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result sql = We investigated magnetic resonance imaging T2-star (MRI-T2*) values and left ventricular ejection fraction (LVEF) in 7 adult patients with bone marrow failure with heavy transfusion to elucidate the correlation between cardiac iron overload and dysfunction. We demonstrated a positive correlation between the total volume of red blood cells (RBC) transfusion and ejection fraction. The normal T2* limit value, which represents cardiac siderosis, is probably 200 mL/kg RBC transfusion. Patients with serum ferritin levels of under 5000 ng/mL and who received 200-400 mL/kg RBC transfusion showed mild but progressive decrease of the T2* value without obvious reduction of the ejection fraction, indicating that the T2* value of MRI could be a predictor for cardiac iron deposition before the appearance of myocardial dysfunction. Transfused RBC amount of >400 mL/kg or rapid elevation of ferritin level of >5000 ng/mL might be warning sign for critical cardiac dysfunction. Since iron overload of the heart is a major factor affecting co-morbidity of bone marrow failure, MRI evaluation of cardiac iron overload and functional disturbance in adult non-thalassemic patients is essential.
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result sql = Evaluation of cardiac iron overload in transfusion-dependent adult marrow failure patients by magnetic resonance imaging.
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char = o;code = 111
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char = r;code = 114
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char = t;code = 116
char = i;code = 105
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char = o;code = 111
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char = f;code = 102
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char = n;code = 110
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char = ;code = 32
char = d;code = 100
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char = s;code = 115
char = t;code = 116
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char = n;code = 110
char = ;code = 32
char = a;code = 97
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char = e;code = 101
char = n;code = 110
char = t;code = 116
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char = s;code = 115
char = ;code = 32
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char = s;code = 115
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
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result sql = We investigated magnetic resonance imaging T2-star (MRI-T2*) values and left ventricular ejection fraction (LVEF) in 7 adult patients with bone marrow failure with heavy transfusion to elucidate the correlation between cardiac iron overload and dysfunction. We demonstrated a positive correlation between the total volume of red blood cells (RBC) transfusion and ejection fraction. The normal T2* limit value, which represents cardiac siderosis, is probably 200 mL/kg RBC transfusion. Patients with serum ferritin levels of under 5000 ng/mL and who received 200-400 mL/kg RBC transfusion showed mild but progressive decrease of the T2* value without obvious reduction of the ejection fraction, indicating that the T2* value of MRI could be a predictor for cardiac iron deposition before the appearance of myocardial dysfunction. Transfused RBC amount of >400 mL/kg or rapid elevation of ferritin level of >5000 ng/mL might be warning sign for critical cardiac dysfunction. Since iron overload of the heart is a major factor affecting co-morbidity of bone marrow failure, MRI evaluation of cardiac iron overload and functional disturbance in adult non-thalassemic patients is essential.
Publication: Leuk. Res. 2009 Jun ;33(6)::756-8. :doi: 10.1016/j.leukres.2008.10.018.
Publication Date: 2009 Jun
Study Author(s): Park, Jinho;Ohyashiki, Kazuma;Akata, Soichi;Takara, Kenichi;Uno, Ritsuko;Kakizaki, Dai;Miyazawa, Keisuke;Kimura, Yukihiko;Tokuuye, Koichi;
Institution: Department of Radiology, Tokyo Medical University, Tokyo, Japan.
Shortcut link to this study:
Publication Date: 2009 Jun
Study Author(s): Park, Jinho;Ohyashiki, Kazuma;Akata, Soichi;Takara, Kenichi;Uno, Ritsuko;Kakizaki, Dai;Miyazawa, Keisuke;Kimura, Yukihiko;Tokuuye, Koichi;
Institution: Department of Radiology, Tokyo Medical University, Tokyo, Japan.
Shortcut link to this study:
We investigated magnetic resonance imaging T2-star (MRI-T2*) values and left ventricular ejection fraction (LVEF) in 7 adult patients with bone marrow failure with heavy transfusion to elucidate the correlation between cardiac iron overload and dysfunction. We demonstrated a positive correlation between the total volume of red blood cells (RBC) transfusion and ejection fraction. The normal T2* limit value, which represents cardiac siderosis, is probably 200 mL/kg RBC transfusion. Patients with serum ferritin levels of under 5000 ng/mL and who received 200-400 mL/kg RBC transfusion showed mild but progressive decrease of the T2* value without obvious reduction of the ejection fraction, indicating that the T2* value of MRI could be a predictor for cardiac iron deposition before the appearance of myocardial dysfunction. Transfused RBC amount of >400 mL/kg or rapid elevation of ferritin level of >5000 ng/mL might be warning sign for critical cardiac dysfunction. Since iron overload of the heart is a major factor affecting co-morbidity of bone marrow failure, MRI evaluation of cardiac iron overload and functional disturbance in adult non-thalassemic patients is essential.
PMID: 19038447
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