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result sql = Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population.
Relationships between serum fatty acid composition and multiple markers of inflammation and endothelial function in an elderly population.
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char = ;code = 32
char = [;code = 91
char = T;code = 84
char = N;code = 78
char = F;code = 70
char = ];code = 93
char = -;code = 45
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = v;code = 118
char = a;code = 97
char = s;code = 115
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = m;code = 109
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = e;code = 101
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char = [;code = 91
char = V;code = 86
char = C;code = 67
char = A;code = 65
char = M;code = 77
char = ];code = 93
char = -;code = 45
char = 1;code = 49
char = ,;code = 44
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char = i;code = 105
char = n;code = 110
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char = r;code = 114
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char = e;code = 101
char = l;code = 108
char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = m;code = 109
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = [;code = 91
char = I;code = 73
char = C;code = 67
char = A;code = 65
char = M;code = 77
char = ];code = 93
char = -;code = 45
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = E;code = 69
char = -;code = 45
char = s;code = 115
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = P;code = 80
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char = s;code = 115
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = L;code = 76
char = -;code = 45
char = s;code = 115
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = e;code = 101
char = r;code = 114
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = n;code = 110
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char = g;code = 103
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = m;code = 109
char = o;code = 111
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char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = a;code = 97
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = a;code = 97
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = [;code = 91
char = M;code = 77
char = C;code = 67
char = P;code = 80
char = ];code = 93
char = -;code = 45
char = 1;code = 49
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = S;code = 83
char = C;code = 67
char = D;code = 68
char = -;code = 45
char = 1;code = 49
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = e;code = 101
char = s;code = 115
char = t;code = 116
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char = m;code = 109
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
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char = F;code = 70
char = A;code = 65
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = -;code = 45
char = t;code = 116
char = o;code = 111
char = -;code = 45
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = s;code = 115
char = o;code = 111
char = r;code = 114
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char = r;code = 114
char = a;code = 97
char = t;code = 116
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char = o;code = 111
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 6;code = 54
char = :;code = 58
char = 1;code = 49
char = /;code = 47
char = 1;code = 49
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char = :;code = 58
char = 0;code = 48
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char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = S;code = 83
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = F;code = 70
char = A;code = 65
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = C;code = 67
char = R;code = 82
char = P;code = 80
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = E;code = 69
char = -;code = 45
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char = e;code = 101
char = l;code = 108
char = e;code = 101
char = c;code = 99
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char = i;code = 105
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char = b;code = 98
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char = t;code = 116
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char = o;code = 111
char = t;code = 116
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
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char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = o;code = 111
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char = a;code = 97
char = r;code = 114
char = k;code = 107
char = e;code = 101
char = r;code = 114
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = f;code = 102
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = a;code = 97
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char = j;code = 106
char = u;code = 117
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = B;code = 66
char = M;code = 77
char = I;code = 73
char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = m;code = 109
char = o;code = 111
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char = g;code = 103
char = ,;code = 44
char = ;code = 32
char = p;code = 112
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char = c;code = 99
char = a;code = 97
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char = a;code = 97
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char = p;code = 112
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char = i;code = 105
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char = ;code = 32
char = a;code = 97
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char = c;code = 99
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char = a;code = 97
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char = d;code = 100
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = S;code = 83
char = C;code = 67
char = D;code = 68
char = -;code = 45
char = 1;code = 49
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char = i;code = 105
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char = e;code = 101
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char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = p;code = 112
char = o;code = 111
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char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = l;code = 108
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char = c;code = 99
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char = r;code = 114
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char = l;code = 108
char = a;code = 97
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char = C;code = 67
char = R;code = 82
char = P;code = 80
char = ;code = 32
char = c;code = 99
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char = c;code = 99
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char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = P;code = 80
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char = .;code = 46
char = 0;code = 48
char = 0;code = 48
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char = P;code = 80
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char = 0;code = 48
char = 1;code = 49
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char = <;code = 60
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char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = ;code = 32
char = :;code = 58
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char = <;code = 60
char = /;code = 47
char = b;code = 98
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char = A;code = 65
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char = F;code = 70
char = A;code = 65
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char = m;code = 109
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char = f;code = 102
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char = h;code = 104
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char = e;code = 101
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char = a;code = 97
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char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
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char = S;code = 83
char = C;code = 67
char = D;code = 68
char = -;code = 45
char = 1;code = 49
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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = C;code = 67
char = R;code = 82
char = P;code = 80
char = ;code = 32
char = c;code = 99
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char = n;code = 110
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char = b;code = 98
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char = o;code = 111
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char = h;code = 104
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char = m;code = 109
char = a;code = 97
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char = k;code = 107
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char = r;code = 114
char = s;code = 115
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char = o;code = 111
char = f;code = 102
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char = i;code = 105
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char = l;code = 108
char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = d;code = 100
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char = e;code = 101
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char = h;code = 104
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char = i;code = 105
char = a;code = 97
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char = f;code = 102
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
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result sql = BACKGROUND : Fatty acid (FA) composition in serum has been associated with C-reactive protein (CRP), but associations with other markers of inflammation and endothelial function, e.g. adhesion molecules are unknown. We recently suggested a possible role of the lipogenic enzyme stearoyl coenzymeA desaturase-1 (SCD-1) in inflammation. This study investigates the associations between serum FA composition, including SCD-1 index, and various inflammatory and endothelial function markers.

