|
|
char = A;code = 65
char = c;code = 99
char = y;code = 121
char = l;code = 108
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = d;code = 100
char = o;code = 111
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = n;code = 110
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = i;code = 105
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
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char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
result sql = Acylamido analogs of endocannabinoids selectively inhibit cancer cell proliferation.
Acylamido analogs of endocannabinoids selectively inhibit cancer cell proliferation.char = A;code = 65
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = -;code = 45
char = c;code = 99
char = h;code = 104
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = d;code = 100
char = s;code = 115
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char = h;code = 104
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = e;code = 101
char = n;code = 110
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char = s;code = 115
char = t;code = 116
char = u;code = 117
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char = d;code = 100
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char = o;code = 111
char = r;code = 114
char = ;code = 32
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char = h;code = 104
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char = e;code = 101
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char = f;code = 102
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char = s;code = 115
char = ;code = 32
char = o;code = 111
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char = ;code = 32
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char = h;code = 104
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char = p;code = 112
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char = e;code = 101
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char = t;code = 116
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char = n;code = 110
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = .;code = 46
char = ;code = 32
char = F;code = 70
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = n;code = 110
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = l;code = 108
char = m;code = 109
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char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = h;code = 104
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char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = p;code = 112
char = o;code = 111
char = l;code = 108
char = y;code = 121
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char = n;code = 110
char = s;code = 115
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = y;code = 121
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = t;code = 116
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char = n;code = 110
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = 2;code = 50
char = 2;code = 50
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char = c;code = 99
char = a;code = 97
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char = b;code = 98
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char = n;code = 110
char = ;code = 32
char = a;code = 97
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char = m;code = 109
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = a;code = 97
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char = m;code = 109
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char = l;code = 108
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char = m;code = 109
char = o;code = 111
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char = i;code = 105
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char = s;code = 115
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char = d;code = 100
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char = a;code = 97
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char = ;code = 32
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char = l;code = 108
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char = l;code = 108
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char = e;code = 101
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char = u;code = 117
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char = d;code = 100
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char = r;code = 114
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
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char = ;code = 32
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char = t;code = 116
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char = ,;code = 44
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char = e;code = 101
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char = l;code = 108
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char = ,;code = 44
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char = H;code = 72
char = e;code = 101
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char = l;code = 108
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char = R;code = 82
char = A;code = 65
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char = b;code = 98
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char = ;code = 32
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char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = T;code = 84
char = B;code = 66
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char = l;code = 108
char = ;code = 32
char = l;code = 108
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char = ;code = 32
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char = a;code = 97
char = l;code = 108
char = m;code = 109
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char = t;code = 116
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char = l;code = 108
char = ;code = 32
char = d;code = 100
char = o;code = 111
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char = a;code = 97
char = m;code = 109
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char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = N;code = 78
char = -;code = 45
char = p;code = 112
char = a;code = 97
char = l;code = 108
char = m;code = 109
char = i;code = 105
char = t;code = 116
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char = l;code = 108
char = ;code = 32
char = t;code = 116
char = y;code = 121
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = n;code = 110
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char = e;code = 101
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char = c;code = 99
char = h;code = 104
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = m;code = 109
char = o;code = 111
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = s;code = 115
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char = e;code = 101
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char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = a;code = 97
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
