|
|
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result sql = Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration.
Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration.char = A;code = 65
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char = r;code = 114
char = e;code = 101
char = g;code = 103
char = e;code = 101
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char = r;code = 114
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char = a;code = 97
char = s;code = 115
char = s;code = 115
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char = a;code = 97
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char = t;code = 116
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char = a;code = 97
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = e;code = 101
char = a;code = 97
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char = i;code = 105
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char = h;code = 104
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char = p;code = 112
char = a;code = 97
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char = o;code = 111
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char = t;code = 116
char = e;code = 101
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char = n;code = 110
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = r;code = 114
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char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = (;code = 40
char = H;code = 72
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = 4;code = 52
char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = ,;code = 44
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char = a;code = 97
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = -;code = 45
char = e;code = 101
char = n;code = 110
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = d;code = 100
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char = ;code = 32
char = z;code = 122
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char = n;code = 110
char = c;code = 99
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char = f;code = 102
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = c;code = 99
char = r;code = 114
char = i;code = 105
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = .;code = 46
char = ;code = 32
char = S;code = 83
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = H;code = 72
char = e;code = 101
char = p;code = 112
char = G;code = 71
char = 2;code = 50
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = z;code = 122
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = y;code = 121
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char = s;code = 115
char = u;code = 117
char = p;code = 112
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = -;code = 45
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = H;code = 72
char = G;code = 71
char = F;code = 70
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = -;code = 45
char = l;code = 108
char = i;code = 105
char = k;code = 107
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = I;code = 73
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = -;code = 45
char = I;code = 73
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = -;code = 45
char = l;code = 108
char = i;code = 105
char = k;code = 107
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = f;code = 102
char = a;code = 97
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char = t;code = 116
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char = r;code = 114
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char = t;code = 116
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char = i;code = 105
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char = 1;code = 49
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = B;code = 66
char = P;code = 80
char = 1;code = 49
char = );code = 41
char = ,;code = 44
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char = m;code = 109
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char = t;code = 116
char = a;code = 97
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char = l;code = 108
char = o;code = 111
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char = h;code = 104
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = i;code = 105
char = n;code = 110
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char = M;code = 77
char = T;code = 84
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = c;code = 99
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = D;code = 68
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = H;code = 72
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = 4;code = 52
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = 4;code = 52
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = l;code = 108
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = -;code = 45
char = I;code = 73
char = ,;code = 44
char = ;code = 32
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = B;code = 66
char = P;code = 80
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = M;code = 77
char = T;code = 84
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = c;code = 99
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = D;code = 68
char = 1;code = 49
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
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char = n;code = 110
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char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = v;code = 118
char = i;code = 105
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char = e;code = 101
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char = e;code = 101
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char = z;code = 122
char = i;code = 105
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char = c;code = 99
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char = e;code = 101
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char = i;code = 105
char = o;code = 111
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char = e;code = 101
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char = i;code = 105
char = v;code = 118
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char = r;code = 114
char = e;code = 101
char = g;code = 103
char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = o;code = 111
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char = a;code = 97
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char = ;code = 32
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
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char = p;code = 112
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = H;code = 72
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = 4;code = 52
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = u;code = 117
char = p;code = 112
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char = r;code = 114
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char = g;code = 103
char = u;code = 117
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = o;code = 111
char = f;code = 102
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char = c;code = 99
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char = l;code = 108
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char = i;code = 105
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char = e;code = 101
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = p;code = 112
char = r;code = 114
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char = e;code = 101
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char = n;code = 110
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = s;code = 115
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char = g;code = 103
char = g;code = 103
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char = s;code = 115
char = t;code = 116
char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = t;code = 116
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char = a;code = 97
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char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = y;code = 121
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char = z;code = 122
char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = s;code = 115
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char = p;code = 112
char = p;code = 112
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char = e;code = 101
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char = t;code = 116
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
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char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = b;code = 98
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = l;code = 108
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = l;code = 108
char = c;code = 99
char = o;code = 111
char = h;code = 104
char = o;code = 111
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = d;code = 100
char = i;code = 105
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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result sql = Alcoholic liver disease is associated with sustained liver damage and impaired regeneration, as well as significant zinc deficiency. This study was undertaken to examine whether dietary zinc supplementation could improve liver regeneration by increasing the expression of genes involved in hepatic cellular proliferation in a mouse model of alcoholic liver disease. Adult 129S6 mice fed an ethanol-containing liquid diet for 6 months developed alcoholic liver disease as measured by serum alanine transferase activity and histopathological changes. Zinc supplementation to ethanol-exposed mice enhanced liver regeneration as indicated by increased numbers of proliferation cell nuclear antigen (PCNA)-positive and bromodeoxyuridine (BrdU)-labeled hepatocytes. Zinc-enhanced liver regeneration was associated with an increase in hepatocyte nuclear factor-4alpha (HNF-4alpha), a liver-enriched, zinc-finger transcription factor. Studies using cultured HepG2 cells showed that zinc deficiency suppressed cell proliferation and cell proliferation-related proteins, including hepatocyte growth factor (HGF), insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 1 (IGFBP1), metallothionein (MT), and cyclin D1, as well as HNF-4alpha. HNF-4alpha gene silencing inhibited cell proliferation in association with decreased protein levels of IGF-I, IGFBP1, MT, and cyclin D1. The present study provides evidence that zinc supplementation enhances liver regeneration at least in part by HNF-4alpha through the up-regulation of cell proliferation-related proteins, suggesting that dietary zinc supplementation may have beneficial effects in alcoholic liver disease.