METHODS : 264 Swedish men and women aged 70 years participated in this cross-sectional population-based study. FA composition was measured in serum cholesteryl esters and was correlated to inflammatory markers (CRP, interleukin [IL]-2, IL-6, IL-8, tumor necrosis factor [TNF]-alpha, vascular cellular adhesion molecule [VCAM]-1, intercellular adhesion molecule [ICAM]-1, E-selectin, P-selectin, L-selectin, interferon-gamma, and monocyte chemoattractant protein [MCP]-1), using linear regression analysis. SCD-1 activity was estimated by FA product-to-precursor ratio (16:1/16:0).

RESULTS : Serum FA composition was significantly associated with CRP and E-selectin but not with other inflammatory markers. After adjusting for BMI, smoking, physical activity, alcohol consumption and lipid-lowering therapy, the proportion of palmitoleic acid and SCD-1 index were positively correlated with CRP concentrations (P=0.003 and P=0.001, respectively).

CONCLUSION : A FA composition reflecting high intake of saturated fat and a high SCD-1 index is independently related to CRP concentrations, but not to other markers of inflammation and endothelial function in this population of elderly men and women. Given the absent association between FA composition and the other markers, CRP may be the preferable marker to use when investigating potential relationships between FAs and low-grade inflammation.

Publication: Atherosclerosis 2009 Mar ;203(1)::298-303. :doi: 10.1016/j.atherosclerosis.2008.06.020.
Publication Date: 2009 Mar
Study Author(s): Petersson, Helena;Lind, Lars;Hulthe, Johannes;Elmgren, Anders;Cederholm, Tommy;Risérus, Ulf;
Institution: Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden. [email protected]
Shortcut link to this study:
BACKGROUND : Fatty acid (FA) composition in serum has been associated with C-reactive protein (CRP), but associations with other markers of inflammation and endothelial function, e.g. adhesion molecules are unknown. We recently suggested a possible role of the lipogenic enzyme stearoyl coenzymeA desaturase-1 (SCD-1) in inflammation. This study investigates the associations between serum FA composition, including SCD-1 index, and various inflammatory and endothelial function markers.

METHODS : 264 Swedish men and women aged 70 years participated in this cross-sectional population-based study. FA composition was measured in serum cholesteryl esters and was correlated to inflammatory markers (CRP, interleukin [IL]-2, IL-6, IL-8, tumor necrosis factor [TNF]-alpha, vascular cellular adhesion molecule [VCAM]-1, intercellular adhesion molecule [ICAM]-1, E-selectin, P-selectin, L-selectin, interferon-gamma, and monocyte chemoattractant protein [MCP]-1), using linear regression analysis. SCD-1 activity was estimated by FA product-to-precursor ratio (16:1/16:0).

RESULTS : Serum FA composition was significantly associated with CRP and E-selectin but not with other inflammatory markers. After adjusting for BMI, smoking, physical activity, alcohol consumption and lipid-lowering therapy, the proportion of palmitoleic acid and SCD-1 index were positively correlated with CRP concentrations (P=0.003 and P=0.001, respectively).

CONCLUSION : A FA composition reflecting high intake of saturated fat and a high SCD-1 index is independently related to CRP concentrations, but not to other markers of inflammation and endothelial function in this population of elderly men and women. Given the absent association between FA composition and the other markers, CRP may be the preferable marker to use when investigating potential relationships between FAs and low-grade inflammation.
PMID: 18687433

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