char = L;code = 76
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char = ;code = 32
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char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = s;code = 115
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char = g;code = 103
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char = a;code = 97
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char = e;code = 101
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char = a;code = 97
char = n;code = 110
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char = e;code = 101
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = r;code = 114
char = a;code = 97
char = b;code = 98
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Lack of effect of sugar cane and sunflower seed policosanols on plasma cholesterol in rabbits.
Lack of effect of sugar cane and sunflower seed policosanols on plasma cholesterol in rabbits.
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = O;code = 79
char = B;code = 66
char = J;code = 74
char = E;code = 69
char = C;code = 67
char = T;code = 84
char = I;code = 73
char = V;code = 86
char = E;code = 69
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
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char = T;code = 84
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char = v;code = 118
char = a;code = 97
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char = u;code = 117
char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = p;code = 112
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = l;code = 108
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = x;code = 120
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
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char = l;code = 108
char = i;code = 105
char = c;code = 99
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char = s;code = 115
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char = o;code = 111
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char = e;code = 101
char = x;code = 120
char = t;code = 116
char = r;code = 114
char = a;code = 97
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char = d;code = 100
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char = w;code = 119
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char = o;code = 111
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char = l;code = 108
char = ;code = 32
char = (;code = 40
char = S;code = 83
char = F;code = 70
char = P;code = 80
char = );code = 41
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = r;code = 114
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char = b;code = 98
char = l;code = 108
char = o;code = 111
char = o;code = 111
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char = ;code = 32
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = g;code = 103
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = e;code = 101
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char = l;code = 108
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char = c;code = 99
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char = a;code = 97
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char = S;code = 83
char = C;code = 67
char = P;code = 80
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char = i;code = 105
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char = a;code = 97
char = b;code = 98
char = b;code = 98
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char = t;code = 116
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
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char = <;code = 60
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char = D;code = 68
char = E;code = 69
char = S;code = 83
char = I;code = 73
char = G;code = 71
char = N;code = 78
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = T;code = 84
char = w;code = 119
char = e;code = 101
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char = y;code = 121
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char = t;code = 116
char = h;code = 104
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char = e;code = 101
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char = S;code = 83
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char = b;code = 98
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = b;code = 98
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char = c;code = 99
char = k;code = 107
char = e;code = 101
char = d;code = 100
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char = o;code = 111
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char = t;code = 116
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char = e;code = 101
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
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char = p;code = 112
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = d;code = 100
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char = ;code = 32
char = f;code = 102
char = a;code = 97
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char = p;code = 112
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char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = c;code = 99
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char = o;code = 111
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = r;code = 114
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = o;code = 111
char = m;code = 109
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
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char = g;code = 103
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char = e;code = 101
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char = ;code = 32
char = o;code = 111
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char = f;code = 102
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char = e;code = 101
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char = a;code = 97
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char = a;code = 97
char = l;code = 108
char = l;code = 108
char = e;code = 101
char = l;code = 108
char = ;code = 32
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char = e;code = 101
char = a;code = 97
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char = m;code = 109
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char = n;code = 110
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char = ;code = 32
char = a;code = 97
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char = m;code = 109
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char = :;code = 58
char = ;code = 32
char = C;code = 67
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char = n;code = 110
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = (;code = 40
char = V;code = 86
char = e;code = 101
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = l;code = 108
char = e;code = 101
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char = 2;code = 50
char = 8;code = 56
char = .;code = 46
char = 6;code = 54
char = %;code = 37
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char = s;code = 115
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char = e;code = 101
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char = i;code = 105
char = l;code = 108
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char = a;code = 97
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char = e;code = 101
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char = 1;code = 49
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char = 4;code = 52
char = %;code = 37
char = ;code = 32
char = e;code = 101
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char = i;code = 105
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char = ;code = 32
char = n;code = 110
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char = =;code = 61
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char = 7;code = 55
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char = S;code = 83
char = F;code = 70
char = P;code = 80
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char = 0;code = 48
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char = =;code = 61
char = ;code = 32
char = 8;code = 56
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char = S;code = 83
char = C;code = 67
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char = 0;code = 48
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char = ;code = 32
char = R;code = 82
char = a;code = 97
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char = b;code = 98
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char = e;code = 101
char = k;code = 107
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char = B;code = 66
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char = <;code = 60
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char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
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char = o;code = 111
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char = a;code = 97
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char = c;code = 99
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char = a;code = 97
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char = H;code = 72
char = D;code = 68
char = L;code = 76
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char = c;code = 99
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result sql = OBJECTIVE : To evaluate the potential for a mixture of policosanol extracted from sunflower oil (SFP) to lower blood cholesterol levels in comparison to sugar cane policosanol (SCP) in rabbits.

DESIGN : Twenty three Semi-lop rabbits were blocked into three groups matched on fasting plasma cholesterol levels then randomly assigned to one of three parallel treatment arms: Control (Vehicle 28.6% sunflower oil/70% water/1.4% emulsifier) n = 7; SFP, 100 mg/kg in vehicle, n = 8; SCP, 100 mg/kg in vehicle, n = 8. Rabbits were gavaged once every two days for four weeks. Blood was collected and analysed for plasma lipids.

RESULTS : Total cholesterol, non-HDL and HDL cholesterol increased significantly following SCP supplementation relative to the control. SFP supplementation had no effect. Triglyceride levels decreased significantly following all dietary treatments (P < 0.05), possibly due to the emulsifier.

CONCLUSION : Dietary supplementation of normocholesterolemic rabbits with policosanol from sunflower oil does not appear to have any cholesterol lowering effect. A similar lack of efficacy observed with the commercial SCP product which we evaluated raises doubts about the purported cholesterol-lowering efficacy of these products, as reflected in the current literature.

Publication: J Am Coll Nutr 2008 Aug ;27(4)::476-84.
Publication Date: 2008 Aug
Study Author(s): Murphy, Karen J;Saint, David A;Howe, Peter R C;
Institution: Nutritional Physiology Research Centre, School of Health Sciences, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia. karen.murphy@unisa.edu.au
Shortcut link to this study:
OBJECTIVE : To evaluate the potential for a mixture of policosanol extracted from sunflower oil (SFP) to lower blood cholesterol levels in comparison to sugar cane policosanol (SCP) in rabbits.

DESIGN : Twenty three Semi-lop rabbits were blocked into three groups matched on fasting plasma cholesterol levels then randomly assigned to one of three parallel treatment arms: Control (Vehicle 28.6% sunflower oil/70% water/1.4% emulsifier) n = 7; SFP, 100 mg/kg in vehicle, n = 8; SCP, 100 mg/kg in vehicle, n = 8. Rabbits were gavaged once every two days for four weeks. Blood was collected and analysed for plasma lipids.

RESULTS : Total cholesterol, non-HDL and HDL cholesterol increased significantly following SCP supplementation relative to the control. SFP supplementation had no effect. Triglyceride levels decreased significantly following all dietary treatments (P < 0.05), possibly due to the emulsifier.

CONCLUSION : Dietary supplementation of normocholesterolemic rabbits with policosanol from sunflower oil does not appear to have any cholesterol lowering effect. A similar lack of efficacy observed with the commercial SCP product which we evaluated raises doubts about the purported cholesterol-lowering efficacy of these products, as reflected in the current literature.
PMID: 18978167

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