|
|
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result sql = Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker.
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result sql = A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA+DHA levels (the omega-3 index). Overweight healthy volunteers (n=45) were randomized to SDA-SBO (24 ml/day providing approximately 3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (approximately 1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p<0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs.
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result sql = Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker.
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char = i;code = 105
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char = H;code = 72
char = A;code = 65
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char = ;code = 32
char = i;code = 105
char = s;code = 115
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char = n;code = 110
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char = e;code = 101
char = d;code = 100
char = e;code = 101
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = ;code = 32
char = s;code = 115
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char = y;code = 121
char = b;code = 98
char = e;code = 101
char = a;code = 97
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char = ;code = 32
char = o;code = 111
char = i;code = 105
char = l;code = 108
char = ;code = 32
char = (;code = 40
char = S;code = 83
char = B;code = 66
char = O;code = 79
char = );code = 41
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = l;code = 108
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char = 2;code = 50
char = 0;code = 48
char = %;code = 37
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = d;code = 100
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
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char = [;code = 91
char = S;code = 83
char = D;code = 68
char = A;code = 65
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = l;code = 108
char = t;code = 116
char = a;code = 97
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char = 6;code = 54
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char = d;code = 100
char = e;code = 101
char = s;code = 115
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
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char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = l;code = 108
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
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char = A;code = 65
char = L;code = 76
char = A;code = 65
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char = ];code = 93
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
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char = m;code = 109
char = o;code = 111
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = s;code = 115
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char = y;code = 121
char = b;code = 98
char = e;code = 101
char = a;code = 97
char = n;code = 110
char = s;code = 115
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
char = c;code = 99
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char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = E;code = 69
char = P;code = 80
char = A;code = 65
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = S;code = 83
char = D;code = 68
char = A;code = 65
char = -;code = 45
char = S;code = 83
char = B;code = 66
char = O;code = 79
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = r;code = 114
char = y;code = 121
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = E;code = 69
char = P;code = 80
char = A;code = 65
char = +;code = 43
char = D;code = 68
char = H;code = 72
char = A;code = 65
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = o;code = 111
char = m;code = 109
char = e;code = 101
char = g;code = 103
char = a;code = 97
char = -;code = 45
char = 3;code = 51
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = x;code = 120
char = );code = 41
char = .;code = 46
char = ;code = 32
char = O;code = 79
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = w;code = 119
char = e;code = 101
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
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char = h;code = 104
char = e;code = 101
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = h;code = 104
char = y;code = 121
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char = v;code = 118
char = o;code = 111
char = l;code = 108
char = u;code = 117
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = n;code = 110
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char = 4;code = 52
char = 5;code = 53
char = );code = 41
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = a;code = 97
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char = d;code = 100
char = o;code = 111
char = m;code = 109
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = S;code = 83
char = D;code = 68
char = A;code = 65
char = -;code = 45
char = S;code = 83
char = B;code = 66
char = O;code = 79
char = ;code = 32
char = (;code = 40
char = 2;code = 50
char = 4;code = 52
char = ;code = 32
char = m;code = 109
char = l;code = 108
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char = d;code = 100
char = a;code = 97
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char = p;code = 112
char = r;code = 114
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char = p;code = 112
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char = a;code = 97
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char = 3;code = 51
char = .;code = 46
char = 7;code = 55
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char = g;code = 103
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char = D;code = 68
char = A;code = 65
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char = o;code = 111
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char = t;code = 116
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char = r;code = 114
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char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = S;code = 83
char = B;code = 66
char = O;code = 79
char = ;code = 32
char = (;code = 40
char = c;code = 99
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char = r;code = 114
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char = l;code = 108
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char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = );code = 41
char = ;code = 32
char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = o;code = 111
char = u;code = 117
char = t;code = 116
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char = r;code = 114
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = E;code = 69
char = P;code = 80
char = A;code = 65
char = ;code = 32
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = ;code = 32
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
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char = s;code = 115
char = ;code = 32
char = (;code = 40
char = a;code = 97
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char = p;code = 112
char = r;code = 114
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char = x;code = 120
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = l;code = 108
char = y;code = 121
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char = 1;code = 49
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char = /;code = 47
char = d;code = 100
char = a;code = 97
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char = );code = 41
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = 1;code = 49
char = 6;code = 54
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = k;code = 107
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = S;code = 83
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = l;code = 108
char = i;code = 105
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char = d;code = 100
char = s;code = 115
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char = ;code = 32
char = b;code = 98
char = l;code = 108
char = o;code = 111
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char = p;code = 112
