|
|
char = C;code = 67
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = P;code = 80
char = G;code = 71
char = E;code = 69
char = 2;code = 50
char = ;code = 32
char = a;code = 97
char = f;code = 102
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = b;code = 98
char = u;code = 117
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = f;code = 102
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = r;code = 114
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char = a;code = 97
char = t;code = 116
char = m;code = 109
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char = n;code = 110
char = t;code = 116
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = f;code = 102
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = d;code = 100
char = u;code = 117
char = c;code = 99
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char = u;code = 117
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = s;code = 115
char = u;code = 117
char = s;code = 115
char = .;code = 46
result sql = Changes in urinary PGE2 after ibuprofen treatment in preterm infants with patent ductus arteriosus.
Changes in urinary PGE2 after ibuprofen treatment in preterm infants with patent ductus arteriosus.char = <;code = 60
char = b;code = 98
char = >;code = 62
char = P;code = 80
char = U;code = 85
char = R;code = 82
char = P;code = 80
char = O;code = 79
char = S;code = 83
char = E;code = 69
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = T;code = 84
char = o;code = 111
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = v;code = 118
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = P;code = 80
char = G;code = 71
char = E;code = 69
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = a;code = 97
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char = e;code = 101
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char = i;code = 105
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char = r;code = 114
char = o;code = 111
char = f;code = 102
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
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char = t;code = 116
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char = i;code = 105
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char = t;code = 116
char = e;code = 101
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char = m;code = 109
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char = n;code = 110
char = f;code = 102
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = d;code = 100
char = u;code = 117
char = c;code = 99
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char = u;code = 117
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char = ;code = 32
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char = e;code = 101
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char = i;code = 105
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char = s;code = 115
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = D;code = 68
char = A;code = 65
char = );code = 41
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = M;code = 77
char = E;code = 69
char = T;code = 84
char = H;code = 72
char = O;code = 79
char = D;code = 68
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = T;code = 84
char = w;code = 119
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = y;code = 121
char = ;code = 32
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char = e;code = 101
char = t;code = 116
char = e;code = 101
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char = m;code = 109
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char = f;code = 102
char = a;code = 97
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char = i;code = 105
char = t;code = 116
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char = ;code = 32
char = h;code = 104
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char = m;code = 109
char = o;code = 111
char = d;code = 100
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char = a;code = 97
char = m;code = 109
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char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
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char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = P;code = 80
char = D;code = 68
char = A;code = 65
char = ;code = 32
char = (;code = 40
char = g;code = 103
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char = s;code = 115
char = t;code = 116
char = a;code = 97
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char = i;code = 105
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char = a;code = 97
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char = 2;code = 50
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char = 2;code = 50
char = .;code = 46
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char = w;code = 119
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char = e;code = 101
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char = );code = 41
char = ;code = 32
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char = r;code = 114
char = o;code = 111
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char = ;code = 32
char = (;code = 40
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = g;code = 103
char = e;code = 101
char = ,;code = 44
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char = 3;code = 51
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char = .;code = 46
char = 4;code = 52
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char = +;code = 43
char = /;code = 47
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char = 1;code = 49
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char = 5;code = 53
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char = e;code = 101
char = e;code = 101
char = k;code = 107
char = s;code = 115
char = );code = 41
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
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char = p;code = 112
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char = c;code = 99
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char = e;code = 101
char = l;code = 108
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char = ;code = 32
char = e;code = 101
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char = r;code = 114
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = 4;code = 52
char = 8;code = 56
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char = 7;code = 55
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char = ;code = 32
char = h;code = 104
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char = l;code = 108
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char = .;code = 46
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char = A;code = 65
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char = e;code = 101
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char = o;code = 111
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char = m;code = 109
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char = ,;code = 44
char = ;code = 32
char = t;code = 116
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char = w;code = 119
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = c;code = 99
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char = n;code = 110
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char = e;code = 101
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char = t;code = 116
char = i;code = 105
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char = a;code = 97
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char = );code = 41
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char = (;code = 40
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char = (;code = 40
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char = );code = 41
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char = R;code = 82
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char = S;code = 83
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char = T;code = 84
char = S;code = 83
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char = ;code = 32
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char = ;code = 32
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char = 0;code = 48
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char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = (;code = 40
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char = o;code = 111
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char = e;code = 101
char = v;code = 118
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char = ;code = 32
char = u;code = 117
char = r;code = 114
char = i;code = 105
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char = r;code = 114
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char = ;code = 32
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char = (;code = 40
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char = );code = 41
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = T;code = 84
char = (;code = 40
char = 1;code = 49
char = );code = 41
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
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char = g;code = 103
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char = f;code = 102
char = i;code = 105
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char = 0;code = 48
char = 1;code = 49
char = );code = 41
char = ;code = 32
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char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = b;code = 98
char = u;code = 117
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = f;code = 102
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = g;code = 103
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char = o;code = 111
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char = u;code = 117
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char = l;code = 108
char = ;code = 32
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char = c;code = 99
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char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
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char = r;code = 114
char = e;code = 101
char = e;code = 101
char = ;code = 32
char = i;code = 105
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char = <;code = 60
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char = C;code = 67
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char = U;code = 85
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char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
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char = :;code = 58
char = ;code = 32
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char = G;code = 71
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char = (;code = 40
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = t;code = 116
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char = r;code = 114
char = ;code = 32
char = r;code = 114
char = e;code = 101
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char = a;code = 97
char = l;code = 108
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char = f;code = 102
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char = c;code = 99
char = t;code = 116
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char = o;code = 111
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result sql = PURPOSE : To investigate changes in urinary PGE(2) after ibuprofen treatment in preterm infants with patent ductus arteriosus (PDA).
