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result sql = Naringenin (Nar) is a component of fruits and vegetables associated with healthful benefits, such as in osteoporosis, cancer, and cardiovascular diseases. These protective effects have been linked with Nar antiestrogenic as well as estrogenic activities. Previous studies indicate that Nar impaired estrogen receptor (ER) alpha signaling by interfering with ERalpha-mediated activation of ERK and phosphoinositide 3-kinase signaling pathways in the absence of effects at the transcriptional level. The present studies evaluated the hypothesis that these Nar antagonistic effects occur at the level of the plasma membrane. Our results indicate that Nar induces ERalpha depalmitoylation faster than 17beta-estradiol, which results in receptor rapid dissociation from caveolin-1. Furthermore, Nar impedes ERalpha to bind adaptor (modulator of nongenomic actions of the ER) and signaling (c-Src) proteins involved in the activation of the mitogenic signaling cascades (i.e. ERK and phosphoinositide 3-kinase). On the other hand, Nar induces the ER-dependent, but palmitoylation-independent, activation of p38 kinase, which in turn is responsible for Nar-mediated antiproliferative effects in cancer cells. Altogether, these data highlight new ER-dependent mechanisms on the root of antiproliferative and antiestrogenic effects of Nar. Moreover, the different modulation of ERalpha palmitoylation exerted by different ligands represents a pivotal mechanism that drives cancer cell to proliferation or apoptosis.
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result sql = The nutritional flavanone naringenin triggers antiestrogenic effects by regulating estrogen receptor alpha-palmitoylation.
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char = g;code = 103
char = e;code = 101
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char = a;code = 97
char = s;code = 115
char = s;code = 115
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char = a;code = 97
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char = t;code = 116
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char = h;code = 104
char = e;code = 101
char = a;code = 97
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char = t;code = 116
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char = f;code = 102
char = u;code = 117
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char = b;code = 98
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char = e;code = 101
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char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = s;code = 115
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char = c;code = 99
char = h;code = 104
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char = a;code = 97
char = s;code = 115
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char = i;code = 105
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char = o;code = 111
char = s;code = 115
char = t;code = 116
char = e;code = 101
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char = p;code = 112
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char = s;code = 115
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char = s;code = 115
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char = ;code = 32
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char = a;code = 97
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char = c;code = 99
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char = r;code = 114
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char = a;code = 97
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char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = a;code = 97
char = s;code = 115
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = d;code = 100
char = i;code = 105
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = p;code = 112
char = r;code = 114
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char = c;code = 99
char = t;code = 116
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = h;code = 104
char = a;code = 97
char = v;code = 118
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char = b;code = 98
char = e;code = 101
char = e;code = 101
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char = l;code = 108
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char = n;code = 110
char = k;code = 107
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = N;code = 78
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = s;code = 115
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = P;code = 80
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = i;code = 105
char = o;code = 111
char = u;code = 117
char = s;code = 115
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char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = N;code = 78
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = i;code = 105
char = r;code = 114
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char = d;code = 100
char = ;code = 32
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = o;code = 111
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char = e;code = 101
char = n;code = 110
char = ;code = 32
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
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char = r;code = 114
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char = (;code = 40
char = E;code = 69
char = R;code = 82
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char = ;code = 32
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = s;code = 115
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char = g;code = 103
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = b;code = 98
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char = t;code = 116
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char = f;code = 102
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
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char = E;code = 69
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char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = a;code = 97
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char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
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char = ;code = 32
char = E;code = 69
char = R;code = 82
char = K;code = 75
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = p;code = 112
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char = o;code = 111
char = s;code = 115
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char = h;code = 104
