|
|
char = G;code = 71
char = r;code = 114
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char = w;code = 119
char = t;code = 116
char = h;code = 104
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char = p;code = 112
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char = p;code = 112
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char = o;code = 111
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char = i;code = 105
char = s;code = 115
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char = i;code = 105
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char = c;code = 99
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char = i;code = 105
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char = s;code = 115
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char = r;code = 114
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char = l;code = 108
char = l;code = 108
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char = ;code = 32
char = n;code = 110
char = o;code = 111
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char = N;code = 78
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char = -;code = 45
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char = p;code = 112
char = a;code = 97
char = B;code = 66
char = ;code = 32
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char = n;code = 110
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char = i;code = 105
char = b;code = 98
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char = h;code = 104
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char = D;code = 68
char = H;code = 72
char = M;code = 77
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char = Q;code = 81
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char = .;code = 46
result sql = Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ).
Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ).char = S;code = 83
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char = v;code = 118
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char = a;code = 97
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char = s;code = 115
char = a;code = 97
char = r;code = 114
char = c;code = 99
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char = m;code = 109
char = a;code = 97
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
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char = m;code = 109
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char = o;code = 111
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char = t;code = 116
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char = s;code = 115
char = s;code = 115
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char = e;code = 101
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char = s;code = 115
char = a;code = 97
char = r;code = 114
char = c;code = 99
char = o;code = 111
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char = a;code = 97
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char = w;code = 119
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char = a;code = 97
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char = g;code = 103
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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
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char = ;code = 32
char = A;code = 65
char = l;code = 108
char = t;code = 116
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char = g;code = 103
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char = ;code = 32
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char = r;code = 114
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char = r;code = 114
char = y;code = 121
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char = r;code = 114
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char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = m;code = 109
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char = d;code = 100
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char = e;code = 101
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char = s;code = 115
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char = p;code = 112
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char = B;code = 66
char = ;code = 32
char = (;code = 40
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char = k;code = 107
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char = c;code = 99
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char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = a;code = 97
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char = h;code = 104
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = e;code = 101
char = m;code = 109
char = e;code = 101
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char = e;code = 101
char = d;code = 100
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char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
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char = e;code = 101
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char = i;code = 105
char = a;code = 97
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char = ;code = 32
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char = a;code = 97
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char = u;code = 117
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char = a;code = 97
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char = ;;code = 59
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char = h;code = 104
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char = e;code = 101
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char = p;code = 112
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char = s;code = 115
char = i;code = 105
char = b;code = 98
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char = d;code = 100
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char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
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char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
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char = l;code = 108
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = p;code = 112
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char = u;code = 117
char = t;code = 116
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char = g;code = 103
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char = t;code = 116
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = n;code = 110
char = o;code = 111
char = v;code = 118
char = i;code = 105
char = a;code = 97
char = l;code = 108
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char = s;code = 115
char = a;code = 97
char = r;code = 114
char = c;code = 99
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char = m;code = 109
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char = /;code = 47
char = >;code = 62
result sql = Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course. Although surgery is currently the first treatment modality, improvement of adjuvant chemotherapy is deemed essential to improve the clinical outcome. Nuclear factor-kappaB (NF-kappaB) is constitutively activated in various cancer cells and has emerged as a potential therapeutic molecular target; however, the possible involvement of NF-kappaB in the pathology of sarcomas remains to be clarified. Herein we examined the effects of a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) on two synovial sarcoma-derived cell lines, HS-SY-II and SYO-1. The growth of both cell lines was completely inhibited by DHMEQ and apoptosis was induced at 10 microg/ml. Additionally, we found that DHMEQ showed additive effects when used in combination with other cytotoxic agents. These observations indicate that inhibition of NF-kappaB activity may serve as a potential therapeutic target for synovial sarcoma.
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char = p;code = 112
char = p;code = 112
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char = s;code = 115
char = s;code = 115
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char = n;code = 110
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char = p;code = 112
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char = o;code = 111
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char = d;code = 100
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
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char = ;code = 32
char = s;code = 115
char = y;code = 121
char = n;code = 110
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char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = o;code = 111
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char = ;code = 32
char = d;code = 100
char = e;code = 101
char = h;code = 104
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char = r;code = 114
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char = x;code = 120
char = y;code = 121
char = m;code = 109
char = e;code = 101
char = t;code = 116
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char = l;code = 108
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char = p;code = 112
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char = u;code = 117
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char = D;code = 68
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char = M;code = 77
char = E;code = 69
char = Q;code = 81
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char = .;code = 46
result sql = Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ).
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char = ;code = 32
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char = e;code = 101
char = ;code = 32
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char = d;code = 100
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char = t;code = 116
char = i;code = 105
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char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = n;code = 110
char = o;code = 111
char = v;code = 118
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = a;code = 97
char = r;code = 114
char = c;code = 99
char = o;code = 111
char = m;code = 109
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result sql = Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course. Although surgery is currently the first treatment modality, improvement of adjuvant chemotherapy is deemed essential to improve the clinical outcome. Nuclear factor-kappaB (NF-kappaB) is constitutively activated in various cancer cells and has emerged as a potential therapeutic molecular target; however, the possible involvement of NF-kappaB in the pathology of sarcomas remains to be clarified. Herein we examined the effects of a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) on two synovial sarcoma-derived cell lines, HS-SY-II and SYO-1. The growth of both cell lines was completely inhibited by DHMEQ and apoptosis was induced at 10 microg/ml. Additionally, we found that DHMEQ showed additive effects when used in combination with other cytotoxic agents. These observations indicate that inhibition of NF-kappaB activity may serve as a potential therapeutic target for synovial sarcoma.
Publication: Cancer Lett. 2008 Dec 18 ;272(2)::336-44. :doi: 10.1016/j.canlet.2008.07.021.
Publication Date: 2008 Dec 18
Study Author(s): Horiuchi, Keisuke;Morioka, Hideo;Nishimoto, Kazumasa;Suzuki, Yoshihisa;Susa, Michiro;Nakayama, Robert;Kawai, Akira;Sonobe, Hiroshi;Takaishi, Hironari;Ozaki, Toshifumi;Yabe, Hiroo;Umezawa, Kazuo;Toyama, Yoshiaki;
Institution: Department of Orthopedic Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. [email protected]
Shortcut link to this study:
Publication Date: 2008 Dec 18
Study Author(s): Horiuchi, Keisuke;Morioka, Hideo;Nishimoto, Kazumasa;Suzuki, Yoshihisa;Susa, Michiro;Nakayama, Robert;Kawai, Akira;Sonobe, Hiroshi;Takaishi, Hironari;Ozaki, Toshifumi;Yabe, Hiroo;Umezawa, Kazuo;Toyama, Yoshiaki;
Institution: Department of Orthopedic Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. [email protected]
Shortcut link to this study:
Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course. Although surgery is currently the first treatment modality, improvement of adjuvant chemotherapy is deemed essential to improve the clinical outcome. Nuclear factor-kappaB (NF-kappaB) is constitutively activated in various cancer cells and has emerged as a potential therapeutic molecular target; however, the possible involvement of NF-kappaB in the pathology of sarcomas remains to be clarified. Herein we examined the effects of a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ) on two synovial sarcoma-derived cell lines, HS-SY-II and SYO-1. The growth of both cell lines was completely inhibited by DHMEQ and apoptosis was induced at 10 microg/ml. Additionally, we found that DHMEQ showed additive effects when used in combination with other cytotoxic agents. These observations indicate that inhibition of NF-kappaB activity may serve as a potential therapeutic target for synovial sarcoma.
PMID: 18760530
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