char = C;code = 67
Ceftriaxone-induced fixed drug eruption: first report.char = F;code = 70
Publication: Am J Clin Dermatol 2008 ;9(5)::345-7.
Publication Date: 2008
Study Author(s): Ozkaya, Esen;Mirzoyeva, Leyla;Jhaish, Mohammed S H;
Institution: Department of Dermatology, Istanbul Medical Faculty, Istanbul University, Capa-Istanbul, Turkey.
[email protected]
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Fixed drug eruption (FDE) is an unusual type of cutaneous adverse drug reaction that is characterized by recurrent site-specific lesions each time the drug responsible is taken. FDE from cephalosporins has been rarely reported, and to the best of our knowledge there is no published report of ceftriaxone-induced FDE in the literature. We report the first case of a 54-year-old Turkish woman who presented with ceftriaxone-induced FDE. Topical provocation with ceftriaxone sodium salt (1% in water [aq.], 5% aq., 10% in petrolatum [pet.], 20% pet.) remained negative both at previously affected sites and in the unaffected skin of the back. Therapeutic re-exposure with intravenous ceftriaxone 1 g confirmed the diagnosis. The patient tolerated amoxicillin and cefazolin, suggesting that the sensitizing portion was not the beta-lactam ring. Identification of the antigenic determinants of FDE-inducing drugs will make predicting safe alternatives in patients with FDE an easier task.
PMID: 18717612
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