METHODS : Twenty preterm infants with a hemodynamically significant PDA (gestational age, 28.6 +/- 2.3 weeks) and 20 controls (gestational age, 30.4 +/- 1.5 weeks) were prospectively enrolled at 48-72 h of life. After enrollment, the former underwent conventional ibuprofen-lysine treatment. At 48-72 h (T(0)) and 108-144 h of life (T(1)), urine samples were noninvasively collected in both groups to measure urinary PGE(2) concentrations (enzyme immunoassay method), and renal function was investigated.
RESULTS : Urinary PGE(2) decreased significantly both in ibuprofen-treated patients (66.95 +/- 16.78 vs. 27.15 +/- 17.92 pg/mL, P < 0.001) and in controls (71.7 +/- 16.2 vs. 53.2 +/- 18.4 pg/mL, P < 0.001) from T(0) to T(1). However, urinary PGE(2) at T(1) was significantly lower (P < 0.001) in the ibuprofen group compared to the control group. Acute renal failure occurred in three ibuprofen-treated patients (15%).
CONCLUSIONS : Ibuprofen markedly reduces (59.4%) urinary PGE(2) and may alter renal function in the newborn.
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result sql = Changes in urinary PGE2 after ibuprofen treatment in preterm infants with patent ductus arteriosus.
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char = .;code = 46
char = 7;code = 55
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char = ;code = 32
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char = 2;code = 50
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char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
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char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 1;code = 49
char = );code = 41
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = (;code = 40
char = 0;code = 48
char = );code = 41
char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = T;code = 84
char = (;code = 40
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char = );code = 41
char = .;code = 46
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char = r;code = 114
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char = r;code = 114
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char = P;code = 80
char = G;code = 71
char = E;code = 69
char = (;code = 40
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char = );code = 41
char = ;code = 32
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char = t;code = 116
char = ;code = 32
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char = );code = 41
char = ;code = 32
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char = a;code = 97
char = s;code = 115
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char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = n;code = 110
char = t;code = 116
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char = y;code = 121
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char = l;code = 108
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = 0;code = 48
char = .;code = 46
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char = 0;code = 48
char = 1;code = 49
char = );code = 41
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = b;code = 98
char = u;code = 117
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = f;code = 102
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = c;code = 99
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = i;code = 105
char = l;code = 108
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = c;code = 99
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = e;code = 101
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = b;code = 98
char = u;code = 117
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = f;code = 102
char = e;code = 101
char = n;code = 110
char = -;code = 45
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 5;code = 53
char = %;code = 37
char = );code = 41
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = C;code = 67
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char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
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char = >;code = 62
char = I;code = 73
char = b;code = 98
char = u;code = 117
char = p;code = 112
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char = o;code = 111
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char = k;code = 107
char = e;code = 101
char = d;code = 100
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = 5;code = 53
char = 9;code = 57
char = .;code = 46
char = 4;code = 52
char = %;code = 37
char = );code = 41
char = ;code = 32
char = u;code = 117
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = P;code = 80
char = G;code = 71
char = E;code = 69
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = f;code = 102
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = w;code = 119
char = b;code = 98
char = o;code = 111
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char = n;code = 110
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result sql = PURPOSE : To investigate changes in urinary PGE(2) after ibuprofen treatment in preterm infants with patent ductus arteriosus (PDA).
