|
|
char = L;code = 76
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char = m;code = 109
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char = b;code = 98
char = a;code = 97
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result sql = Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism.
Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism.char = S;code = 83
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char = f;code = 102
char = e;code = 101
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char = b;code = 98
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char = 3;code = 51
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char = i;code = 105
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char = m;code = 109
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char = m;code = 109
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char = t;code = 116
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char = c;code = 99
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char = t;code = 116
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char = o;code = 111
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char = ;code = 32
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char = 8;code = 56
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char = ;code = 32
char = i;code = 105
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char = r;code = 114
char = e;code = 101
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char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = ;code = 32
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char = .;code = 46
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char = -;code = 45
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = 2;code = 50
char = -;code = 45
char = O;code = 79
char = H;code = 72
char = E;code = 69
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = 3;code = 51
char = 3;code = 51
char = .;code = 46
char = 3;code = 51
char = %;code = 37
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = 1;code = 49
char = 6;code = 54
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = -;code = 45
char = O;code = 79
char = H;code = 72
char = E;code = 69
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = 9;code = 57
char = .;code = 46
char = 2;code = 50
char = -;code = 45
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = E;code = 69
char = 3;code = 51
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = u;code = 117
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = M;code = 77
char = C;code = 67
char = F;code = 70
char = -;code = 45
char = 7;code = 55
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = i;code = 105
char = r;code = 114
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
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char = n;code = 110
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = E;code = 69
char = 2;code = 50
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = L;code = 76
char = B;code = 66
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = w;code = 119
char = n;code = 110
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char = e;code = 101
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char = u;code = 117
char = l;code = 108
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char = t;code = 116
char = e;code = 101
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char = E;code = 69
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char = o;code = 111
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
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char = n;code = 110
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char = e;code = 101
char = r;code = 114
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = 1;code = 49
char = 6;code = 54
char = a;code = 97
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = -;code = 45
char = O;code = 79
char = H;code = 72
char = E;code = 69
char = 1;code = 49
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = E;code = 69
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char = >;code = 62
result sql = Selective estrogen receptor modulators represent accepted therapy for estrogen receptor positive (ER+) breast cancer, exhibit adverse side effects, and reduce patient compliance. The use of phytoestrogen containing herbal medicines is limited because of efficacy and safety concerns. The ER+ MCF-7 model examined growth inhibitory effects of the medicinal herb Lycium barbarum (LB) and identified mechanistic leads for its efficacy. The MCF-7 cells maintained in 0.7% serum (17beta-estradiol, E2 < 1 nM) exhibited 11%-87% increased growth after treatment with 1nM to 20 nM E2. Growth promotion with 20 nM E2 exhibited 5.2-fold increased estrone (E1), 35.7% increased 2-hydroxyestrone (2-OHE1), 15.4% increased 16alpha-hydroxyestrone (16alpha-OHE1), and eightfold increased estriol (E3) formation. Treatment of E2 stimulated cells with LB exhibited a dose-dependent growth inhibition of 9.5%-42.8% at Day 3 and 33.9%-83.9% at Day 7. The 3-day inhibitory response to 1% LB (maximum cytostatic concentration) exhibited 84.8% increased E1, 3.6-fold increased 2-OHE1, 33.3% decreased 16alpha-OHE1, and 9.2-fold increased E3 formation. Thus, MCF-7 cells retain their mitogenic and metabolic response to E2 and LB downregulates E2-stimulated growth via the formation of antiproliferative 2-OHE1 and accelerated conversion of mitogenic 16alpha-OHE1 to antimitogenic E3.
char = y;code = 121
char = c;code = 99
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = b;code = 98
char = a;code = 97
char = r;code = 114
char = b;code = 98
char = a;code = 97
char = r;code = 114
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = v;code = 118
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = d;code = 100
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = .;code = 46
result sql = Lycium barbarum inhibits growth of estrogen receptor positive human breast cancer cells by favorably altering estradiol metabolism.
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char = d;code = 100
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char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = p;code = 112
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char = n;code = 110
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char = (;code = 40
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char = a;code = 97
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char = ;code = 32
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char = ;code = 32
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char = d;code = 100
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char = c;code = 99
char = e;code = 101
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char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = l;code = 108
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char = a;code = 97
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char = T;code = 84
char = h;code = 104
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char = s;code = 115
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char = t;code = 116
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char = e;code = 101
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char = c;code = 99
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char = t;code = 116
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char = n;code = 110
char = i;code = 105
char = n;code = 110
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char = h;code = 104
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char = r;code = 114
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char = a;code = 97
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = l;code = 108
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char = m;code = 109
char = i;code = 105
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char = d;code = 100
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char = e;code = 101
char = c;code = 99
char = a;code = 97
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char = s;code = 115
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
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char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = c;code = 99
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char = a;code = 97
char = f;code = 102
char = e;code = 101
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char = c;code = 99
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char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = n;code = 110
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = E;code = 69
char = R;code = 82
char = +;code = 43
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char = M;code = 77
char = C;code = 67
char = F;code = 70
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char = d;code = 100
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char = r;code = 114
char = o;code = 111