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result sql = Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration.
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char = ;code = 32
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char = U;code = 85
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char = a;code = 97
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char = l;code = 108
char = e;code = 101
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char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
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char = o;code = 111
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char = y;code = 121
char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = ;code = 32
char = Z;code = 90
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = -;code = 45
char = e;code = 101
char = n;code = 110
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = d;code = 100
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char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = r;code = 114
char = e;code = 101
char = g;code = 103
char = e;code = 101
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char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = c;code = 99
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char = t;code = 116
char = e;code = 101
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char = n;code = 110
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
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char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = H;code = 72
char = N;code = 78
char = F;code = 70
char = -;code = 45
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char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = ,;code = 44
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char = a;code = 97
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char = l;code = 108
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = -;code = 45
char = e;code = 101
char = n;code = 110
char = r;code = 114
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = d;code = 100
char = ,;code = 44
char = ;code = 32
char = z;code = 122
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = -;code = 45
char = f;code = 102
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = c;code = 99
char = r;code = 114
char = i;code = 105
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = .;code = 46
char = ;code = 32
char = S;code = 83
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char = u;code = 117
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = s;code = 115
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char = u;code = 117
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = H;code = 72
char = e;code = 101
char = p;code = 112
char = G;code = 71
char = 2;code = 50
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
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char = a;code = 97
char = t;code = 116
char = ;code = 32
char = z;code = 122
char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = d;code = 100
char = e;code = 101
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = e;code = 101
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char = c;code = 99
char = y;code = 121
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char = s;code = 115
char = u;code = 117
char = p;code = 112
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = e;code = 101
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char = n;code = 110
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char = ,;code = 44
char = ;code = 32
char = i;code = 105
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char = c;code = 99
char = l;code = 108
char = u;code = 117
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = H;code = 72
char = G;code = 71
char = F;code = 70
char = );code = 41
char = ,;code = 44
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char = i;code = 105
char = n;code = 110
char = s;code = 115
char = u;code = 117
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char = i;code = 105
char = n;code = 110
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char = l;code = 108
char = i;code = 105
char = k;code = 107
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char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = I;code = 73
char = ;code = 32
char = (;code = 40
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = -;code = 45
char = I;code = 73
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char = ,;code = 44
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char = s;code = 115
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char = l;code = 108
char = i;code = 105
char = k;code = 107
char = e;code = 101
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char = r;code = 114
char = o;code = 111
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char = h;code = 104
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char = f;code = 102
char = a;code = 97
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char = o;code = 111
char = r;code = 114
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char = b;code = 98
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char = p;code = 112
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char = o;code = 111
char = t;code = 116
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char = i;code = 105
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char = 1;code = 49
char = ;code = 32
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char = I;code = 73
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char = F;code = 70
char = B;code = 66
char = P;code = 80
char = 1;code = 49
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char = ,;code = 44
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char = m;code = 109
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char = t;code = 116
char = a;code = 97
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char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = n;code = 110
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char = M;code = 77
char = T;code = 84
char = );code = 41
char = ,;code = 44
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = c;code = 99
char = l;code = 108
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char = D;code = 68
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = H;code = 72
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = 4;code = 52
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = 4;code = 52
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = g;code = 103
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char = e;code = 101
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char = s;code = 115
char = i;code = 105
char = l;code = 108
char = e;code = 101
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char = c;code = 99
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char = n;code = 110