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char = a;code = 97
char = t;code = 116
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char = ;code = 32
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char = M;code = 77
char = ;code = 32
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char = ;code = 32
char = w;code = 119
char = e;code = 101
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char = e;code = 101
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char = i;code = 105
char = g;code = 103
char = h;code = 104
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = e;code = 101
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char = ;code = 32
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char = ;code = 32
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char = u;code = 117
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char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
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char = p;code = 112
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char = t;code = 116
char = t;code = 116
char = e;code = 101
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char = n;code = 110
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char = c;code = 99
char = o;code = 111
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char = ;code = 32
char = b;code = 98
char = e;code = 101
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char = d;code = 100
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char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = t;code = 116
char = h;code = 104
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char = e;code = 101
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char = e;code = 101
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char = ;code = 32
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char = e;code = 101
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char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = o;code = 111
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char = ;code = 32
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char = m;code = 109
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = d;code = 100
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = y;code = 121
char = p;code = 112
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char = /;code = 47
char = >;code = 62
result sql = A series of amide derivatives of long-chain fatty acids has been studied for their effects on the proliferation of cancer cells in vitro. Fatty acids ranged from palmitic to higher polyunsaturated types containing 22 carbon atoms. The amino portions of the molecules included ammonia, ethanolamine, various amino acids and dopamine. Several cell lines were used as models and these included HTB-125 (normal human breast cells), HTB-126 (human breast cancer cells), HeLa (cervical cancer cells), WI-38 (human embryonic lung cells), RAW264.7 (mouse macrophage tumor cells) and RBL-2H3 (rat basophilic leukemia cells). The HTB lines were obtained from the same donor, so, could be considered a matched pair, that is, normal control versus cancer cells and thus, provide a model for testing specificity of action for the acylamido analogs. While many compounds were efficacious in inhibiting the proliferation of various cell lines, only two analogs showed a high degree of specificity in the matched HTB cell lines. N-palmitoyl dopamine and N-palmitoyl tyrosine each demonstrated complete specificity of action at a concentration of 10muM and were highly efficacious in both cases. No clear structure-activity pattern could be derived from these studies since the intensity of the inhibitory action seemed to depend on three factors, namely, the fatty acid, the amine group and the cell type.
char = c;code = 99
char = y;code = 121
char = l;code = 108
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = d;code = 100
char = o;code = 111
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = n;code = 110
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = i;code = 105
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
result sql = Acylamido analogs of endocannabinoids selectively inhibit cancer cell proliferation.
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char = o;code = 111
char = f;code = 102
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char = m;code = 109
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char = d;code = 100
char = e;code = 101
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char = v;code = 118
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = l;code = 108
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char = g;code = 103
char = -;code = 45
char = c;code = 99
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char = t;code = 116
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char = p;code = 112
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char = s;code = 115
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char = o;code = 111
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char = ;code = 32
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char = e;code = 101
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char = m;code = 109
char = o;code = 111
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char = c;code = 99
char = u;code = 117
char = l;code = 108
char = e;code = 101
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = c;code = 99
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char = e;code = 101
char = d;code = 100
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char = a;code = 97
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char = m;code = 109
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char = i;code = 105
char = a;code = 97
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char = e;code = 101
char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = o;code = 111
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char = a;code = 97
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char = i;code = 105
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char = ;code = 32
char = v;code = 118
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = o;code = 111
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char = s;code = 115
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char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = o;code = 111
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char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = s;code = 115
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = p;code = 112
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = .;code = 46
char = ;code = 32
char = S;code = 83
char = e;code = 101
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char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
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char = e;code = 101
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = u;code = 117
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = s;code = 115