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char = n;code = 110
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char = i;code = 105
char = b;code = 98
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char = t;code = 116
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char = r;code = 114
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = o;code = 111
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char = ;code = 32
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char = h;code = 104
char = e;code = 101
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char = m;code = 109
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char = n;code = 110
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char = h;code = 104
char = e;code = 101
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char = b;code = 98
char = ;code = 32
char = L;code = 76
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char = c;code = 99
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char = u;code = 117
char = m;code = 109
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char = b;code = 98
char = a;code = 97
char = r;code = 114
char = b;code = 98
char = a;code = 97
char = r;code = 114
char = u;code = 117
char = m;code = 109
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char = (;code = 40
char = L;code = 76
char = B;code = 66
char = );code = 41
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = e;code = 101
char = d;code = 100
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char = m;code = 109
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char = c;code = 99
char = h;code = 104
char = a;code = 97
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char = i;code = 105
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = l;code = 108
char = e;code = 101
char = a;code = 97
char = d;code = 100
char = s;code = 115
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = c;code = 99
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = M;code = 77
char = C;code = 67
char = F;code = 70
char = -;code = 45
char = 7;code = 55
char = ;code = 32
char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = s;code = 115
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char = m;code = 109
char = a;code = 97
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char = n;code = 110
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char = a;code = 97
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = .;code = 46
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char = %;code = 37
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char = e;code = 101
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char = m;code = 109
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char = (;code = 40
char = 1;code = 49
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char = b;code = 98
char = e;code = 101
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char = t;code = 116
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char = i;code = 105
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char = E;code = 69
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char = <;code = 60
char = ;code = 32
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char = h;code = 104
char = i;code = 105
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char = d;code = 100
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char = 1;code = 49
char = 1;code = 49
char = %;code = 37
char = -;code = 45
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char = 7;code = 55
char = %;code = 37
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char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = e;code = 101
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char = g;code = 103
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char = t;code = 116
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char = a;code = 97
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char = t;code = 116
char = e;code = 101
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char = t;code = 116
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char = 2;code = 50
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char = ;code = 32
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char = t;code = 116
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char = ,;code = 44
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char = 1;code = 49
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char = ,;code = 44
char = ;code = 32
char = 1;code = 49
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char = h;code = 104
char = a;code = 97
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char = E;code = 69
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char = ,;code = 44
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char = a;code = 97
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char = i;code = 105
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char = e;code = 101
char = a;code = 97
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char = m;code = 109
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char = a;code = 97
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char = E;code = 69
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char = O;code = 79
char = H;code = 72
char = E;code = 69
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = 3;code = 51
char = 3;code = 51
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char = a;code = 97
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char = H;code = 72
char = E;code = 69
char = 1;code = 49
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char = ;code = 32
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result sql = Selective estrogen receptor modulators represent accepted therapy for estrogen receptor positive (ER+) breast cancer, exhibit adverse side effects, and reduce patient compliance. The use of phytoestrogen containing herbal medicines is limited because of efficacy and safety concerns. The ER+ MCF-7 model examined growth inhibitory effects of the medicinal herb Lycium barbarum (LB) and identified mechanistic leads for its efficacy. The MCF-7 cells maintained in 0.7% serum (17beta-estradiol, E2 < 1 nM) exhibited 11%-87% increased growth after treatment with 1nM to 20 nM E2. Growth promotion with 20 nM E2 exhibited 5.2-fold increased estrone (E1), 35.7% increased 2-hydroxyestrone (2-OHE1), 15.4% increased 16alpha-hydroxyestrone (16alpha-OHE1), and eightfold increased estriol (E3) formation. Treatment of E2 stimulated cells with LB exhibited a dose-dependent growth inhibition of 9.5%-42.8% at Day 3 and 33.9%-83.9% at Day 7. The 3-day inhibitory response to 1% LB (maximum cytostatic concentration) exhibited 84.8% increased E1, 3.6-fold increased 2-OHE1, 33.3% decreased 16alpha-OHE1, and 9.2-fold increased E3 formation. Thus, MCF-7 cells retain their mitogenic and metabolic response to E2 and LB downregulates E2-stimulated growth via the formation of antiproliferative 2-OHE1 and accelerated conversion of mitogenic 16alpha-OHE1 to antimitogenic E3.
Publication: Nutr Cancer 2009 ;61(3)::408-14. :doi: 10.1080/01635580802585952.
Publication Date: 2009
Study Author(s): Li, Go;Sepkovic, Daniel W;Bradlow, H Leon;Telang, Nitin T;Wong, George Y C;
Institution: Strang Cancer Prevention Center, New York, New York, USA.
Shortcut link to this study:
Publication Date: 2009
Study Author(s): Li, Go;Sepkovic, Daniel W;Bradlow, H Leon;Telang, Nitin T;Wong, George Y C;
Institution: Strang Cancer Prevention Center, New York, New York, USA.
Shortcut link to this study:
Selective estrogen receptor modulators represent accepted therapy for estrogen receptor positive (ER+) breast cancer, exhibit adverse side effects, and reduce patient compliance. The use of phytoestrogen containing herbal medicines is limited because of efficacy and safety concerns. The ER+ MCF-7 model examined growth inhibitory effects of the medicinal herb Lycium barbarum (LB) and identified mechanistic leads for its efficacy. The MCF-7 cells maintained in 0.7% serum (17beta-estradiol, E2 < 1 nM) exhibited 11%-87% increased growth after treatment with 1nM to 20 nM E2. Growth promotion with 20 nM E2 exhibited 5.2-fold increased estrone (E1), 35.7% increased 2-hydroxyestrone (2-OHE1), 15.4% increased 16alpha-hydroxyestrone (16alpha-OHE1), and eightfold increased estriol (E3) formation. Treatment of E2 stimulated cells with LB exhibited a dose-dependent growth inhibition of 9.5%-42.8% at Day 3 and 33.9%-83.9% at Day 7. The 3-day inhibitory response to 1% LB (maximum cytostatic concentration) exhibited 84.8% increased E1, 3.6-fold increased 2-OHE1, 33.3% decreased 16alpha-OHE1, and 9.2-fold increased E3 formation. Thus, MCF-7 cells retain their mitogenic and metabolic response to E2 and LB downregulates E2-stimulated growth via the formation of antiproliferative 2-OHE1 and accelerated conversion of mitogenic 16alpha-OHE1 to antimitogenic E3.
PMID: 19373615
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