|
|
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result sql = Beneficial effects of carnosic acid on dieldrin-induced dopaminergic neuronal cell death.
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char = o;code = 111
char = t;code = 116
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result sql = Carnosic acid (CA) is one of the bioactive polyphenols present in extracts of the herb rosemary (Rosmarinus officinalis). In this study, we examined possible protective effects of CA on neurotoxicity induced by dieldrin, an organochlorine pesticide implicated in sporadic Parkinson's disease, in cultured dopaminergic cells (SN4741). CA (5-10 muM) pretreatment showed potent protective effects in a concentration-related manner and prevented dieldrin (10 muM)-induced caspase-3 activation, Jun N-terminal kinase phosphorylation, and caspase-12 activation. Furthermore, dieldrin-induced downregulation of brain-derived neurotrophic factor production was significantly attenuated by CA. These results suggest that CA may safeguard dopaminergic neuronal cells from environmental neurotoxins by enhancing brain-derived neurotrophic factor and repressing apoptotic molecules.
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = n;code = 110
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
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char = o;code = 111
char = n;code = 110
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char = d;code = 100
char = i;code = 105
char = e;code = 101
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = p;code = 112
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = r;code = 114
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char = c;code = 99
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char = e;code = 101
char = u;code = 117
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char = o;code = 111
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char = ;code = 32
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = .;code = 46
result sql = Beneficial effects of carnosic acid on dieldrin-induced dopaminergic neuronal cell death.
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result sql = Carnosic acid (CA) is one of the bioactive polyphenols present in extracts of the herb rosemary (Rosmarinus officinalis). In this study, we examined possible protective effects of CA on neurotoxicity induced by dieldrin, an organochlorine pesticide implicated in sporadic Parkinson's disease, in cultured dopaminergic cells (SN4741). CA (5-10 muM) pretreatment showed potent protective effects in a concentration-related manner and prevented dieldrin (10 muM)-induced caspase-3 activation, Jun N-terminal kinase phosphorylation, and caspase-12 activation. Furthermore, dieldrin-induced downregulation of brain-derived neurotrophic factor production was significantly attenuated by CA. These results suggest that CA may safeguard dopaminergic neuronal cells from environmental neurotoxins by enhancing brain-derived neurotrophic factor and repressing apoptotic molecules.
Publication: Neuroreport 2008 Aug 27 ;19(13)::1301-4. :doi: 10.1097/WNR.0b013e32830abc1f.
Publication Date: 2008 Aug 27
Study Author(s): Park, Jeong Ae;Kim, Seung;Lee, Sook-Young;Kim, Chun-Sung;Kim, Do Kyung;Kim, Sung-Jun;Chun, Hong Sung;
Institution: Department of Biotechnology (BK21 Program), College of Dentistry (BK21 Program), Chosun University, 375 Seosuk-dong, Gwangju, Republic of Korea.
Shortcut link to this study:
Publication Date: 2008 Aug 27
Study Author(s): Park, Jeong Ae;Kim, Seung;Lee, Sook-Young;Kim, Chun-Sung;Kim, Do Kyung;Kim, Sung-Jun;Chun, Hong Sung;
Institution: Department of Biotechnology (BK21 Program), College of Dentistry (BK21 Program), Chosun University, 375 Seosuk-dong, Gwangju, Republic of Korea.
Shortcut link to this study:
Carnosic acid (CA) is one of the bioactive polyphenols present in extracts of the herb rosemary (Rosmarinus officinalis). In this study, we examined possible protective effects of CA on neurotoxicity induced by dieldrin, an organochlorine pesticide implicated in sporadic Parkinson's disease, in cultured dopaminergic cells (SN4741). CA (5-10 muM) pretreatment showed potent protective effects in a concentration-related manner and prevented dieldrin (10 muM)-induced caspase-3 activation, Jun N-terminal kinase phosphorylation, and caspase-12 activation. Furthermore, dieldrin-induced downregulation of brain-derived neurotrophic factor production was significantly attenuated by CA. These results suggest that CA may safeguard dopaminergic neuronal cells from environmental neurotoxins by enhancing brain-derived neurotrophic factor and repressing apoptotic molecules.
PMID: 18695511
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