METHODS : Twenty preterm infants with a hemodynamically significant PDA (gestational age, 28.6 +/- 2.3 weeks) and 20 controls (gestational age, 30.4 +/- 1.5 weeks) were prospectively enrolled at 48-72 h of life. After enrollment, the former underwent conventional ibuprofen-lysine treatment. At 48-72 h (T(0)) and 108-144 h of life (T(1)), urine samples were noninvasively collected in both groups to measure urinary PGE(2) concentrations (enzyme immunoassay method), and renal function was investigated.
RESULTS : Urinary PGE(2) decreased significantly both in ibuprofen-treated patients (66.95 +/- 16.78 vs. 27.15 +/- 17.92 pg/mL, P < 0.001) and in controls (71.7 +/- 16.2 vs. 53.2 +/- 18.4 pg/mL, P < 0.001) from T(0) to T(1). However, urinary PGE(2) at T(1) was significantly lower (P < 0.001) in the ibuprofen group compared to the control group. Acute renal failure occurred in three ibuprofen-treated patients (15%).
CONCLUSIONS : Ibuprofen markedly reduces (59.4%) urinary PGE(2) and may alter renal function in the newborn.
Publication: Eur. J. Clin. Pharmacol. 2009 Mar ;65(3)::223-30. :doi: 10.1007/s00228-008-0586-3.
Publication Date: 2009 Mar
Study Author(s): Antonucci, R;Cuzzolin, L;Arceri, A;Dessì, A;Fanos, V;
Institution: Department of Pediatrics and Clinical Medicine-Section of Neonatal Intensive Care Unit, University of Cagliari, Via Ospedale 119, 09124 Cagliari, Italy. [email protected]
Shortcut link to this study:
Publication Date: 2009 Mar
Study Author(s): Antonucci, R;Cuzzolin, L;Arceri, A;Dessì, A;Fanos, V;
Institution: Department of Pediatrics and Clinical Medicine-Section of Neonatal Intensive Care Unit, University of Cagliari, Via Ospedale 119, 09124 Cagliari, Italy. [email protected]
Shortcut link to this study:
PURPOSE : To investigate changes in urinary PGE(2) after ibuprofen treatment in preterm infants with patent ductus arteriosus (PDA).
METHODS : Twenty preterm infants with a hemodynamically significant PDA (gestational age, 28.6 +/- 2.3 weeks) and 20 controls (gestational age, 30.4 +/- 1.5 weeks) were prospectively enrolled at 48-72 h of life. After enrollment, the former underwent conventional ibuprofen-lysine treatment. At 48-72 h (T(0)) and 108-144 h of life (T(1)), urine samples were noninvasively collected in both groups to measure urinary PGE(2) concentrations (enzyme immunoassay method), and renal function was investigated.
RESULTS : Urinary PGE(2) decreased significantly both in ibuprofen-treated patients (66.95 +/- 16.78 vs. 27.15 +/- 17.92 pg/mL, P < 0.001) and in controls (71.7 +/- 16.2 vs. 53.2 +/- 18.4 pg/mL, P < 0.001) from T(0) to T(1). However, urinary PGE(2) at T(1) was significantly lower (P < 0.001) in the ibuprofen group compared to the control group. Acute renal failure occurred in three ibuprofen-treated patients (15%).
CONCLUSIONS : Ibuprofen markedly reduces (59.4%) urinary PGE(2) and may alter renal function in the newborn.
METHODS : Twenty preterm infants with a hemodynamically significant PDA (gestational age, 28.6 +/- 2.3 weeks) and 20 controls (gestational age, 30.4 +/- 1.5 weeks) were prospectively enrolled at 48-72 h of life. After enrollment, the former underwent conventional ibuprofen-lysine treatment. At 48-72 h (T(0)) and 108-144 h of life (T(1)), urine samples were noninvasively collected in both groups to measure urinary PGE(2) concentrations (enzyme immunoassay method), and renal function was investigated.
RESULTS : Urinary PGE(2) decreased significantly both in ibuprofen-treated patients (66.95 +/- 16.78 vs. 27.15 +/- 17.92 pg/mL, P < 0.001) and in controls (71.7 +/- 16.2 vs. 53.2 +/- 18.4 pg/mL, P < 0.001) from T(0) to T(1). However, urinary PGE(2) at T(1) was significantly lower (P < 0.001) in the ibuprofen group compared to the control group. Acute renal failure occurred in three ibuprofen-treated patients (15%).
CONCLUSIONS : Ibuprofen markedly reduces (59.4%) urinary PGE(2) and may alter renal function in the newborn.
PMID: 19048246
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