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char = t;code = 116
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char = .;code = 46
result sql = Circulating concentrations of monocyte chemoattractant protein-1 are associated with menopause status in Korean women.
Circulating concentrations of monocyte chemoattractant protein-1 are associated with menopause status in Korean women.
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char = e;code = 101
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result sql = BACKGROUND : Monocyte chemoattractant protein-1 (MCP-1) plays a role in adipose tissue inflammation and insulin resistance. Human circulating MCP-1 concentrations reportedly increase or remain unchanged according to obesity or insulin resistance in various ethnic populations; whether or not circulating MCP-1 concentrations increase after menopause has remained unclear.

METHODS : We investigated the relationship between circulating MCP-1 concentrations and obesity or insulin resistance, and the relationship between circulating MCP-1 and menopause status in premenopausal (n=111) and postmenopausal (n=64) Korean women.

RESULTS : Circulating MCP-1 concentrations were significantly higher in postmenopausal women than in obesity-matched premenopausal women; they did not differ between non-obese and obese subgroups of pre- and postmenopausal women. Circulating MCP-1 concentrations had a relationship with menopause status (rho=0.500, p=0.000), irrespective of obesity, but no relationship with obesity or insulin resistance. Circulating MCP-1 concentrations correlated with serum triglycerides (r=0.4, p=0.001) and also correlated with serum triglyceride concentrations, after adjusting for age and obesity, in postmenopausal women.

CONCLUSIONS : Circulating MCP-1 concentrations are associated with menopause status itself, irrespective of obesity; they do not correlate with obesity or insulin resistance in Korean women, most of whom are not severely obese.

Publication: Clin. Chim. Acta 2009 May ;403(1-2)::92-6. :doi: 10.1016/j.cca.2009.01.025.
Publication Date: 2009 May
Study Author(s): Park, Kang-Seo;Ahn, Kyu-Jeung;Kim, Byung-Joon;Kim, Hyun-Jin;Yoo, Seung Min;Kim, Ju-Young;Lee, Ki-Ho;Baik, Haing-Woon;Lee, Seong-Kyu;
Institution: Department of Internal Medicine, School of Medicine, Eulji University, Daejeon, Korea.
Shortcut link to this study:
BACKGROUND : Monocyte chemoattractant protein-1 (MCP-1) plays a role in adipose tissue inflammation and insulin resistance. Human circulating MCP-1 concentrations reportedly increase or remain unchanged according to obesity or insulin resistance in various ethnic populations; whether or not circulating MCP-1 concentrations increase after menopause has remained unclear.

METHODS : We investigated the relationship between circulating MCP-1 concentrations and obesity or insulin resistance, and the relationship between circulating MCP-1 and menopause status in premenopausal (n=111) and postmenopausal (n=64) Korean women.

RESULTS : Circulating MCP-1 concentrations were significantly higher in postmenopausal women than in obesity-matched premenopausal women; they did not differ between non-obese and obese subgroups of pre- and postmenopausal women. Circulating MCP-1 concentrations had a relationship with menopause status (rho=0.500, p=0.000), irrespective of obesity, but no relationship with obesity or insulin resistance. Circulating MCP-1 concentrations correlated with serum triglycerides (r=0.4, p=0.001) and also correlated with serum triglyceride concentrations, after adjusting for age and obesity, in postmenopausal women.

CONCLUSIONS : Circulating MCP-1 concentrations are associated with menopause status itself, irrespective of obesity; they do not correlate with obesity or insulin resistance in Korean women, most of whom are not severely obese.
PMID: 19361458

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