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char = m;code = 109
char = o;code = 111
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char = e;code = 101
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = t;code = 116
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char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = H;code = 72
char = T;code = 84
char = B;code = 66
char = -;code = 45
char = 1;code = 49
char = 2;code = 50
char = 5;code = 53
char = ;code = 32
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char = n;code = 110
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = ,;code = 44
char = ;code = 32
char = H;code = 72
char = T;code = 84
char = B;code = 66
char = -;code = 45
char = 1;code = 49
char = 2;code = 50
char = 6;code = 54
char = ;code = 32
char = (;code = 40
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
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char = b;code = 98
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = ,;code = 44
char = ;code = 32
char = H;code = 72
char = e;code = 101
char = L;code = 76
char = a;code = 97
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char = (;code = 40
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = W;code = 87
char = I;code = 73
char = -;code = 45
char = 3;code = 51
char = 8;code = 56
char = ;code = 32
char = (;code = 40
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
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char = e;code = 101
char = m;code = 109
char = b;code = 98
char = r;code = 114
char = y;code = 121
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = l;code = 108
char = u;code = 117
char = n;code = 110
char = g;code = 103
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = ,;code = 44
char = ;code = 32
char = R;code = 82
char = A;code = 65
char = W;code = 87
char = 2;code = 50
char = 6;code = 54
char = 4;code = 52
char = .;code = 46
char = 7;code = 55
char = ;code = 32
char = (;code = 40
char = m;code = 109
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = e;code = 101
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char = m;code = 109
char = a;code = 97
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = );code = 41
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = R;code = 82
char = B;code = 66
char = L;code = 76
char = -;code = 45
char = 2;code = 50
char = H;code = 72
char = 3;code = 51
char = ;code = 32
char = (;code = 40
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = b;code = 98
char = a;code = 97
char = s;code = 115
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = c;code = 99
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char = l;code = 108
char = e;code = 101
char = u;code = 117
char = k;code = 107
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = a;code = 97
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = );code = 41
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = H;code = 72
char = T;code = 84
char = B;code = 66
char = ;code = 32
char = l;code = 108
char = i;code = 105
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char = e;code = 101
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = o;code = 111
char = b;code = 98
char = t;code = 116
char = a;code = 97
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char = n;code = 110
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char = d;code = 100
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char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = s;code = 115
char = a;code = 97
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char = e;code = 101
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char = o;code = 111
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char = o;code = 111
char = ,;code = 44
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char = c;code = 99
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char = c;code = 99
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char = e;code = 101
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char = e;code = 101
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char = m;code = 109
char = a;code = 97
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char = c;code = 99
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char = e;code = 101
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char = a;code = 97
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char = r;code = 114
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char = a;code = 97
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char = i;code = 105
char = s;code = 115
char = ,;code = 44
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char = a;code = 97
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char = o;code = 111
char = l;code = 108
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char = s;code = 115
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char = c;code = 99
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char = c;code = 99
char = e;code = 101
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = a;code = 97
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char = d;code = 100
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char = t;code = 116
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char = s;code = 115
char = ,;code = 44
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char = o;code = 111
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = t;code = 116
char = e;code = 101
char = s;code = 115
char = t;code = 116
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char = n;code = 110
char = g;code = 103
char = ;code = 32
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char = e;code = 101
char = c;code = 99
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = t;code = 116
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char = a;code = 97
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char = i;code = 105
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char = r;code = 114
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char = t;code = 116
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char = e;code = 101
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char = a;code = 97
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char = a;code = 97
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char = a;code = 97
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = e;code = 101
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char = m;code = 109
char = a;code = 97
char = n;code = 110
char = y;code = 121
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char = c;code = 99
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char = m;code = 109
char = p;code = 112
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char = u;code = 117
char = n;code = 110
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = c;code = 99
char = i;code = 105
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char = s;code = 115
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char = i;code = 105
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char = h;code = 104