char = g;code = 103
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char = i;code = 105
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char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = l;code = 108
char = l;code = 108
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char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = f;code = 102
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char = r;code = 114
char = a;code = 97
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char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
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char = d;code = 100
char = e;code = 101
char = c;code = 99
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char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
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char = n;code = 110
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char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = I;code = 73
char = G;code = 71
char = F;code = 70
char = -;code = 45
char = I;code = 73
char = ,;code = 44
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char = I;code = 73
char = G;code = 71
char = F;code = 70
char = B;code = 66
char = P;code = 80
char = 1;code = 49
char = ,;code = 44
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char = M;code = 77
char = T;code = 84
char = ,;code = 44
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = c;code = 99
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char = i;code = 105
char = n;code = 110
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char = D;code = 68
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = p;code = 112
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char = e;code = 101
char = s;code = 115
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char = a;code = 97
char = r;code = 114
char = t;code = 116
char = ;code = 32
char = b;code = 98
char = y;code = 121
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char = H;code = 72
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = 4;code = 52
char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = o;code = 111
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char = g;code = 103
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char = e;code = 101
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char = u;code = 117
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char = c;code = 99
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char = t;code = 116
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char = y;code = 121
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char = z;code = 122
char = i;code = 105
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char = a;code = 97
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char = b;code = 98
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char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
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result sql = Alcoholic liver disease is associated with sustained liver damage and impaired regeneration, as well as significant zinc deficiency. This study was undertaken to examine whether dietary zinc supplementation could improve liver regeneration by increasing the expression of genes involved in hepatic cellular proliferation in a mouse model of alcoholic liver disease. Adult 129S6 mice fed an ethanol-containing liquid diet for 6 months developed alcoholic liver disease as measured by serum alanine transferase activity and histopathological changes. Zinc supplementation to ethanol-exposed mice enhanced liver regeneration as indicated by increased numbers of proliferation cell nuclear antigen (PCNA)-positive and bromodeoxyuridine (BrdU)-labeled hepatocytes. Zinc-enhanced liver regeneration was associated with an increase in hepatocyte nuclear factor-4alpha (HNF-4alpha), a liver-enriched, zinc-finger transcription factor. Studies using cultured HepG2 cells showed that zinc deficiency suppressed cell proliferation and cell proliferation-related proteins, including hepatocyte growth factor (HGF), insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 1 (IGFBP1), metallothionein (MT), and cyclin D1, as well as HNF-4alpha. HNF-4alpha gene silencing inhibited cell proliferation in association with decreased protein levels of IGF-I, IGFBP1, MT, and cyclin D1. The present study provides evidence that zinc supplementation enhances liver regeneration at least in part by HNF-4alpha through the up-regulation of cell proliferation-related proteins, suggesting that dietary zinc supplementation may have beneficial effects in alcoholic liver disease.
Publication: Am. J. Pathol. 2008 Apr ;172(4)::916-25. :doi: 10.2353/ajpath.2008.070631.
Publication Date: 2008 Apr
Study Author(s): Kang, Xinqin;Song, Zhenyuan;McClain, Craig J;Kang, Y James;Zhou, Zhanxiang;
Institution: Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, Louisville, KY 40292, USA.
Shortcut link to this study:
Publication Date: 2008 Apr
Study Author(s): Kang, Xinqin;Song, Zhenyuan;McClain, Craig J;Kang, Y James;Zhou, Zhanxiang;
Institution: Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, Louisville, KY 40292, USA.
Shortcut link to this study:
Alcoholic liver disease is associated with sustained liver damage and impaired regeneration, as well as significant zinc deficiency. This study was undertaken to examine whether dietary zinc supplementation could improve liver regeneration by increasing the expression of genes involved in hepatic cellular proliferation in a mouse model of alcoholic liver disease. Adult 129S6 mice fed an ethanol-containing liquid diet for 6 months developed alcoholic liver disease as measured by serum alanine transferase activity and histopathological changes. Zinc supplementation to ethanol-exposed mice enhanced liver regeneration as indicated by increased numbers of proliferation cell nuclear antigen (PCNA)-positive and bromodeoxyuridine (BrdU)-labeled hepatocytes. Zinc-enhanced liver regeneration was associated with an increase in hepatocyte nuclear factor-4alpha (HNF-4alpha), a liver-enriched, zinc-finger transcription factor. Studies using cultured HepG2 cells showed that zinc deficiency suppressed cell proliferation and cell proliferation-related proteins, including hepatocyte growth factor (HGF), insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 1 (IGFBP1), metallothionein (MT), and cyclin D1, as well as HNF-4alpha. HNF-4alpha gene silencing inhibited cell proliferation in association with decreased protein levels of IGF-I, IGFBP1, MT, and cyclin D1. The present study provides evidence that zinc supplementation enhances liver regeneration at least in part by HNF-4alpha through the up-regulation of cell proliferation-related proteins, suggesting that dietary zinc supplementation may have beneficial effects in alcoholic liver disease.
PMID: 18349129
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