char = o;code = 111
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char = n;code = 110
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
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char = d;code = 100
char = e;code = 101
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char = n;code = 110
char = a;code = 97
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char = s;code = 115
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char = g;code = 103
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char = a;code = 97
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = w;code = 119
char = a;code = 97
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char = t;code = 116
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char = f;code = 102
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char = e;code = 101
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char = t;code = 116
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char = e;code = 101
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char = N;code = 78
char = a;code = 97
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char = a;code = 97
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char = f;code = 102
char = e;code = 101
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char = .;code = 46
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char = O;code = 79
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char = r;code = 114
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char = s;code = 115
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char = t;code = 116
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char = t;code = 116
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char = a;code = 97
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char = i;code = 105
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char = u;code = 117
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char = N;code = 78
char = a;code = 97
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char = i;code = 105
char = m;code = 109
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char = e;code = 101
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char = E;code = 69
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char = a;code = 97
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char = a;code = 97
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char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
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char = E;code = 69
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char = s;code = 115
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char = e;code = 101
char = s;code = 115
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char = (;code = 40
char = i;code = 105
char = .;code = 46
char = e;code = 101
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result sql = Naringenin (Nar) is a component of fruits and vegetables associated with healthful benefits, such as in osteoporosis, cancer, and cardiovascular diseases. These protective effects have been linked with Nar antiestrogenic as well as estrogenic activities. Previous studies indicate that Nar impaired estrogen receptor (ER) alpha signaling by interfering with ERalpha-mediated activation of ERK and phosphoinositide 3-kinase signaling pathways in the absence of effects at the transcriptional level. The present studies evaluated the hypothesis that these Nar antagonistic effects occur at the level of the plasma membrane. Our results indicate that Nar induces ERalpha depalmitoylation faster than 17beta-estradiol, which results in receptor rapid dissociation from caveolin-1. Furthermore, Nar impedes ERalpha to bind adaptor (modulator of nongenomic actions of the ER) and signaling (c-Src) proteins involved in the activation of the mitogenic signaling cascades (i.e. ERK and phosphoinositide 3-kinase). On the other hand, Nar induces the ER-dependent, but palmitoylation-independent, activation of p38 kinase, which in turn is responsible for Nar-mediated antiproliferative effects in cancer cells. Altogether, these data highlight new ER-dependent mechanisms on the root of antiproliferative and antiestrogenic effects of Nar. Moreover, the different modulation of ERalpha palmitoylation exerted by different ligands represents a pivotal mechanism that drives cancer cell to proliferation or apoptosis.
Publication: Endocrinology 2008 May ;149(5)::2567-75. :doi: 10.1210/en.2007-1173.
Publication Date: 2008 May
Study Author(s): Galluzzo, Paola;Ascenzi, Paolo;Bulzomi, Pamela;Marino, Maria;
Institution: Department of Biology, University Roma Tre, Viale G. Marconi, 446, I-00146 Roma, Italy.
Shortcut link to this study:
Publication Date: 2008 May
Study Author(s): Galluzzo, Paola;Ascenzi, Paolo;Bulzomi, Pamela;Marino, Maria;
Institution: Department of Biology, University Roma Tre, Viale G. Marconi, 446, I-00146 Roma, Italy.
Shortcut link to this study:
Naringenin (Nar) is a component of fruits and vegetables associated with healthful benefits, such as in osteoporosis, cancer, and cardiovascular diseases. These protective effects have been linked with Nar antiestrogenic as well as estrogenic activities. Previous studies indicate that Nar impaired estrogen receptor (ER) alpha signaling by interfering with ERalpha-mediated activation of ERK and phosphoinositide 3-kinase signaling pathways in the absence of effects at the transcriptional level. The present studies evaluated the hypothesis that these Nar antagonistic effects occur at the level of the plasma membrane. Our results indicate that Nar induces ERalpha depalmitoylation faster than 17beta-estradiol, which results in receptor rapid dissociation from caveolin-1. Furthermore, Nar impedes ERalpha to bind adaptor (modulator of nongenomic actions of the ER) and signaling (c-Src) proteins involved in the activation of the mitogenic signaling cascades (i.e. ERK and phosphoinositide 3-kinase). On the other hand, Nar induces the ER-dependent, but palmitoylation-independent, activation of p38 kinase, which in turn is responsible for Nar-mediated antiproliferative effects in cancer cells. Altogether, these data highlight new ER-dependent mechanisms on the root of antiproliferative and antiestrogenic effects of Nar. Moreover, the different modulation of ERalpha palmitoylation exerted by different ligands represents a pivotal mechanism that drives cancer cell to proliferation or apoptosis.
PMID: 18239068
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