characterized by a two-stage course. Among bipolymeric formulations, the highest first-stage release rate of 9.18 x 10(-3) min(-1) was determined for the gel consisting of 2.00% Carbopol 980NF with 1.00% methylcellulose. The second-stage release rates ranged between 2.88 x 10(-3) and 8.00 x 10(-3) min(-1). Two-stage release course can thus be attributed to metronidazole distribution into two compartments of hydrogel matrix. Proposed gels, with similar rheological properties, may be used for ex vivo and in vivo studies to obtain a suitable drug activity of metronidazole in the treatment of acne rosacea.

Publication: Chem. Pharm. Bull. 2007 Aug ;55(8)::1141-7.
Publication Date: 2007 Aug
Study Author(s): Musial, Witold;
Institution: Drug Form Technology Unit, Wroclaw Medical University, Wroclaw, Poland. [email protected]
Shortcut link to this study:
Topical treatment of acne rosacea, a chronic condition characterized by recurrent course for many years, is primarily based on metronidazole preparations. The aim of this study was to evaluate the effect of various acrylic acid polymers, in composition with methylcellulose on metronidazole release rate from hydrogels proposed for the treatment of acne rosacea. Viscosity and release studies using "Paddle over Disk" system with semipermeable membrane of MWCO 3500 were performed. Compositions of Carbopol 971P and methylcellulose revealed an increase in viscosity with increasing concentration of methylcellulose in the range of 17200-26166 mPa.s. In all the examined formulations, the release process was characterized by a two-stage course. Among bipolymeric formulations, the highest first-stage release rate of 9.18 x 10(-3) min(-1) was determined for the gel consisting of 2.00% Carbopol 980NF with 1.00% methylcellulose. The second-stage release rates ranged between 2.88 x 10(-3) and 8.00 x 10(-3) min(-1). Two-stage release course can thus be attributed to metronidazole distribution into two compartments of hydrogel matrix. Proposed gels, with similar rheological properties, may be used for ex vivo and in vivo studies to obtain a suitable drug activity of metronidazole in the treatment of acne rosacea.
PMID: 17666834

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