char = r;code = 114
char = e;code = 101
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char = s;code = 115
char = u;code = 117
char = r;code = 114
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char = ;code = 32
char = h;code = 104
char = e;code = 101
char = a;code = 97
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char = t;code = 116
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char = r;code = 114
char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = p;code = 112
char = l;code = 108
char = a;code = 97
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char = e;code = 101
char = l;code = 108
char = e;code = 101
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char = ;code = 32
char = f;code = 102
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = s;code = 115
char = a;code = 97
char = f;code = 102
char = e;code = 101
char = t;code = 116
char = y;code = 121
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char = l;code = 108
char = a;code = 97
char = b;code = 98
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = y;code = 121
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char = t;code = 116
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = m;code = 109
char = e;code = 101
char = a;code = 97
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char = u;code = 117
char = r;code = 114
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char = ;code = 32
char = a;code = 97
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char = o;code = 111
char = n;code = 110
char = g;code = 103
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = o;code = 111
char = m;code = 109
char = e;code = 101
char = g;code = 103
char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = A;code = 65
char = ;code = 32
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char = r;code = 114
char = -;code = 45
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char = r;code = 114
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char = t;code = 116
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char = b;code = 98
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char = e;code = 101
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char = 1;code = 49
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char = r;code = 114
char = o;code = 111
char = u;code = 117
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char = .;code = 46
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char = C;code = 67
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char = p;code = 112
char = a;code = 97
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char = e;code = 101
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char = b;code = 98
char = a;code = 97
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char = e;code = 101
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char = i;code = 105
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char = e;code = 101
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char = g;code = 103
char = e;code = 101
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char = m;code = 109
char = e;code = 101
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char = a;code = 97
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char = e;code = 101
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char = i;code = 105
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char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
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char = 1;code = 49
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char = 5;code = 53
char = %;code = 37
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = S;code = 83
char = D;code = 68
char = A;code = 65
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
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char = d;code = 100
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char = 2;code = 50
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char = 4;code = 52
char = %;code = 37
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = E;code = 69
char = P;code = 80
char = A;code = 65
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = (;code = 40
char = p;code = 112
char = <;code = 60
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
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char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = b;code = 98
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = ,;code = 44
char = ;code = 32
char = v;code = 118
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char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = );code = 41
char = .;code = 46
char = ;code = 32
char = D;code = 68
char = H;code = 72
char = A;code = 65
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = y;code = 121
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char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = .;code = 46
char = ;code = 32
char = R;code = 82
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
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char = s;code = 115
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char = d;code = 100
char = ;code = 32
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char = h;code = 104
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char = m;code = 109
char = e;code = 101
char = g;code = 103
char = a;code = 97
char = -;code = 45
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char = i;code = 105
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result sql = A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA+DHA levels (the omega-3 index). Overweight healthy volunteers (n=45) were randomized to SDA-SBO (24 ml/day providing approximately 3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (approximately 1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p<0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs.
Publication: Lipids 2008 Sep ;43(9)::805-11. :doi: 10.1007/s11745-008-3215-0.
Publication Date: 2008 Sep
Study Author(s): Harris, William S;Lemke, Shawna L;Hansen, Susan N;Goldstein, Daniel A;DiRienzo, Maureen A;Su, Hong;Nemeth, Margaret A;Taylor, Mary L;Ahmed, Gulam;George, Cherian;
Institution: Sanford Research/USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA. [email protected]
Shortcut link to this study:
Publication Date: 2008 Sep
Study Author(s): Harris, William S;Lemke, Shawna L;Hansen, Susan N;Goldstein, Daniel A;DiRienzo, Maureen A;Su, Hong;Nemeth, Margaret A;Taylor, Mary L;Ahmed, Gulam;George, Cherian;
Institution: Sanford Research/USD, 1100 East 21st Street, Suite 700, Sioux Falls, SD 57105, USA. [email protected]
Shortcut link to this study:
A plant source of omega-3 fatty acid (FA) that can raise tissue eicosapentaenoic acid (EPA) and/or docosahexaenoic acid (DHA) is needed. A soybean oil (SBO) containing approximately 20% stearidonic acid [SDA; the delta-6 desaturase product of alpha-linolenic acid (ALA)] derived from genetically modified soybeans is under development. This study compared the effects of EPA to SDA-SBO on erythrocyte EPA+DHA levels (the omega-3 index). Overweight healthy volunteers (n=45) were randomized to SDA-SBO (24 ml/day providing approximately 3.7 g SDA) or to regular SBO (control group) without or with EPA ethyl esters (approximately 1 g/day) for 16 weeks. Serum lipids, blood pressure, heart rate, platelet function and safety laboratory tests were measured along with the omega-3 index. A per-protocol analysis was conducted on 33 subjects (11 per group). Compared to baseline, average omega-3 index levels increased 19.5% in the SDA group and 25.4% in the EPA group (p<0.05 for both, vs. control). DHA did not change in any group. Relative to EPA, SDA increased RBC EPA with about 17% efficiency. No other clinical endpoints were affected by SDA or EPA treatment (vs. control). In conclusion, SDA-enriched SBO significantly raised the omega-3 index. Since EPA supplementation has been shown to raise the omega-3 index and to lower risk for cardiac events, SDA-SBO may be a viable plant-based alternative for providing meaningful intakes of cardioprotective omega-3 FAs.
PMID: 18683001
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