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result sql = BACKGROUND : Dermatologists may be called to assist in the diagnosis and management of purpura fulminans.
METHODS : This retrospective case series details the clinical presentation and outcomes of patients presenting with purpura fulminans associated with peripheral gangrene between 1989 and 2004.
RESULTS : All 12 patients presented with sudden onset of purpuric patches and evolving gangrene of the extremities in association with a shock syndrome (hypotension, oliguria). Eleven patients had disseminated intravascular coagulation. The cause of purpura fulminans was infectious in 9 patients, surgical in two, and cancer in one. Three patients died (25%) within a week of onset of purpura fulminans. Of the 9 surviving patients, 8 required amputation of at least one limb. Four patients required amputation of all 4 limbs.
LIMITATIONS : Retrospective study design, varying clinical descriptions, and potential referral bias are limitations.
CONCLUSION : Purpura fulminans in association with symmetric peripheral gangrene is an ominous clinical presentation.
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result sql = Presentation and outcome of purpura fulminans associated with peripheral gangrene in 12 patients at Mayo Clinic.
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char = o;code = 111
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char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = p;code = 112
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char = r;code = 114
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char = n;code = 110
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char = .;code = 46
char = ;code = 32
char = O;code = 79
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = 9;code = 57
char = ;code = 32
char = s;code = 115
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char = e;code = 101
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char = s;code = 115
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char = ;code = 32
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char = q;code = 113
char = u;code = 117
char = i;code = 105
char = r;code = 114
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char = m;code = 109
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char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = ;code = 32
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char = e;code = 101
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = m;code = 109
char = b;code = 98
char = .;code = 46
char = ;code = 32
char = F;code = 70
char = o;code = 111
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char = ;code = 32
char = p;code = 112
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char = t;code = 116
char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = i;code = 105
char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = o;code = 111
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char = l;code = 108
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char = ;code = 32
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char = i;code = 105
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char = b;code = 98
char = s;code = 115
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char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
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char = L;code = 76
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char = M;code = 77
char = I;code = 73
char = T;code = 84
char = A;code = 65
char = T;code = 84
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = e;code = 101
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = c;code = 99
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char = i;code = 105
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char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ,;code = 44
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char = ;code = 32
char = a;code = 97
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char = e;code = 101
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
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char = C;code = 67
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char = I;code = 73
char = O;code = 79
char = N;code = 78
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char = l;code = 108
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char = n;code = 110
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = m;code = 109
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = g;code = 103
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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result sql = BACKGROUND : Dermatologists may be called to assist in the diagnosis and management of purpura fulminans.
METHODS : This retrospective case series details the clinical presentation and outcomes of patients presenting with purpura fulminans associated with peripheral gangrene between 1989 and 2004.
RESULTS : All 12 patients presented with sudden onset of purpuric patches and evolving gangrene of the extremities in association with a shock syndrome (hypotension, oliguria). Eleven patients had disseminated intravascular coagulation. The cause of purpura fulminans was infectious in 9 patients, surgical in two, and cancer in one. Three patients died (25%) within a week of onset of purpura fulminans. Of the 9 surviving patients, 8 required amputation of at least one limb. Four patients required amputation of all 4 limbs.
LIMITATIONS : Retrospective study design, varying clinical descriptions, and potential referral bias are limitations.
CONCLUSION : Purpura fulminans in association with symmetric peripheral gangrene is an ominous clinical presentation.
Publication: J. Am. Acad. Dermatol. 2007 Dec ;57(6)::944-56.
Publication Date: 2007 Dec
Study Author(s): Davis, Mark D P;Dy, Katrina M;Nelson, Steven;
Institution: Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA. [email protected]
Shortcut link to this study:
Publication Date: 2007 Dec
Study Author(s): Davis, Mark D P;Dy, Katrina M;Nelson, Steven;
Institution: Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA. [email protected]
Shortcut link to this study:
BACKGROUND : Dermatologists may be called to assist in the diagnosis and management of purpura fulminans.
METHODS : This retrospective case series details the clinical presentation and outcomes of patients presenting with purpura fulminans associated with peripheral gangrene between 1989 and 2004.
RESULTS : All 12 patients presented with sudden onset of purpuric patches and evolving gangrene of the extremities in association with a shock syndrome (hypotension, oliguria). Eleven patients had disseminated intravascular coagulation. The cause of purpura fulminans was infectious in 9 patients, surgical in two, and cancer in one. Three patients died (25%) within a week of onset of purpura fulminans. Of the 9 surviving patients, 8 required amputation of at least one limb. Four patients required amputation of all 4 limbs.
LIMITATIONS : Retrospective study design, varying clinical descriptions, and potential referral bias are limitations.
CONCLUSION : Purpura fulminans in association with symmetric peripheral gangrene is an ominous clinical presentation.
METHODS : This retrospective case series details the clinical presentation and outcomes of patients presenting with purpura fulminans associated with peripheral gangrene between 1989 and 2004.
RESULTS : All 12 patients presented with sudden onset of purpuric patches and evolving gangrene of the extremities in association with a shock syndrome (hypotension, oliguria). Eleven patients had disseminated intravascular coagulation. The cause of purpura fulminans was infectious in 9 patients, surgical in two, and cancer in one. Three patients died (25%) within a week of onset of purpura fulminans. Of the 9 surviving patients, 8 required amputation of at least one limb. Four patients required amputation of all 4 limbs.
LIMITATIONS : Retrospective study design, varying clinical descriptions, and potential referral bias are limitations.
CONCLUSION : Purpura fulminans in association with symmetric peripheral gangrene is an ominous clinical presentation.
PMID: 17719676
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