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char = b;code = 98
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char = t;code = 116
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char = h;code = 104
char = e;code = 101
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char = r;code = 114
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char = f;code = 102
char = e;code = 101
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char = a;code = 97
char = t;code = 116
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char = o;code = 111
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char = o;code = 111
char = u;code = 117
char = s;code = 115
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char = l;code = 108
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char = H;code = 72
char = T;code = 84
char = B;code = 66
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char = l;code = 108
char = l;code = 108
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char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
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char = ;code = 32
char = N;code = 78
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char = p;code = 112
char = a;code = 97
char = l;code = 108
char = m;code = 109
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char = t;code = 116
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char = a;code = 97
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char = n;code = 110
char = e;code = 101
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char = a;code = 97
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char = d;code = 100
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char = N;code = 78
char = -;code = 45
char = p;code = 112
char = a;code = 97
char = l;code = 108
char = m;code = 109
char = i;code = 105
char = t;code = 116
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char = e;code = 101
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char = a;code = 97
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char = m;code = 109
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char = e;code = 101
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char = e;code = 101
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char = s;code = 115
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char = e;code = 101
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char = f;code = 102
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char = t;code = 116
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char = o;code = 111
char = f;code = 102
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char = a;code = 97
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char = t;code = 116
char = i;code = 105
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char = ;code = 32
char = a;code = 97
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char = c;code = 99
char = o;code = 111
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char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 1;code = 49
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char = m;code = 109
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char = M;code = 77
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
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char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = l;code = 108
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char = e;code = 101
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = o;code = 111
char = u;code = 117
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = o;code = 111
char = t;code = 116
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result sql = A series of amide derivatives of long-chain fatty acids has been studied for their effects on the proliferation of cancer cells in vitro. Fatty acids ranged from palmitic to higher polyunsaturated types containing 22 carbon atoms. The amino portions of the molecules included ammonia, ethanolamine, various amino acids and dopamine. Several cell lines were used as models and these included HTB-125 (normal human breast cells), HTB-126 (human breast cancer cells), HeLa (cervical cancer cells), WI-38 (human embryonic lung cells), RAW264.7 (mouse macrophage tumor cells) and RBL-2H3 (rat basophilic leukemia cells). The HTB lines were obtained from the same donor, so, could be considered a matched pair, that is, normal control versus cancer cells and thus, provide a model for testing specificity of action for the acylamido analogs. While many compounds were efficacious in inhibiting the proliferation of various cell lines, only two analogs showed a high degree of specificity in the matched HTB cell lines. N-palmitoyl dopamine and N-palmitoyl tyrosine each demonstrated complete specificity of action at a concentration of 10muM and were highly efficacious in both cases. No clear structure-activity pattern could be derived from these studies since the intensity of the inhibitory action seemed to depend on three factors, namely, the fatty acid, the amine group and the cell type.
Publication: Bioorg. Med. Chem. 2008 Nov 15 ;16(22)::9644-51. :doi: 10.1016/j.bmc.2008.10.015.
Publication Date: 2008 Nov 15
Study Author(s): Burstein, Sumner;Salmonsen, Rebecca;
Institution: Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, Worcester, MA 01605, USA. [email protected]
Shortcut link to this study:
Publication Date: 2008 Nov 15
Study Author(s): Burstein, Sumner;Salmonsen, Rebecca;
Institution: Department of Biochemistry and Molecular Pharmacology, The University of Massachusetts Medical School, Worcester, MA 01605, USA. [email protected]
Shortcut link to this study:
A series of amide derivatives of long-chain fatty acids has been studied for their effects on the proliferation of cancer cells in vitro. Fatty acids ranged from palmitic to higher polyunsaturated types containing 22 carbon atoms. The amino portions of the molecules included ammonia, ethanolamine, various amino acids and dopamine. Several cell lines were used as models and these included HTB-125 (normal human breast cells), HTB-126 (human breast cancer cells), HeLa (cervical cancer cells), WI-38 (human embryonic lung cells), RAW264.7 (mouse macrophage tumor cells) and RBL-2H3 (rat basophilic leukemia cells). The HTB lines were obtained from the same donor, so, could be considered a matched pair, that is, normal control versus cancer cells and thus, provide a model for testing specificity of action for the acylamido analogs. While many compounds were efficacious in inhibiting the proliferation of various cell lines, only two analogs showed a high degree of specificity in the matched HTB cell lines. N-palmitoyl dopamine and N-palmitoyl tyrosine each demonstrated complete specificity of action at a concentration of 10muM and were highly efficacious in both cases. No clear structure-activity pattern could be derived from these studies since the intensity of the inhibitory action seemed to depend on three factors, namely, the fatty acid, the amine group and the cell type.
PMID: 18951802
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